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Mona Al Mukaddam, M.D., M.S.
Associate Professor of Clinical Medicine (Endocrinology, Diabetes and Metabolism)
Department: Medicine
Contact information
3rd floor Penn Medicine University City
3737 Market Street
Philadelphia, PA 19104
3737 Market Street
Philadelphia, PA 19104
Office: 215-662-9905
Education:
BS
American University of Beirut, Lebanon, 2001.
MD
American University of Beirut, Lebanon, 2005.
MS
University of Pennsylvania, Institute of Translational Medicine and Therapeutics, 2013.
BS
American University of Beirut, Lebanon, 2001.
MD
American University of Beirut, Lebanon, 2005.
MS
University of Pennsylvania, Institute of Translational Medicine and Therapeutics, 2013.
Links
CME titled "First Do No Harm: Realizing Timely Diagnosis and Treatment for Patients with Fibrodysplasia Ossificans Progressiva"
Interviewed by checkrare after Palovarotene was approved by the FDA and the first and only treatment for FOP.
Report on a patient with a rare bone disease correctly diagnosed at the Penn Bone Center
Official website for International Clinical Council on Fibrodysplasia Ossificans Progressiva
Podcast on Women's Health in FOP
Penn bone Center featured in Penn Medicine Women's health newsletter
Penn Bone Center
Penn Primary Care Podcast discussing osteoporosis Hosted by Drs Amber Bird, Deepa Rani Nandiwada and Mona Al Mukaddam
Webinar for BMT organization on "Bone Health after Transplant"
Remembering Carol Orzel, FOP patient, who donated her skeleton to the the mutter museum.
CDC sponsored virtual grand round on evaluation and management of bone health in patients with Thalassemia https://www.cdc.gov/ncbddd/thalassemia/webinar-archives.html
Endocrinology Spotlight Series: Management of Calcium and Metabolic Bone Disorders Expert Guidance for Challenging Cases
Commentary regarding type 1 diabetes and bone in medpage today
Interviewed for a Penn primary care podcast to discuss osteoporosis
Webinar on COVID-19 vaccinations in FOP patients
International Fibrodysplasia Ossificans Progressiva Association
Global CME on treatment considerations in Fibrodysplasia Ossificans Progressiva (FOP)
CME titled "First Do No Harm: Realizing Timely Diagnosis and Treatment for Patients with Fibrodysplasia Ossificans Progressiva"
Interviewed by checkrare after Palovarotene was approved by the FDA and the first and only treatment for FOP.
Report on a patient with a rare bone disease correctly diagnosed at the Penn Bone Center
Official website for International Clinical Council on Fibrodysplasia Ossificans Progressiva
Podcast on Women's Health in FOP
Penn bone Center featured in Penn Medicine Women's health newsletter
Penn Bone Center
Penn Primary Care Podcast discussing osteoporosis Hosted by Drs Amber Bird, Deepa Rani Nandiwada and Mona Al Mukaddam
Webinar for BMT organization on "Bone Health after Transplant"
Remembering Carol Orzel, FOP patient, who donated her skeleton to the the mutter museum.
CDC sponsored virtual grand round on evaluation and management of bone health in patients with Thalassemia https://www.cdc.gov/ncbddd/thalassemia/webinar-archives.html
Endocrinology Spotlight Series: Management of Calcium and Metabolic Bone Disorders Expert Guidance for Challenging Cases
Commentary regarding type 1 diabetes and bone in medpage today
Interviewed for a Penn primary care podcast to discuss osteoporosis
Webinar on COVID-19 vaccinations in FOP patients
International Fibrodysplasia Ossificans Progressiva Association
Global CME on treatment considerations in Fibrodysplasia Ossificans Progressiva (FOP)
Post-Graduate Training
Intern, Internal Medicine, American University of Beirut - Medical Center, Beirut, Lebanon, 2005-2006.
Clinical Research Fellow, American University of Beirut - Medical Center, Beirut, Lebanon, 2006-2007.
Intern and Resident, Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, 2007-2010.
Fellow, University of Pennsylvania, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA, 2010-2013.
Post-Doctoral Fellow and Clinical Associate, University of Pennsylvania, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA, 2013-2014.
Intern, Internal Medicine, American University of Beirut - Medical Center, Beirut, Lebanon, 2005-2006.
Clinical Research Fellow, American University of Beirut - Medical Center, Beirut, Lebanon, 2006-2007.
Intern and Resident, Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, 2007-2010.
Fellow, University of Pennsylvania, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA, 2010-2013.
Post-Doctoral Fellow and Clinical Associate, University of Pennsylvania, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, PA, 2013-2014.
Certifications
American Board of Internal Medicine, not maintaining certification., 2010.
The International Society for Clinical Densitometry, not maintaining certification., 2012.
American Board of Endocrinology, Diabetes and Metabolism, 2012.
Permanent linkAmerican Board of Internal Medicine, not maintaining certification., 2010.
The International Society for Clinical Densitometry, not maintaining certification., 2012.
American Board of Endocrinology, Diabetes and Metabolism, 2012.
Description of Clinical Expertise
Rare bone disease with expertise in Fibrodysplasia Ossificans Progressiva and hypophosphatasia. Metabolic bone and calcium disorders including osteoporosis, Paget's disease, hypo- and hyper-parathyroidism as well as bone diseases related to transplant, medications (example aromatase inhibitors and glucocorticoids) and iron overload.Description of Research Expertise
Clinical research in Fibrodysplasia Ossificans Progressiva and hypophosphatasia.Evaluation of osteoporosis and the effects of treatment/diseases on "bone quality" using high resolution imaging of bone (uMRI).
