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Peter J. Snyder, M.D.
Professor of Medicine (Endocrinology, Diabetes and Metabolism)
Department: Medicine
Contact information
Translational Research Center, 12-135
3400 Civic Center Boulevard
Philadelphia, PA 19104-5160
3400 Civic Center Boulevard
Philadelphia, PA 19104-5160
Office: 2158980208
Fax: 2158985408
Fax: 2158985408
Email:
PJS@MAIL.MED.UPENN.EDU
PJS@MAIL.MED.UPENN.EDU
Education:
A.B. (Chemistry)
Williams College, 1961.
M.D. (Medicine)
Harvard University, 1965.
A.B. (Chemistry)
Williams College, 1961.
M.D. (Medicine)
Harvard University, 1965.
Post-Graduate Training
Intern in Medicine, Beth Israel Hospital, 1965-1966.
Junior Resident in Medicine, Beth Israel Hospital, 1966-1967.
Senior Resident in Medicine, Beth Israel Hospital, 1969-1970.
Fellow in Endocrinology, University of Pennsylvania School of Medicine, 1970-1971.
Intern in Medicine, Beth Israel Hospital, 1965-1966.
Junior Resident in Medicine, Beth Israel Hospital, 1966-1967.
Senior Resident in Medicine, Beth Israel Hospital, 1969-1970.
Fellow in Endocrinology, University of Pennsylvania School of Medicine, 1970-1971.
Certifications
American Board of Internal Medicine, Internal Medicine and Endocrinology, 1972.
Permanent linkAmerican Board of Internal Medicine, Internal Medicine and Endocrinology, 1972.
Description of Research Expertise
The Testosterone TrialThe Testosterone Trial is a multicenter study of seven coordinated trials of the effects of testosterone in elderly men with low testosterone on physical function, vitality, sexual function, cognitive function, anemia, bone and cardiovascular risk. Eight hundred men ≥65 years whose serum testosterone is <250 ng/dL are being randomized to receive testosterone or placebo double blindly for one year. The primary end points for each trial are distance walked in 6 minutes, fatigue-vitality, sexual activity, delayed verbal memory, hemoglobin, and coronary artery plaque burden. There are also several secondary end points for each trial.
The Effects of Hormones on Bone Structure
Dr. Snyder collaborates with Dr. Felix Wehrli to study the effects of hormones and other agents on bone structure as determined by magnetic resonance microimaging (µMRI). By this technique, individual trabeculae can be discerned and the topological parameters of bone can be quantitated. In addition, these data can be used to calculate bone strength by finite element analysis. Currently, the effects of testosterone, growth hormone, estradiol, teriparatide and zoledronic acid are being studied.
Pituitary Adenomas
Past studies have characterized the clinical and biochemical characteristics of gonadotroph adenomas. Currently the effect of the somatostatin analog pasireotide on gonadotroph adenoma size and secretion is being studied.
Description of Clinical Expertise
NeuroendocrinologyDr. Snyder is interested in the diagnosis and treatment of pituitary adenomas and other pituitary and hypothalamic abnormalities, including excessive and deficient pituitary hormone secretion. These conditions include acromegaly, Cushing’s disease, hyperprolactinemia, gonadotroph and other clinically nonfunctioning adenomas, other pituitary and hypothalamic tumors, hypopituitarism, and diabetes insipidus.
Male Reproductive Endocrinology
Dr. Snyder is also interested in the diagnosis and treatment of hypogonadism and infertility in men.