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Dennis J. Dlugos, MD, MSCE

Professor of Neurology at the Children's Hospital of Philadelphia
Director, Pediatric Epilepsy Program, Division of Neurology, The Children's Hospital of Philadelphia
Associate Dean for UME Science and Discovery Curriculum, Perelman School of Medicine at the University of Pennsylvania
Department: Neurology

Contact information
Division of Neurology
Children's Hospital of Philadelphia
34th and Civic Center Blvd
Colket Translational Research Building
1st floor, Room 1200.14
Philadelphia, PA 19104
Office: 215-590-1719
Fax: 215-590-2950
B.A. (Theology)
Loyola Marymount University, Los Angeles, CA, 1983.
M.D. (Medicine)
Columbia University College of Physicians & Surgeons, New York, NY, 1988.
M.S.C.E (Clinical Epidemiology)
Master’s of Science in Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
Post-Graduate Training
Intern in Pediatrics, National Naval Medical Center, Bethesda, MD, 1988-1989.
Resident in Pediatrics, Thomas Jefferson University & Alfred I. Dupont Institute, Philadelphia, PA & Wilmington, DE, 1993-1994.
Resident in Neurology/Child Neurology, University of Pennsylvania Medical Center & The Children’s Hospital of Philadelphia, Philadelphia , 1994-1997.
Fellow in Epilepsy and Clinical Neurophysiology, The Children’s Hospital of Philadelphia, Philadelphia, PA, 1997-1999.
Pediatrics (1998 - 2012), American Board of Pediatrics, 1998.
Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology, 1998.
Clinical Neurophysiology with Special Qualifications in Epilepsy Monitoring, American Board of Clinical Neurophysiology, 1999.
Clinical Neurophysiology (1999-2009), American Board of Psychiatry and Neurology, 1999.
Epilepsy, American Board of Psychiatry and Neurology, 2013.
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Description of Research Expertise

Epilepsy Epidemiology
Epilepsy Genetics
Clinical Prediction Models

Description of Clinical Expertise

Pediatric Epilepsy
Epilepsy Genetics
Epilepsy Surgery
Clinical Neurophysiology

Selected Publications

Bozorg A, Beller C, Jensen L, Arzimanoglou A, Chiron C, Dlugos D, Gaitanis J, Wheless J, McClung C: Pitfalls of Using Video-EEG for a Trial Endpoint in Children Aged <4 Years with Focal Seizures. Annals of Clinical and Translational Neurology Page: 10.1002/acn3.51999, 2024.

Molisani SE, Parikh D, DiGiovine M, Dlugos D, Fitzgerald MP, Fried L, Helbig I, Kessler SK, McDonnell PP, Melamed S, Prelack MS, Sharif U, Tefft S, Tencer J, Witzman S, Shaw K, Abend NS: A quality improvement initiative to improve folic acid supplementation counseling for adolescent females with epilepsy. Epilepsia Page: 10.1111/epi.17723, July 2023.

Buchhalter J, Neuray C, Cheng J, D’Cruz O, Datta A, Dlugos D, French J, Haubenberger D, Hulihan J, Klein P, Komorowski R, Kramer L, Lothe A, Nabbout R, Perucca E, Van der Ark P: EEG parameters as endpoints in epilepsy clinical trials - An expert panel opinion paper. Epilepsy Research 187: 107028, Nov 2022.

Sperling MR, Wheless J, Hogan RE, Dlugos D, Cascino G, Liow K, Rabinowicz A, Carrazana E: Use of Second Doses of Diazepam Nasal Spray Across 24 Hours After the Initial Dose for Out-of-Hospital Seizure Clusters: Results From a Phase 3, Open-Label, Repeat-Dose Safety Study. Epilepsia 63: 836-843, 2022.

Tarquinio D, Dlugos D, Wheless JW, Desai J, Carrazana E, Rabinowicz AL: Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study. Pediatric Neurology 132: 50-55, 2022.

Bank AM, Kuzniecky R, Knowlton RC, Cascino GD, Jackson G, Pardoe HR; Human Epilepsy Project Investigators (including Dlugos DJ): Structural Neuroimaging in Adults and Adolescents With Newly Diagnosed Focal Epilepsy: The Human Epilepsy Project. Neurology 99: e2181-7, 2022.

Koko M, Motelow JE, Stanley KE, Bobbili DR, Dhindsa RS, May P, Canadian Epilepsy Network, Epi4K Consortium, Epilepsy Phenome/Genome Project (including Dlugos D), EpiPGX Consortium, EuroEPINOMICS-CoGIE Consortium: Association of ultra-rare coding variants with genetic generalized epilepsy: a case control whole exome sequencing study Epilepsia 63: 723-735, 2022.

Hahn CD, Jiang Y, Villanueva V, Zolnowska M, Arkilo5 D, Hsiao S, Asgharnejad M, Dlugos D: A phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in pediatric patients with Dravet syndrome or Lennox–Gastaut syndrome (ELEKTRA). Epilepsia 63: 2671-2683, 2022.

Knupp KG, Coryell J, Singh RK, Gaillard W, Shellhaas R, Koh S, Mitchell WG, Harini C, Millichap JJ, May A, Dlugos D, Nickels K, Mytinger JR, Keator C, Yozawitz E, Singhal N, Lockrow J, Thomas JF, Juarez-Colunga E: Comparison of cosyntropin, vigabatrin and combination therapy in new onset infantile spasms in a prospective randomized trial. Journal of Child Neurology 37: 186-193, 2022.

Millichap JJ, Harden CL, Dlugos DJ, French JA, Butterfield NH, Grayson C, Aycardi E, Pimstone SN: Capturing seizures in clinical trials of anti-seizure medications for KCNQ2 DEE. Epilepsia Open 6: 38-44, 2021.

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Last updated: 02/23/2024
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