Daniel T Ohm, PhD
Research Assistant Professor of Neurology
Department: Neurology
Contact information
415 Curie Blvd.
Clinical Research Building, Rm 270
Philadelphia, PA 19104
Clinical Research Building, Rm 270
Philadelphia, PA 19104
Office: 6317071953
Graduate Group Affiliations
Publications
Education:
BS (Biology, Psychology)
Syracuse University, 2008.
PhD (Neuroscience)
Northwestern University, 2019.
BS (Biology, Psychology)
Syracuse University, 2008.
PhD (Neuroscience)
Northwestern University, 2019.
Post-Graduate Training
Postdoctoral Fellow in Neurology, University of Pennsylvania Perelman School of Medicine Department of Neurology, 2019-2023.
Permanent linkPostdoctoral Fellow in Neurology, University of Pennsylvania Perelman School of Medicine Department of Neurology, 2019-2023.
Description of Research Expertise
I have expertise in human neuroanatomy, cellular and systems neuroscience, and neurodegenerative proteinopathies including Alzheimer's disease and frontotemporal lobar degeneration. I investigate patterns of pathology and neurodegeneration in large-scale neuroanatomical studies of postmortem human tissue by using a combination of novel methods including digital histopathology, computer vision, machine learning, and bioinformatic analyses. I have strong experience performing translational research with multi-disciplinary approaches designed to determine the relationships between pathologic inclusions, neurodegeneration, neuroinflammation, structural MRI, and clinical impairments characteristic of neurodegenerative disorders including behavioral variant frontotemporal dementia and primary progressive aphasia. My long-term career goal and translational research program is to support the discovery of emerging biomarkers to improve diagnostics and inform therapeutic studies dedicated to developing neuroprotective treatments in neurodegenerative disorders.Selected Publications
Khandelwal P, Duong MT, Levorse LM, Trotman W, Bahena A, Lim SA, Denning AE, Chung E, Olm CA, Radhakrishnan H, Ittyerah R, Prabhakaran K, Mizsei G, Schuck T, Emrani S, Vizcarra JA, Robinson J, Ohm DT, Phillips JS, Cohen J, Wisse LEM, Detre JA, Nasrallah IM, Brown CA, Das SR, Lee EB, Tisdall MD, Irwin DJ, McMillan CT, Wolk DA, Yushkevich PA.: Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neuropathology patterns. Alzheimers Dement Jun 2026.Irwin DJ, Emrani S, Ohm DT, Trotman W, Bahena A, Teunissen-Bermeo E, Sabatini P, Das SR, Mizsei G, Prabhakaran K, Ittyerah R, Coslett HB, Massimo L, Wolk DA, Detre JA, Gee JC, Lee EB, Yushkevich P, McMillan CT, Tisdall MD.: Clinicoanatomic localization of iron-rich gliosis in aphasic presentations of globular glial tauopathy. Brain Commun Jun 2026.
Robinson JL, Cai H, Loh NJ, Vazquez O, Khodakaramimaghsoud Z, Suh E, Van Deerlin VM, Yushkevich PA, Mechanic-Hamilton D, Xie SX, Ohm DT, Wolk DA, Irwin DJ, Phillips JS, Lee EB.: Idiotypic-susceptible Alzheimer's disease: a clinically relevant, neurofibrillary tangle subtype. Acta Neuropathol May 2026.
Ulugut H, Younes K, Montembeault M, Bertoux M, Irish M, Kumfor F, Fumagalli GG, Samanci B, Illán-Gala I, Thompson JC, Santillo AF, Englund E, Landqvist Waldö M, Riedl L, Van den Stock J, Vandenbulcke M, Vandenberghe R, Laforce R Jr, Ducharme S, Pressman PS, Caramelli P, Cruz de Souza L, Takada LT, Gurvit H, Diehl-Schmid J, Galimberti D, Pasquier F, Weintraub S, Miller BL, Sturm VE, Whitwell JL, Boeve B, Rohrer JD, Piguet O, Gorno-Tempini ML, Josephs KA, Snowden J, Rowe JB, Warren JD, Rankin KP, Pijnenburg YAL, International rtvFTD working group.: Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group. Commoun Med Dec 2025.
Sadeghpour N, Lim SA, Wuestefeld A, Denning AE, Ittyerah R, Trotman W, Chung E, Sadaghiani S, Prabhakaran K, Bedard ML, Ohm DT, Artacho-Pérula E, de Onzoño Martin MMI, Muñoz M, Romero FJM, González JCD, Del Arroyo Jiménez M, Del Marcos Rabal M, Insausti Serrano AM, González NV, Sánchez SC, de la Rosa Prieto C, Insausti R, McMillan C, Lee EB, Detre JA, Das SR, Xie L, Tisdall MD, Irwin DJ, Wolk DA, Yushkevich PA, Wisse LEM.: Developing an Anatomically Valid Segmentation Protocol for Anterior Regions of the Medial Temporal Lobe for Neurodegenerative Diseases. Hippocampus Sep 2025.
Spencer BE, Xie SX, Ohm DT, Elman L, Quinn CC, Amado DA, Baer M, Lee EB, Van Deerlin VM, Dratch L, Massimo L, Irwin DJ, McMillan CT.: Cumulative incidence of motor and cognitive features in the amyotrophic lateral sclerosis-frontotemporal degeneration spectrum. Brain Commun July 2025.
Athalye C, Bahena A, Khandelwal P, Emrani S, Trotman W, Levorse LM, Khodakarami Z, Ohm DT, Teunissen-Bermeo E, Capp N, Sadaghiani S, Arezoumandan S, Lim SA, Prabhakaran K, Ittyerah R, Robinson JL, Schuck T, Lee EB, Tisdall MD, Das SR, Wolk DA, Irwin DJ, Yushkevich PA.: Operationalizing postmortem pathology-MRI association studies in Alzheimer's disease and related disorders with MRI-guided histology sampling. Acta Neuropathol Commun May 2025.
Ohm DT, Xie SX, Capp N, Arezoumandan S, Cousins KAQ, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, McMillan CT, Irwin DJ.: Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia. Brain Jan 2025.
Denning AE, Ittyerah R, Levorse LM, Sadeghpour N, Athalye C, Chung E, Ravikumar S, Dong M, Duong MT, Li Y, Ilesanmi A, Sreepada LP, Sabatini P, Lowe M, Bahena A, Zablah J, Spencer BE, Watanabe R, Kim B, Sørensen MH, Khandelwal P, Brown C, Hrybouski S, Xie SX, de Flores R, Robinson JL, Schuck T, Ohm DT, Arezoumandan S, Porta S, Detre JA, Insausti R, Wisse LEM, Das SR, Irwin DJ, Lee EB, Wolk DA, Yushkevich PA. : Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer's disease continuum. Acta Neuropathol 148(1): 37, Sep 2024.
Khandelwal P, Duong MT, Sadaghiani S, Lim S, Denning AE, Chung E, Ravikumar S, Arezoumandan S, Peterson C, Bedard M, Capp N, Ittyerah R, Migdal E, Choi G, Kopp E, Loja B, Hasan E, Li J, Bahena A, Prabhakaran K, Mizsei G, Gabrielyan M, Schuck T, Trotman W, Robinson J, Ohm DT, Lee EB, Trojanowski JQ, McMillan C, Grossman M, Irwin DJ, Detre JA, Tisdall MD, Das SR, Wisse LEM, Wolk DA, Yushkevich PA.: Automated deep learning segmentation of high-resolution 7 Tesla postmortem MRI for quantitative analysis of structure-pathology correlations in neurodegenerative diseases. Imaging Neurosci (Camb) May 2024.