faculty photo

Dennis J. Dlugos, MD, MSCE

Professor of Neurology at the Children's Hospital of Philadelphia
Director, Pediatric Epilepsy Program, Division of Neurology, The Children's Hospital of Philadelphia
Associate Dean for UME Science and Discovery Curriculum, Perelman School of Medicine at the University of Pennsylvania
Department: Neurology

Contact information
Division of Neurology
Children's Hospital of Philadelphia
34th Street and Civic Center Blvd
The Hub for Clinical Collaboration
10th floor, Room 10537
Philadelphia, PA 19104
Office: 215-590-1719
Education:
B.A. (Theology)
Loyola Marymount University, Los Angeles, CA, 1983.
M.D. (Medicine)
Columbia University College of Physicians & Surgeons, New York, NY, 1988.
M.S.C.E (Clinical Epidemiology)
Master’s of Science in Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
Post-Graduate Training
Intern in Pediatrics, National Naval Medical Center, Bethesda, MD, 1988-1989.
Resident in Pediatrics, Thomas Jefferson University & Alfred I. Dupont Institute, Philadelphia, PA & Wilmington, DE, 1993-1994.
Resident in Neurology/Child Neurology, University of Pennsylvania Medical Center & The Children’s Hospital of Philadelphia, Philadelphia , 1994-1997.
Fellow in Epilepsy and Clinical Neurophysiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 1997-1999.
Certifications
Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology, 1998.
Pediatrics (1998 - 2012), American Board of Pediatrics, 1998.
Clinical Neurophysiology (1999-2009), American Board of Psychiatry and Neurology, 1999.
Clinical Neurophysiology with Special Qualifications in Epilepsy Monitoring, American Board of Clinical Neurophysiology, 1999.
Epilepsy, American Board of Psychiatry and Neurology, 2013.
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Description of Research Expertise

Epilepsy Epidemiology
Epilepsy Genetics
Clinical Prediction Models

Description of Clinical Expertise

Pediatric Epilepsy
Epilepsy Genetics
Epilepsy Surgery
EEG
Clinical Neurophysiology

Selected Publications

Bozorg A, Beller C, Jensen L, Arzimanoglou A, Chiron C, Dlugos D, Gaitanis J, Wheless J, McClung C: Pitfalls of Using Video-EEG for a Trial Endpoint in Children Aged <4 Years with Focal Seizures. Annals of Clinical and Translational Neurology Page: 10.1002/acn3.51999, 2024.

Ellis CA, Tu D, Oliver KL, Mefford HC, Hauser WA, Buchhalter J, Epstein MP, Cao Q, EPGP Consortium (including Dlugos DJ), Epi4K Consortium (including Dlugos DJ), Berkovic SF, Ottman R: Familial aggregation of seizure outcomes in four familial epilepsy cohorts. Epilepsia Page: 10.1111/epi.18004, 2024.

Jandhyala N, Ferrer Socorro M, Greenwood H, Pellinen J, Dlugos D, Park K, Thio L, French J: Unrecognized Focal Non-Motor Seizures in Adolescents Presenting to Emergency Departments. Neurology 102: e209389, 2024.

Perry MS, Scheffer IE, Sullivan J, Brunklaus A, Boronat S, Wheless J, Laux L, Patel AD, Roberts CM, Dlugos D, Holder D, Knupp KG, Lallas1 M, Phillips S, Segal E, Smeyers P, Lal1 D, Wirrell E, Zuberi S, Brünger T, Wojnaroski M, Maru B, O’Donnell P, Morton M, James E, Vila C, Huang N, Gofshteyn JS, Rico S: Severe Communication Delays Are Independent of Seizure Burden and Persist Despite Contemporary Treatments in SCN1A+ Dravet Syndrome: Insights from the ENVISION Natural History Study. Epilepsia 65: 322-337, 2024.

Molisani SE, Parikh D, DiGiovine M, Dlugos D, Fitzgerald MP, Fried L, Helbig I, Kessler SK, McDonnell PP, Melamed S, Prelack MS, Sharif U, Tefft S, Tencer J, Witzman S, Shaw K, Abend NS: A quality improvement initiative to improve folic acid supplementation counseling for adolescent females with epilepsy. Epilepsia Page: 10.1111/epi.17723, July 2023.

Fox J, Barnard S, Agashe SH, Holmes M, Gidal B, Klein P, Abou-Khalil BW, French J, and the Human Epilepsy Project Investigators (including Dlugos D): Patterns of antiseizure medication utilization in the Human Epilepsy Project. Epilepsia 64: 3196-3204, 2023.

Andres M. Kanner, Anita S Saporta, Dong H Kim, John J Barry, Hamada Altalib, Hope Omotola, Nathalie Jette, Terence J O'Brien, Siddhartha Nadkarni, Melodie Winawer, Michael Sperling, Jaqueline A French, Bassel Abou-Khalil, Brian Alldredge, Martina Bebin, Gregory D Cascino, Andrew J Cole, Mark Cook, Kamil Detyniecki, Orrin Devinsky, Dennis Dlugos, Edward Faught, David Ficker, Madeline Fields, Barry Gidal, Michael Gelfand, Simon Glynn, Jonathan J Halford, Sheryl Haut, Manu Hegde, Manisha Holmes, Reetta Kalviainen, Joon Kang, Pavel Klein, Robert Knowlton, Kaarkuzhali Krishnamurthy, Ruben Kuzniecky, Patrick Kwan, Daniel Lowenstein, Lara Marcuse, Kimford J Meador, Scott Mintzer, Heath Pardoe, Kristen Park, Patricia Penovich, Rani K Singh, Ernest Somerville, Charles A Szabo, Jerzy Szaflarski, Liu Lin Thio, Eugen Trinka, and Jorge Burneo: Mood and Anxiety Disorders and Suicidality in Patients with Newly Diagnosed Focal Epilepsy: An Analysis of a Complex Comorbidity. Neurology 100: e1123-e1134, 2023.

Buchhalter J, Neuray C, Cheng J, D’Cruz O, Datta A, Dlugos D, French J, Haubenberger D, Hulihan J, Klein P, Komorowski R, Kramer L, Lothe A, Nabbout R, Perucca E, Van der Ark P: EEG parameters as endpoints in epilepsy clinical trials - An expert panel opinion paper. Epilepsy Research 187: 107028, Nov 2022.

Sperling MR, Wheless J, Hogan RE, Dlugos D, Cascino G, Liow K, Rabinowicz A, Carrazana E: Use of Second Doses of Diazepam Nasal Spray Across 24 Hours After the Initial Dose for Out-of-Hospital Seizure Clusters: Results From a Phase 3, Open-Label, Repeat-Dose Safety Study. Epilepsia 63: 836-843, 2022.

Koko M, Motelow JE, Stanley KE, Bobbili DR, Dhindsa RS, May P, Canadian Epilepsy Network, Epi4K Consortium, Epilepsy Phenome/Genome Project (including Dlugos D), EpiPGX Consortium, EuroEPINOMICS-CoGIE Consortium: Association of ultra-rare coding variants with genetic generalized epilepsy: a case control whole exome sequencing study Epilepsia 63: 723-735, 2022.

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Last updated: 07/14/2024
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