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Vishnu Anand Cuddapah, MD, PhD

Instructor A of Neurology
Attending Physician, Children's Hospital of Philadelphia
Instructor of Neurology, University of Pennsylvania
Department: Neurology

Contact information
BS (Neuroscience)
Tulane University, 2006.
BA (Art History)
Tulane University, 2006.
PhD (Neurobiology)
University of Alabama at Birmingham, 2012.
MD (Medical Scientist Training Program)
University of Alabama at Birmingham, 2015.
Post-Graduate Training
Intern in Pediatrics, Children's Hospital of Philadelphia, 2015-2016.
Resident in Pediatrics, Children's Hospital of Philadelphia, 2016-2017.
Resident in Child Neurology, Children's Hospital of Philadelphia, 2017-2020.
Fellowship in Neurogenetics, Children's Hospital of Philadelphia, 2020-2021.
Post-Doctoral Research Fellowship, University of Pennsylvania, 2021-2023.
American Board of Psychiatry and Neurology (ABPN) with Special Qualifications in Child Neurology, 2020.
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Selected Publications

Parthasarathy S, Ruggiero SM, Gelot A, Soardi FC, Ribeiro BFR, Pires DEV, Ascher DB, Schmitt A, Rambaud C, Represa A, Xie HM, Lusk L, Wilmarth O, McDonnell PP, Juarez OA, Grace AN, Buratti J, Mignot C, Gras D, Nava C, Pierce SR, Keren B, Kennedy BC, Pena SDJ, Helbig I, Cuddapah VA.: A recurrent de novo splice site variant involving DNM1 exon 10a causes developmental and epileptic encephalopathy through a dominant-negative mechanism. Am J Hum Genet 109(12): 2253-2269, Dec 2022.

Zhu Z, Bolt E, Newmaster K, Osei-Bonsu W, Cohen S, Cuddapah VA, Gupta S, Paudel S, Samanta D, Dang LT, Carney PR, Naik S.: SCN1B Genetic Variants: A Review of the Spectrum of Clinical Phenotypes and a Report of Early Myoclonic Encephalopathy. Children (Basel) 9(10): 1507, Oct 2022.

Cuddapah VA, Goldberg EM.: REVing up the Brain: A Mechanism Driving Seizure Timing. Epilepsy Curr 22: 64-65, Oct 2021.

Cuddapah VA, Dubbs HA, Adang L, Kugler SL, McCormick EM, Zolkipli-Cunningham Z, Ortiz-González XR, McCormack S, Zackai E, Licht DJ, Falk MJ, Marsh ED.: Understanding the phenotypic spectrum of ASXL-related disease: Ten cases and a review of the literature. Am J Med Genet A 185(6): 1700-1711, Jun 2021.

Cuddapah VA, Zhang SL, Sehgal A: Regulation of the Blood-Brain Barrier by Circadian Rhythms and Sleep. Trends Neurosci 42(7): 500-510, Jul 2019.

Banka S, Sayer R, Breen C, Barton S, Pavaine J, Sheppard SE, Bedoukian E, Skraban C, Cuddapah VA, Clayton-Smith J.: Genotype-phenotype specificity in Menke-Hennekam syndrome caused by missense variants in exon 30 or 31 of CREBBP. Am J Med Genet A 179(6), Jun 2019.

Kahanovitch U, Cuddapah VA, Pacheco NL, Holt LM, Mulkey DK, Percy AK, Olsen ML.: MeCP2 Deficiency Leads to Loss of Glial Kir4.1. eNeuro 5: ENEURO, Feb 2018.

Nwaobi SE, Cuddapah VA, Patterson KC, Randolph AC, Olsen ML.: The role of glial-specific Kir4.1 in normal and pathological states of the CNS. Acta Neuropathol 132(1): 1-21, Jul 2016.

Cuddapah VA, Sinifunanya EN, Percy AK, Olsen ML.: MeCP2 in the regulation of neural activity: Rett syndrome pathophysiological perspectives. Degener Neurol Neuromuscul Dis 5: 103-116, Oct 2015.

Cuddapah VA, Thompson M, Blount J, Li R, Guleria S, Goyal M.: Hemispherectomy for Hemimegalencephaly Due to Tuberous Sclerosis and a Review of the Literature. Pediatr Neurol 53(5): 452-5, Nov 2015.

Campbell SL, Robel S, Cuddapah VA, Robert S, Buckingham SC, Kahle KT, Sontheimer H: GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia 63(1): 23-36, Jan 2015.

Cuddapah VA, Robel S, Watkins S, Sontheimer H.: A neurocentric perspective on glioma invasion. Nat Rev Neurosci 15(7): 455-65, Jul 2014.

Cuddapah VA, Pillai RB, Shekar KV, Lane JB, Motil KJ, Skinner SA, Tarquinio DC, Glaze DG, McGwin G, Kaufmann WE, Percy AK, Neul JL, Olsen ML.: Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in Rett syndrome. J Med Genet 51(3): 152-8, Mar 2014.

Cuddapah VA, Turner KL, Seifert S, Sontheimer H.: Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and ClC-3. J Neurosci 33: 1427-40, Jan 2013.

Cuddapah VA, Turner KL, Sontheimer H: Calcium entry via TRPC1 channels activates chloride currents in human glioma cells. Cell Calcium 53(3): 187-94, Mar 2013.

McFerrin MB, Turner KL, Cuddapah VA, Sontheimer H.: Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death. Am J Physiol Cell Physiol 303: C1070-8, Nov 2012.

Cuddapah VA, Habela CW, Watkins S, Moore LS, Barclay TT, Sontheimer H.: Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding. Am J Physiol Cell Physiol 302: C527-38, Feb 2012.

Haas BR, Cuddapah VA, Watkins S, Rohn KJ, Dy TE, Sontheimer H.: With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume. Am J Physiol Cell Physiol 301(5): 1150-60, Nov 2011.

Cuddapah VA, Sontheimer H.: Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration. Am J Physiol Cell Physiol 301(3): 541-9, Sept 2011.

Cuddapah VA, Sontheimer H.: Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. J Biol Chem 285: 11188-96, Apr 2010.

Corey DM, Cuddapah VA.: Delayed auditory feedback effects during reading and conversation tasks: gender differences in fluent adults. J Fluency Disord 33(4): 291-305, Dec 2008.

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Last updated: 09/19/2023
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