faculty photo

Dennis J. Dlugos, MD, MSCE

Professor of Neurology at the Children's Hospital of Philadelphia
Course Director, Brain and Behavior, Module 2, Perelman School of Medicine at the University of Pennsylvania
Director, Pediatric Regional Epilepsy Program, Division of Neurology, The Children's Hospital of Philadelphia
Director, Module 2, Perelman School of Medicine at the University of Pennsylvania
Department: Neurology

Contact information
Division of Neurology
The Children's Hospital of Philadelphia
34th and Civic Center Blvd
Colket Translational Research Building
10th floor, Room 10020
Philadelphia, PA 19104
Office: 215-590-1719
Fax: 215-590-2950
B.A. (Theology)
Loyola Marymount University, Los Angeles, CA, 1983.
M.D. (Medicine)
Columbia University College of Physicians & Surgeons, New York, NY, 1988.
M.S.C.E (Clinical Epidemiology)
Master’s of Science in Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
Post-Graduate Training
Intern in Pediatrics, National Naval Medical Center, Bethesda, MD, 1988-1989.
Resident in Pediatrics, Thomas Jefferson University & Alfred I. Dupont Institute, Philadelphia, PA & Wilmington, DE, 1993-1994.
Resident in Neurology/Child Neurology, University of Pennsylvania Medical Center & The Children’s Hospital of Philadelphia, Philadelphia , 1994-1997.
Fellow in Epilepsy and Clinical Neurophysiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 1997-1999.
Pediatrics (1998 - 2012), American Board of Pediatrics, 1998.
Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology, 1998.
Clinical Neurophysiology (1999-2009), American Board of Psychiatry and Neurology, 1999.
Clinical Neurophysiology with Special Qualifications in Epilepsy Monitoring, American Board of Clinical Neurophysiology, 1999.
Epilepsy, American Board of Psychiatry and Neurology, 2013.
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Description of Research Expertise

Epilepsy Epidemiology
Epilepsy Genetics
Clinical Prediction Models

Description of Clinical Expertise

Pediatric Epilepsy
Epilepsy Genetics
Epilepsy Surgery
Clinical Neurophysiology

Selected Publications

The EPGP and Epi4K Consortia (including Dlugos DJ): Application of Rare Variant Transmission-Disequilibrium Tests to Epileptic Encephalopathy Trio Sequence Data. European Journal of Human Genetics 25: 894-9, 2018.

Devinsky O, Patel AD, Cross JH, Villanueva V, Wirrell EC, Privitera M, Greenwood SM, Roberts C, Checketts D, VanLandingham KE, Zuberi SM; GWPCARE3 Study Group (including Dlugos, DJ): Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome New England Journal of Medicine 378: 1888-97, 2018.

Kim H, Kim SY, Lim BC, Hwang H, Chae JH, Choi J, Kim KJ, Dlugos DJ.: Spike persistence and normalization in benign epilepsy with centrotemporal spikes - Implications for management. Brain and Development 40: 693-8, 2018.

The Epi4K Consortium (including Dlugos D): De novo variants in the alternative exon 5 of SCN8A cause epileptic encephalopathy. Genetics in Medicine 20: 275-81, 2018.

Curatolo P, Franz DN, Lawson JA, Yapici Z, Ikeda H, Polster T, Nabbout R, de Vries PJ, Dlugos DJ, Fan J, Ridolfi A, Pelov D, Voi M, French JA: Adjunctive everolimus for children and adolescents with treatment-refractory seizures associated with tuberous sclerosis complex: post-hoc analysis of the phase 3 EXIST-3 trial. Lancet Child and Adolescent Health 2: 495-504, 2018.

Glauser TA, Holland K, O’Brien V, Keddache M, Clark PO, Cnaan A, Dlugos D, Hirtz DG, Shinnar S, Gregory G, for the Childhood Absence Epilepsy Study Group: Pharmacogenetics of Antiepileptic Drug Efficacy in Childhood Absence Epilepsy. Annals of Neurology 81: 444-53, 2017.

Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S, and the CBD Dravet Syndrome Study Group (including Dlugos DJ): Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome New England Journal of Medicine 376: 2011-20, 2017.

Sarah von Spiczak, Katherine L Helbig, Deepali N Shinde, Robert Huether, Manuela Pendziwiat, Charles M Lourenco, Mark E Nunes, Dean P Sarco, Richard A Kaplan, Dennis J Dlugos, Heidi Kirsch, Anne Slavotinek, Maria R Cilio, Mackenzie C Cervenka, Julie S Cohen, Rebecca McClellan, Ali Fatemi, Amy Yuen, Yoshimi Sogawa, Rebecca Littlejohn, Scott D McLean, Laura Hernandez-Hernandez, Bridget Maher, Rikke S Møller, Elizabeth Palmer, John A Lawson, Colleen A Campbell, Charuta N Joshi, Diana L Kolbe, Georgie Hollingsworth, Bernd A Neubauer, Hiltrud Muhle, Ulrich Stephani, Ingrid E Scheffer, Sérgio D J Pena, Sanjay M Sisodiya, and Ingo Helbig: DNM1 encephalopathy: a new disease of vesicle fission. Neurology 89: 385-94, 2017.

Kessler SK, Shinnar S, Cnaan A, Dlugos D, Conry J, Hirtz DG, Mizrahi EM, Moshé SL, Clark P, Glauser TA, for the Childhood Absence Epilepsy Study Group : Pretreatment Seizure Semiology in Childhood Absence Epilepsy Neurology 89: 673-9, 2017.

The Epi4K Consortium (including Dlugos DJ): Phenotypic analysis of 303 multiplex families with common epilepsies. Brain 140: 2144-56, 2017.

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Last updated: 09/18/2018
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