Selected Publications
Vincent A. Verheij, Robert J. Diecidue, Esmée Botman, Joseph D. Harrington, Nobuhiko Haga, Alberto Hidalgo-Bravo, Patricia L. R. Delai, Vrisha Madhuri, Mona Al Mukaddam, Keqin Zhang, Tae-Joon Cho, Rolf Morhart, Richard Keen, Carmen L. De Cunto, Clive S. Friedman, Zvi Grunwald, Michael Zasloff, J. Coen Netelenbos, Edward Hsiao, Frederick S. Kaplan, Robert J. Pignolo, Christiaan Scott and Elisabeth Marelise W. Eekhoff: Palovarotene in fibrodysplasia ossificans progressiva: review and perspective Expert Opinion on Pharmacotherapy January 2025 Notes: https://doi.org/10.1080/14656566.2025.2452938.Edward C. Hsia, Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat, Staffan K. Berglund, Angela M. Cheung, Carmen De Cunto, Patricia Delai, Peter Kannu, Richard Keen, Edna E. Mancilla, Fei Shih, Andrew Strahs and Frederick S. Kaplan: The Impact of Palovarotene Treatment on Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva With and Without Flare-Ups: Data from the Phase III MOVE Trial and Natural History Study. Poster presentation ASBMR annual meeting, Toronto, CA Sept 2024 Notes: Poster.
Tarun Mattikalli, Rashad Madi, Steven Graham, Julio Ojea Quintana, Hannah Rosenblatt, Bruce J. Kneeland, Amna Nabeel Khan, Benjamin T. Newman, Elena Taratuta, Mona Al Mukaddam, Chamith S. Rajapakse: Using Machine Learning Algorithms for High-Risk Patient Identification in Atypical Femoral Fractures. Poster presentation ASBMR annual meeting, Toronto, CA Sept 2024 Notes: Poster.
Keen R, Dahir KM, McGinniss J, Sanchez RJ, Mellis S, Economides AN, Di Rocco M, Orcel P, Roux C, Tabarkiewicz J, Bachiller-Corral J, Cheung AM, Al Mukaddam M, Mohammadi K, Gu J, Srinivasan D, Trotter DG, Eekhoff EMW, Kaplan FS, Pignolo RJ.: Characterization of flare-ups and impact of Garetosmab in adults with Fibrodysplasia Ossificans Progressiva: a post hoc analysis of the randomized, double-blind, placebo-controlled LUMINA-1 trial. J Bone Miner Res 26(39): 1486-1492, Aug 2024 Notes: doi: 10.1093/jbmr/zjae140.
Patricia Delai, Mona Al Mukaddam, Geneviève Baujat, Carmen De Cunto, Edward C. Hsiao, Richard Keen, Kim Croskery, Jean-Luc Delhay, Christelle Pommie, Robert J. Pignolo: Incidence and management of skin adverse events in patients receiving palovarotene for the treatment of fibrodysplasia ossificans progressiva. Poster Presentation at ICCBH Salzburg, Austria June 2024.
Richard Keen, Robert J. Pignolo, Mona Al Mukaddam, Geneviève Baujat, Angela M. Cheung, Carmen De Cunto, Edward C. Hsiao, Jean-Luc Delhay, Fei Shih, Andrew Strahs, Frederick S. Kaplan: Assessments of bone mineralisation, strength and fracture of the lumbar spine in patients with fibrodysplasia ossificans progressiva treated with palovarotene: Data from the phase III MOVE trial and a phase II open-label extension Poster Presentation at ICCBH Salzburg, Austria June 2024.
Javier Ocampo Mascaro, Richie Tran, Staci Kallish, Jessica Berman, Mona Al Mukaddam: Clinical Features Of Adult Hypophosphatasia And Correlation Between Laboratory Findings And Patient’s Symptomatology: A Retrospective Review At The Penn Bone Center. Poster Session Endocrine Society Annual Meeting June 2024.
Javier Ocampo Mascaro, Pamela Wax, Mona Al Mukaddam: Adult-Onset Hypophosphatasia Presenting as Low Alkaline Phosphatase Level Following Denosumab Use for Osteoporosis. Poster Endocrine Society Annual Meeting June 2024.
Deborah Wenkert, Frederick S. Kaplan, Robert J. Pignolo, Edward C. Hsiao, Mona M Al Mukaddam, Eric Soliman, Victoria Smith, Pankaj Bhargava: ANDECAL, A Phase 2/3 study to determine the efficacy of the MMP9-inhibitor Andecaliximab to block new heterotopic ossification in FOP: Methodology for Part 1 of the Study Poster Presentation at ICCBH Salzburg, Austria June 2024.
Edna E. Mancilla, Geneviève Baujat, Mona Al Mukaddam, Javier Bachiller-Corral, Staffan K. Berglund, Carmen De Cunto, Patricia Delai, Richard Keen, Riccardo Papa, Robert J. Pignolo, Sally Lanar, Alexia Marrel, Alexander Artyomenko, Kim Croskery, Christelle Pommie, Edward C. Hsiao: The impact of palovarotene on patients with fibrodysplasia ossificans progressiva: Results from participant interviews in the phase III PIVOINE trial. Oral Presentation at ICCBH Salzburg, Austria June 2024.