faculty photo

Dennis J. Dlugos, MD, MSCE

Professor of Neurology at the Children's Hospital of Philadelphia
Director, Pediatric Epilepsy Program, Division of Neurology, The Children's Hospital of Philadelphia
Associate Dean for UME Science and Discovery Curriculum, Perelman School of Medicine at the University of Pennsylvania
Department: Neurology

Contact information
Division of Neurology
The Children's Hospital of Philadelphia
34th and Civic Center Blvd
Colket Translational Research Building
10th floor, Room 10020
Philadelphia, PA 19104
Office: 215-590-1719
Fax: 215-590-2950
Education:
B.A. (Theology)
Loyola Marymount University, Los Angeles, CA, 1983.
M.D. (Medicine)
Columbia University College of Physicians & Surgeons, New York, NY, 1988.
M.S.C.E (Clinical Epidemiology)
Master’s of Science in Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
Post-Graduate Training
Intern in Pediatrics, National Naval Medical Center, Bethesda, MD, 1988-1989.
Resident in Pediatrics, Thomas Jefferson University & Alfred I. Dupont Institute, Philadelphia, PA & Wilmington, DE, 1993-1994.
Resident in Neurology/Child Neurology, University of Pennsylvania Medical Center & The Children’s Hospital of Philadelphia, Philadelphia , 1994-1997.
Fellow in Epilepsy and Clinical Neurophysiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 1997-1999.
Certifications
Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology, 1998.
Pediatrics (1998 - 2012), American Board of Pediatrics, 1998.
Clinical Neurophysiology (1999-2009), American Board of Psychiatry and Neurology, 1999.
Clinical Neurophysiology with Special Qualifications in Epilepsy Monitoring, American Board of Clinical Neurophysiology, 1999.
Epilepsy, American Board of Psychiatry and Neurology, 2013.
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Description of Research Expertise

Epilepsy Epidemiology
Epilepsy Genetics
Clinical Prediction Models

Description of Clinical Expertise

Pediatric Epilepsy
Epilepsy Genetics
Epilepsy Surgery
EEG
Clinical Neurophysiology

Selected Publications

Almoguera-Castillo BB, Robbins E, Abrams D, Vazquez L, Cederquist A, Dlugos D, Abou-Sleiman p, Hakonarson H: Drug-resistant epilepsy, classified by a phenotyping algorithm, associates with NTRK2. Acta Neurologica Scandinavica 140: 169-176, 2019.

Fitzgerald MP, Fiannacca M, Smith DM, Gertler TS, Gunning B, Syrbe S, Verbeek N, Stamberger H, Weckhuysen S, Ceulemans B, Schoonjans AS, Rossi M, Demarquay G, Lesca G, Olofsson K, Koolen DA, Hornemann F, Baulac S, Rubboli G, Minks KQ, Lee B, Helbig I, Dlugos D, Møller RS, Bearden D: Treatment Responsiveness in KCNT1-Related Epilepsy. Neurotherapeutics doi: 10.1007/s13311-019-00739-y 2019.

The Epilepsy Genetics Initiative (including Dlugos, DJ): The Epilepsy Genetics Initiative: Systematic reanalysis of diagnostic exomes increases yield. Epilepsia 60: 797-806, 2019.

Wheless JW, Dlugos D, Miller I, Oh DA, Parikh N, Phillips S, Renfroe JB, Roberts C, Saeed I, Sparagana SP, Cilio8 MR, on behalf of the INS011-14-029 Study Investigators: Pharmacokinetics and Tolerability of Multiple Doses of Pharmacuetical-Grade Synthetic Cannabidol Oral Solution in Pediatric Patients With Treatment-Resistant Seizure Disorders. CNS Drugs 33: 593-604, 2019.

The EPGP and Epi4K Consortia (including Dlugos DJ): Application of Rare Variant Transmission-Disequilibrium Tests to Epileptic Encephalopathy Trio Sequence Data. European Journal of Human Genetics 25: 894-9, 2018.

The Brainstem Consortium (including Dlugos D): Analysis of shared heritability in common disorders of the brain. Science 360: 6395, 2018.

Yuskaitis C, Ruzhnikov M, Howell K, Allen I, Kapur K, Dlugos D, Scheffer I, Poduri A, Sherr E : Infantile spasms of unknown cause: predictors of outcome and geneotype-phenotype correlation. Pediatric Neurology 87: 48-56, 2018.

Kim H, Kim SY, Lim BC, Hwang H, Chae JH, Choi J, Kim KJ, Dlugos DJ.: Spike persistence and normalization in benign epilepsy with centrotemporal spikes - Implications for management. Brain and Development 40: 693-8, 2018.

The International League Against Epilepsy Consortium on Complex Epilepsies (including Dlugos, DJ): Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nature Communications 10: 5269, 2018.

Devinsky O, Patel AD, Cross JH, Villanueva V, Wirrell EC, Privitera M, Greenwood SM, Roberts C, Checketts D, VanLandingham KE, Zuberi SM; GWPCARE3 Study Group (including Dlugos, DJ): Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome New England Journal of Medicine 378: 1888-97, 2018.

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Last updated: 01/28/2020
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