Carla R Scanzello - Faculty Biosketch

Carla R Scanzello, MD, PhD

Associate Professor of Medicine (Rheumatology) at the Hospital of the University of Pennsylvania

Member, Institute for Immunology & Immune Health, Perelman School of Medicine

Member, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine

Member, Penn Center for Musculoskeletal Disorders, Perelman School of Medicine

Staff Physician, Corporal Michael J. Cresenz VA Medical Center

Co-Director, Translational Musculoskeletal Research Center , Corporal Michael J. Crescenz VA Medical Center

Associate Director, VA RR&D CReATE Motion Center, Corporal Michael J. Crescenz VA Medical Center

3 5f

Department: Medicine

4 1 23

1f Graduate Group Affiliations 8

Immunology

46 Contact information
46

Division of Rheumatology
36 University of Pennsylvania, School of Medicine
1c 5th Floor White Bldg
1a 3400 Spruce Street
9 &
1d CMC VA Medical Center
1a 3900 Woodland Ave.
33 Bldg 21, Rm A215
Philadelphia, PA 19104

36 Office: 215-823-5800 x205666
46 Lab: 215-823-5800 x207776
18

Email:
cscanz@pennmedicine.upenn.edu

4 3 3 1d

18 Publications
23

5d 6f

26 Search PubMed for articles c

3 2 4 b 1f

13 Education:
21 9 B.S. 19 (Biochemistry) c
3b University of Delaware, Newark, DE, 1991.
21 9 M.D. c
50 Temple University, School of Medicine, Philadelphia, PA, 2001.
21 9 Ph.D 26 (Immunology & Microbiology) c
50 Temple University, School of Medicine, Philadelphia, PA, 2001.
c

3 27

Links
a9 Search PubMed for articles
5b Laboratory website
c

5 21

1f Post-Graduate Training
24 7e Resident in Medicine, New York Presbyterian Hospital/ Weill-Cornell Medical Center, New York, NY, 2002-2004.
24 5f Fellow (Rheumatology), Hospital for Special Surgery, New York, NY, 2004-2008.
c

3 25

17 Certifications
28 4b American Board of Internal Medicine / Rheumatology, 2007.
c

3 8d Permanent link
2 29

b6 > Perelman School of Medicine > Faculty > Details a

1e 1d

7 29

Selected Publications

1ac Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson: Identification of a central role for complement in osteoarthritis. Nature Medicine 17(12): 1674-9, 2011.

13e Nair A, Gan J, Bush-Joseph C, Verma N, Tetreault MW, Saha K, Margulis A, Fogg L, Scanzello CR.: Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears. Osteoarthritis Cartilage 23(7): 1158-64, Jul 2015.

1ae Sambamurthy Nisha, Nguyen Vu, Smalley Ryan, Xiao Rui, Hankenson Kurt, Gan Justin, Miller Rachel E, Malfait Anne-Marie, Dodge George R, Scanzello Carla R: Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis. Journal of orthopaedic research 36(3): 864-87, March 2018.

16b Sambamurthy Nisha, Zhou Cheng, Nguyen Vu, Smalley Ryan, Hankenson Kurt D, Dodge George R, Scanzello Carla R: Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis. PloS One 13(11): e0206217, Nov 2018.

272 S Kolasinski, T Neogi, M Hochberg, C Oatis, GH Guyatt, J Block, L Callahan, C Copenhaver, C Dodge, D Felson, K Geller, W Harvey, G Hawker, E Herzig, K Kwoh, A Nelson, J Samuels, C Scanzello, D White, B Wise, R Altman, D DiRenzo, J Fontanarosa, G Giradi, M Ishimori, D Misra, A Shah, A Shmagel, L Thoma, M Turgunbaev, A Turner, J Reston.: 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip and Knee. Arthritis & Rheumatology 72(2): 220-233 Feb 2020 Notes: DOI 10.1002/art.41142.

187 S Bansal, KD Meadows,LM Miller, KS Saleh, JM Patel, BD Stoeckl, EA Lemmon, MW Hast, MH Zgonis,CR Scanzello, DM Elliott,RL Mauck: Six Month Outcomes of Clinically Relevant Meniscal Injury in a Large Animal Model. Orthopaedic Journal of Sports Medicine 9(11): 23259671211035444, Nov 2021 Notes: Accepted for publication.

1b8 CR Scanzello, KA Hasty, CB Chung, TM Griffin, NJ Willet, H Krug, Cong-Qiu Chu, D Ewart, S Jerban, JF Baker, CL Duvall, JM Brunger, JA Burdick, KP Spindler, H Drissi. : Teaming Up to Overcome Challenges in the Clinical Translation of New Therapeutics for Osteoarthritis. J Ortho Res. Online ahead of print, 42(12): 2659-2672. Dec 2024 Notes: doi: 10.1002/jor.25944.

19c AM Obeidat, SY Kim, KG Burt, B Hu, J Li, S Ishihara, R Xiao, RE Miller, C Little, AM Malfait, CR Scanzello: A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis. Osteoarthritis Cartilage. 32(10): 1273-1282, Oct 2024 Notes: doi: 10.1016/j.joca.2024.05.006.

e0 SY Kim, CR Scanzello: When “Synovitis” isn’t Synovitis. Osteoarthritis Cartilage 33(1): 1-4, Jan 2025 Notes: doi: 10.1016/j.joca.2024.09.005.

103 LA Murphy, CR Scanzello. : Cellular and molecular mechanisms underlying subchondral bone remodeling and associated pain in osteoarthritis. Connect Tissue Res. 66(5): 435-441, Aug 2025

2c

7 1d

2c back to top
26 Last updated: 04/03/2026
34 The Trustees of the University of Pennsylvania c