Daniel T Ohm, PhD
Department: Neurology
Contact information
415 Curie Blvd.
Clinical Research Building, Rm 270
Philadelphia, PA 19104
Clinical Research Building, Rm 270
Philadelphia, PA 19104
Office: 6317071953
Publications
Education:
BS (Biology, Psychology)
Syracuse University, 2008.
PhD (Neuroscience)
Northwestern University, 2019.
BS (Biology, Psychology)
Syracuse University, 2008.
PhD (Neuroscience)
Northwestern University, 2019.
Post-Graduate Training
Postdoctoral Fellow in Neurology, University of Pennsylvania Perelman School of Medicine Department of Neurology, 2019-2023.
Permanent linkPostdoctoral Fellow in Neurology, University of Pennsylvania Perelman School of Medicine Department of Neurology, 2019-2023.
Description of Research Expertise
I have expertise in human neuroanatomy, cellular and systems neuroscience, and neurodegenerative proteinopathies including Alzheimer's disease and frontotemporal lobar degeneration. I investigate patterns of pathology and neurodegeneration in large-scale neuroanatomical studies of postmortem human tissue by using a combination of novel methods including digital histopathology, computer vision, machine learning, and bioinformatic analyses. I have strong experience performing translational research with multi-disciplinary approaches designed to determine the relationships between pathologic inclusions, neurodegeneration, neuroinflammation, structural MRI, and clinical impairments characteristic of neurodegenerative disorders including behavioral variant frontotemporal dementia and primary progressive aphasia. My long-term career goal and translational research program is to support the discovery of emerging biomarkers to improve diagnostics and inform therapeutic studies dedicated to developing neuroprotective treatments in neurodegenerative disorders.Selected Publications
Denning AE, Ittyerah R, Levorse LM, Sadeghpour N, Athalye C, Chung E, Ravikumar S, Dong M, Duong MT, Li Y, Ilesanmi A, Sreepada LP, Sabatini P, Lowe M, Bahena A, Zablah J, Spencer BE, Watanabe R, Kim B, Sørensen MH, Khandelwal P, Brown C, Hrybouski S, Xie SX, de Flores R, Robinson JL, Schuck T, Ohm DT, Arezoumandan S, Porta S, Detre JA, Insausti R, Wisse LEM, Das SR, Irwin DJ, Lee EB, Wolk DA, Yushkevich PA. : Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer's disease continuum. Acta Neuropathol 148(1): 37, Sep 2024.Ohm DT, Xie SX, Capp N, Arezoumandan S, Cousins KAQ, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, McMillan CT, Irwin DJ.: Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia. Brain July 2024.
Arezoumandan S, Cousins KAQ, Ohm DT, Lowe M, Chen M, Gee J, Phillips JS, McMillan CT, Luk KC, Deik A, Spindler MA, Tropea TF, Weintraub D, Wolk DA, Grossman M, Lee V, Chen-Plotkin AS, Lee EB, Irwin DJ.: Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Ann Clin Transl Neurol 11(3): 673-685, Mar 2024.
Ohm DT, Rhodes E, Bahena A, Capp N, Lowe M, Sabatini P, Trotman W, Olm CA, Phillips J, Prabhakaran K, Rascovsky K, Massimo L, McMillan C, Gee J, Tisdall MD, Yushkevich PA, Lee EB, Grossman M, Irwin DJ.: Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient. Front Neurol 14: 1245886, Oct 2023.
Giannini LA, Mol MO, Rajicic A, van Buuren R, Sarkar L, Arezoumandan S, Ohm DT, Irwin DJ, Rozemuller AJ; Netherlands Brain Bank; van Swieten JC, Seelaar H.: Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta Neuropathol Commun 11: 126, Aug 2023.
Sadaghiani S, Trotman W, Lim SA, Chung E, Ittyerah R, Ravikumar S, Khandelwal P, Prabhakaran K, Lavery ML, Ohm DT, Gabrielyan M, Das SR, Schuck T, Capp N, Peterson CS, Migdal E, Artacho-Pérula E, Jiménez MDMA, Rabal MDPM, Sánchez SC, Prieto CR, Parada MC, Insausti R, Robinson JL, McMillan C, Grossman M, Lee EB, Detre JA, Xie SX, Trojanowski JQ, Tisdall MD, Wisse LEM, Irwin DJ, Wolk DA, Yushkevich PA.: Associations of phosphorylated tau pathology with whole-hemisphere ex vivo morphometry in 7 tesla MRI. Alzheimers Dement 19(6): 2355-2364, Jun 2023.
Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ; Netherlands Brain Bank.: Correction to: Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta Neuropathol 145(5): 711, May 2023.
Giannini LAA, Ohm DT, Rozemuller AJM, Dratch L, Suh E, van Deerlin VM, Trojanowski JQ, Lee EB, van Swieten JC, Grossman M, Seelaar H, Irwin DJ; Netherlands Brain Bank.: Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration. Acta Neuropathol 144(6): 1065-1084, Dec 2022.
Arezoumandan S, Xie SX, Cousins KAQ, Mechanic-Hamilton DJ, Peterson CS, Huang CY, Ohm DT, Ittyerah R, McMillan CT, Wolk DA, Yushkevich P, Trojanowski JQ, Lee EB, Grossman M, Phillips JS, Irwin DJ.: Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta Neuropathol 144(6): 1103-1116, Dec 2022.
Cousins KAQ, Arezoumandan S, Shellikeri S, Ohm D, Shaw LM, Grossman M, Wolk D, McMillan CT, Chen-Plotkin A, Lee E, Trojanowski JQ, Zetterberg H, Blennow K, Irwin DJ.: CSF Biomarkers of Alzheimer Disease in Patients With Concomitant α-Synuclein Pathology. Neurology 99: e2303-e2312, Nov 2022.