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Joseph Vithayathil, MD PhD
3eInstructor A of Neurology
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Instructor A of Neurology, University of Pennsylvania School of Medicine
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Department: Neurology
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Contact information
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3500 Civic Center Blvd
Philadelphia, PA 19104
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Philadelphia, PA 19104
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Office: 215-590-1719
32 Fax: 215-590-1771
32 Lab: 215-906-4152
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32 Fax: 215-590-1771
32 Lab: 215-906-4152
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Publications
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Links
d1 Search PubMed for articles
86 Children's Hospital of Philadelphia profile
cd Linked-in Profile
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d1 Search PubMed for articles
86 Children's Hospital of Philadelphia profile
cd Linked-in Profile
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Education:
21 9 B.A. 22 (Biology and Economics) c
3b Washington University in St. Louis, 2007.
21 8 PhD 1a (Neurosciences) c
38 Case Western Reserve University, 2015.
21 7 MD 1e (Medical Doctorate) c
38 Case Western Reserve University, 2017.
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21 9 B.A. 22 (Biology and Economics) c
3b Washington University in St. Louis, 2007.
21 8 PhD 1a (Neurosciences) c
38 Case Western Reserve University, 2015.
21 7 MD 1e (Medical Doctorate) c
38 Case Western Reserve University, 2017.
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Post-Graduate Training
24 5c Child Neurology Residency, Children's Hospital of Philadelphia, 2017-2022.
24 52 Research Fellow, Children's Hospital of Philadelphia, 2022-2023.
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24 5c Child Neurology Residency, Children's Hospital of Philadelphia, 2017-2022.
24 52 Research Fellow, Children's Hospital of Philadelphia, 2022-2023.
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Certifications
28 43 American Board of Psychiatry and Neurology, 2022.
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Permanent link28 43 American Board of Psychiatry and Neurology, 2022.
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271 He is actively pursuing basic science research projects studying the role of brain iron dysregulation and oxidative stress in perinatal hypoxic ischemic brain injury. In addition, he is interested in genetic pediatric neurodegenerative disorders that exhibit iron dysregulation in the brain to further understand how brain iron metabolism alterations contribute to cell death. He hopes to unravel some of the pathways that regulate the relationship between intracellular iron accumulation and oxidative stress as a way to identify novel therapeutic targets that can offer neuroprotection and prevent neurodegeneration.
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Description of Research Expertise
163 Dr. Joseph Vithayathil is a board-certified pediatric neurologist with the Division of Neurology at the Children’s Hospital of Philadelphia. His clinical interests are related to patients with movement disorders or disabilities due to perinatal hypoxic ischemic brain injury and neurogenetic disorders that affect brain iron metabolism.8
271 He is actively pursuing basic science research projects studying the role of brain iron dysregulation and oxidative stress in perinatal hypoxic ischemic brain injury. In addition, he is interested in genetic pediatric neurodegenerative disorders that exhibit iron dysregulation in the brain to further understand how brain iron metabolism alterations contribute to cell death. He hopes to unravel some of the pathways that regulate the relationship between intracellular iron accumulation and oxidative stress as a way to identify novel therapeutic targets that can offer neuroprotection and prevent neurodegeneration.
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19d Emma Kotes, Francesco Gavazzi, Sarah Woidill, Anjana Sevagamoorthy, Eric Yang, Vanessa Smith, Holly Dubbs, Samuel R Pierce, Kristy Pucci, Joseph Vithayathil, Nivedita Thakur, Laura A Adang: Determination of Health Concepts in Beta-propeller Protein-associated Neurodegeneration (BPAN). Journal of Child Neurology 40(1): 15-25, January 2025.
75 Joseph Vithayathil, Akash Virupakshaiah, Geraldine Liu, Sanjeev K Swami, 35 Robert A Avery, Grant T Liu, and Jennifer L McGuire b9 : Lyme Disease and Papilledema: A Retrospective Study on Clinical Characteristics and Outcomes. Journal of Child Neurology 39(9-10): 334-342, August 2024.
158 Xing B, Barbour AJ, Vithayathil J, Li X, Dutko S, Fawcett-Patel J, Lancaster E, Talos DM, Jensen FE.: Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures. Journal of Clinical Investigation 134: e175167, Jan 2024.
12a Vithayathil J, Freeman C, Jacobwitz M, Schwartz ES, Agarwal S.: Prolonged neurologic deficits with brain MRI changes following ECT in an adolescent with a CACNA1a-related disorder; a case report. BMC Neurol 22: 466, Dec 2022.
