Christopher Brown, MD, PhD
Instructor A of Neurology
Department: Neurology
Contact information
University of Pennsylvania
3710 Hamilton Walk, Goddard 504
Philadelphia, PA 19104
3710 Hamilton Walk, Goddard 504
Philadelphia, PA 19104
Publications
Education:
B.A. (Biology-Neuroscience)
Washington University in St. Louis, 2011.
Ph.D. (Anatomy and Neurobiology)
University of Kentucky, 2017.
M.D.
University of Kentucky, 2019.
B.A. (Biology-Neuroscience)
Washington University in St. Louis, 2011.
Ph.D. (Anatomy and Neurobiology)
University of Kentucky, 2017.
M.D.
University of Kentucky, 2019.
Post-Graduate Training
Intern in Internal Medicine, Hospital of the University of Pennsylvania, 2019-2020.
Resident in Neurology, Hospital of the University of Pennsylvania, 2020-2023.
Permanent linkIntern in Internal Medicine, Hospital of the University of Pennsylvania, 2019-2020.
Resident in Neurology, Hospital of the University of Pennsylvania, 2020-2023.
Selected Publications
Sreepada LP, Brown CA, Das SR, Yushkevich PA, Wolk DA, McMillan CT: Biological age acceleration in Alzheimer's disease modulates relative cortical to medial temporal lobe neurodegeneration Neurobiol Aging 153: 21-29, Sep 2025.Cousins KAQ, Korecka M, Wan Y, Vulaj A, Brown C, Tropea TF, Lee EB, Tosun D, Landau SM, Okonkwo OC, Mindt MR, Weiner MW, Irwin DJ, Wolk DA, Shaw LM: Comparison of plasma p-tau217/Aβ42, p-tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease Alzheimers Dement 21(8): e70469, Aug 2025.
Brown CA, Das SR, Cousins KAQ, Tropea TF, Plotkin AC, Detre JA, Yushkevich PA, McMillan CT, Lee EB, Shaw LM, Nasrallah IM: Tau burden is best captured by magnitude and extent: Tau-MaX as a measure of global tau Alzheimers Dement 21(7): e70346, Jul 2025.
Hrybouski S, Das SR, Xie L, Brown CA, Flamporis M, Lane J, Nasrallah IM, Detre JA, Yushkevich PA, Wolk DA: BOLD amplitude correlates of preclinical Alzheimer's disease Neurobiol Aging 150: 157-171, Jun 2025.
Xie L, Das SR, Li Y, Wisse LEM, McGrew E, Lyu X, DiCalogero M, Shah U, Ilesanmi A, Denning AE, Brown CA, Cohen J, Sreepada L, Dong M, Sadeghpour N, Khandelwal P, Ittyerah R, Ravikumar S, Sadaghiani S, Hrybouski S, de Flores R, Gibson E, Yushkevich PA, Wolk DA: A multi-cohort study of longitudinal and cross-sectional Alzheimer's disease biomarkers in cognitively unimpaired older adults Alzheimer's Disease Neuroimaging Initiative 21(2): e14492, Feb 2025.
Taghvaei M, Dolui S, Sadaghiani S, Shakibajahromi B, Brown C, Khandelwal P, Xie SX, Das S, Yushkevich PA, Wolk DA, Detre JA: Regional cerebral blood flow reflects both neurodegeneration and microvascular integrity across the Alzheimer's continuum Alzheimers Dement 21(2): e14382, Jan 2025.
Shakibajahromi B, Dolui S, Brown CA, Taghvaei M, Khandelwal P, Wu Q, Sadaghiani S, Yushkevich PA, Wolk DA, Detre JA: MRI Correlates of Executive Function in Cognitively Normal Older Subjects. Alzheimers Dement Jan 2025 Notes: doi: 10.1002/alz.089690.
Sreepada LP, Brown CA, Das SR, Yushkevich PA, Wolk DA, McMillan CT: Biological aging is associated with atypical neurodegenerative patterns in Alzheimer’s disease. Alzheimers Dement Jan 2025 Notes: doi: 10.1002/alz.093413.
Cousins KAQ, Korecka M, Yang W, Vulaj A, Brown CA, Tropea TF, Chen-Plotkin A, Lee EB, Irwin DJ, Wolk DA, Shaw LM: Comparison of p-tau217 and Aβ42/Aβ40 biomarkers by race to detect Alzheimer’s disease. Alzheimers Dement Jan 2025 Notes: doi: 10.1002/alz.094605.
Brown CA, Das SR, Cousins KAQ, Tropea TF, Chen-Plotkin A, Lee EB, Nasrallah IM, Detre JA, Yushkevich PA, Shaw LM, Wolk DA: Tau Magnitude and eXtent-Tau-MaX: Capturing Tau spread and local accumulation provides a robust metric of tau burden. Alzheimers Dement Jan 2025 Notes: doi: 10.1002/alz.095756.