187 Gavazzi F, Pierce SR, Vithayathil J, Cunningham K, Anderson K, McCann J, Moll A, Muirhead K, Sherbini O, Prange E, Dubbs H, Tochen L, Fraser J, Helbig I, Lewin N, Thakur N, Adang LA.: Psychometric outcome measures in beta-propeller protein-associated neurodegeneration (BPAN). Mol Genet Metab 137: 26-32, Sep-Oct 2022.
d5 Vithayathil J, Adang L, Alves CAPF.: Widening the MRI Findings of PLA2G6-Associated Neurodegeneration. Neuropediatrics 6: 509-510, Dec 2021.
215 Fitzgerald MP, Kaufman MC, Massey SL, Fridinger S, Prelack M, Ellis C, Ortiz-Gonzalez X, Fried LE, DiGiovine MP; CHOP Pediatric Epilepsy Program Collaborative; Melamed S, Malcolm M, Banwell B, Stephenson D, Witzman SM, Gonzalez A, Dlugos D, Kessler SK, Goldberg EM, Abend NS, Helbig I. : Assessing seizure burden in pediatric epilepsy using an electronic medical record-based tool through a common data element approach. Epilepsia 62(7): 1617-1628, July 2021.
fc Vithayathil J, Pucilowska J, Landreth GE.: Chapter 3 - ERK/MAPK signaling and autism spectrum disorders. Progress in Brain Research. Anantha Shekhar (eds.). 241: 63-112, Nov 2018.
171 Pucilowska J, Vithayathil J, Pagani M, Kelly C, Karlo JC, Robol C, Morella I, Gozzi A, Brambilla R, Landreth GE.: Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice. J Neurosci 38: 6640-6652, Jul 2018.
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Selected Publications
158 Joseph Vithayathil, Anjali Shankar, Ginger L Milne, Frances E Jensen, Delia M Talos, Joshua L Dunaief: Temporal and cell-specific changes to cellular iron sequestration and lipid peroxidation in a murine model of neonatal hypoxic-ischemic brain injury. BioRxiv July 2025.19d Emma Kotes, Francesco Gavazzi, Sarah Woidill, Anjana Sevagamoorthy, Eric Yang, Vanessa Smith, Holly Dubbs, Samuel R Pierce, Kristy Pucci, Joseph Vithayathil, Nivedita Thakur, Laura A Adang: Determination of Health Concepts in Beta-propeller Protein-associated Neurodegeneration (BPAN). Journal of Child Neurology 40(1): 15-25, January 2025.
75 Joseph Vithayathil, Akash Virupakshaiah, Geraldine Liu, Sanjeev K Swami, 35 Robert A Avery, Grant T Liu, and Jennifer L McGuire b9 : Lyme Disease and Papilledema: A Retrospective Study on Clinical Characteristics and Outcomes. Journal of Child Neurology 39(9-10): 334-342, August 2024.
158 Xing B, Barbour AJ, Vithayathil J, Li X, Dutko S, Fawcett-Patel J, Lancaster E, Talos DM, Jensen FE.: Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures. Journal of Clinical Investigation 134: e175167, Jan 2024.
12a Vithayathil J, Freeman C, Jacobwitz M, Schwartz ES, Agarwal S.: Prolonged neurologic deficits with brain MRI changes following ECT in an adolescent with a CACNA1a-related disorder; a case report. BMC Neurol 22: 466, Dec 2022.
187 Gavazzi F, Pierce SR, Vithayathil J, Cunningham K, Anderson K, McCann J, Moll A, Muirhead K, Sherbini O, Prange E, Dubbs H, Tochen L, Fraser J, Helbig I, Lewin N, Thakur N, Adang LA.: Psychometric outcome measures in beta-propeller protein-associated neurodegeneration (BPAN). Mol Genet Metab 137: 26-32, Sep-Oct 2022.
d5 Vithayathil J, Adang L, Alves CAPF.: Widening the MRI Findings of PLA2G6-Associated Neurodegeneration. Neuropediatrics 6: 509-510, Dec 2021.
215 Fitzgerald MP, Kaufman MC, Massey SL, Fridinger S, Prelack M, Ellis C, Ortiz-Gonzalez X, Fried LE, DiGiovine MP; CHOP Pediatric Epilepsy Program Collaborative; Melamed S, Malcolm M, Banwell B, Stephenson D, Witzman SM, Gonzalez A, Dlugos D, Kessler SK, Goldberg EM, Abend NS, Helbig I. : Assessing seizure burden in pediatric epilepsy using an electronic medical record-based tool through a common data element approach. Epilepsia 62(7): 1617-1628, July 2021.
fc Vithayathil J, Pucilowska J, Landreth GE.: Chapter 3 - ERK/MAPK signaling and autism spectrum disorders. Progress in Brain Research. Anantha Shekhar (eds.). 241: 63-112, Nov 2018.
171 Pucilowska J, Vithayathil J, Pagani M, Kelly C, Karlo JC, Robol C, Morella I, Gozzi A, Brambilla R, Landreth GE.: Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice. J Neurosci 38: 6640-6652, Jul 2018.
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