Christos Davatzikos, Ph.D.

Wallace T. Miller Sr. Professor of Radiology,
& Electrical and Systems Engineering

Christos Davatzikos, Ph.D.Director, Center for Biomedical Image Computing and Analytics (CBICA)
Director, Artificial Intelligence in Biomedical Imaging Lab (AIBIL)
Joint Affiliations: Bioengineering and Applied Math graduate groups

University of Pennsylvania
Richards Building, 7th Fl, Rm D705
3700 Hamilton Walk
Philadelphia PA 19104
University of Pennsylvania webpage


Research Interests

Biomedical Image Analysis, Machine learning in Imaging, Imaging Biomarkers of Neurologic and Neuropsychiatric Diseases.

Educational Qualifications

Postdoctoral Fellow, in the Department of Radiology, Johns Hopkins University School of Medicine (1994-1995)
Ph.D. in Electrical and Computer Engineering, Johns Hopkins University (1989-1994)
B.Sc. in Electrical Engineering and Computer Science, National Technical University of Athens, Greece (1985-1989)

Representative Publications

For a full list of publications check here

  1. Davatzikos C. Machine learning in neuroimaging: Progress and challenges. Neuroimage. 2019 Aug 15;197:652-656. doi: 10.1016/j.neuroimage.2018.10.003. Epub 2018 Oct 6. PubMed PMID: 30296563; PubMed Central PMCID: PMC6499712.

  2. SPRINT MIND Investigators for the SPRINT Research Group, Williamson JD, Pajewski NM, Auchus AP, Bryan RN, Chelune G, Cheung AK, Cleveland ML, Coker LH, Crowe MG, Cushman WC, Cutler JA, Davatzikos C, Desiderio L, Erus G, Fine LJ, Gaussoin SA, Harris D, Hsieh MK, Johnson KC, Kimmel PL, Tamura MK, Launer LJ, Lerner AJ, Lewis CE, Martindale-Adams J, Moy CS, Nasrallah IM, Nichols LO, Oparil S, Ogrocki PK, Rahman M, Rapp SR, Reboussin DM, Rocco MV, Sachs BC, Sink KM, Still CH, Supiano MA, Snyder JK, Wadley VG, Walker J, Weiner DE, Whelton PK, Wilson VM, Woolard N, Wright JT Jr, Wright CB. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. JAMA. 2019 Feb 12;321(6):553-561. doi: 10.1001/jama.2018.21442. PubMed PMID: 30688979; PubMed Central PMCID: PMC6439590.

  3. Eavani H, Habes M, Satterthwaite TD, An Y, Hsieh MK, Honnorat N, Erus G, Doshi J, Ferrucci L, Beason-Held LL, Resnick SM, Davatzikos C. Heterogeneity of structural and functional imaging patterns of advanced brain aging revealed via machine learning methods. Neurobiol Aging. 2018 Nov;71:41-50. doi: 10.1016/j.neurobiolaging.2018.06.013. Epub 2018 Jun 15. PubMed PMID: 30077821; PubMed Central PMCID: PMC6162110.
  4. Habes M, Sotiras A, Erus G, Toledo JB, Janowitz D, Wolk DA, Shou H, Bryan NR, Doshi J, Völzke H, Schminke U, Hoffmann W, Resnick SM, Grabe HJ, Davatzikos C. White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy. Neurology. 2018 Sep 4;91(10):e964-e975. doi: 10.1212/WNL.0000000000006116. Epub 2018 Aug 3. PubMed PMID: 30076276; PubMed Central PMCID: PMC6139818.
  5. Rozycki M, Satterthwaite TD, Koutsouleris N, Erus G, Doshi J, Wolf DH, Fan Y, Gur RE, Gur RC, Meisenzahl EM, Zhuo C, Yin H, Yan H, Yue W, Zhang D, Davatzikos C. Multisite Machine Learning Analysis Provides a Robust Structural Imaging Signature of Schizophrenia Detectable Across Diverse Patient Populations and Within Individuals. Schizophr Bull. 2018 Aug 20;44(5):1035-1044. doi: 10.1093/schbul/sbx137. PubMed PMID: 29186619; PubMed Central PMCID: PMC6101559.
  6. Varol E, Sotiras A, Davatzikos C. MIDAS: Regionally linear multivariate discriminative statistical mapping. Neuroimage. 2018 Jul 1;174:111-126. doi: 10.1016/j.neuroimage.2018.02.060. Epub 2018 Mar 7. PubMed PMID: 29524624; PubMed Central PMCID: PMC5949280.
  7. Rathore S, Akbari H, Rozycki M, Abdullah KG, Nasrallah MP, Binder ZA, Davuluri RV, Lustig RA, Dahmane N, Bilello M, O'Rourke DM, Davatzikos C. Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1. Sci Rep. 2018 Mar 23;8(1):5087. doi: 10.1038/s41598-018-22739-2. PubMed PMID: 29572492; PubMed Central PMCID: PMC5865162.
  8. Erus G, Doshi J, An Y, Verganelakis D, Resnick SM, Davatzikos C. Longitudinally and inter-site consistent multi-atlas based parcellation of brain anatomy using harmonized atlases. Neuroimage. 2018 Feb 1;166:71-78. doi: 10.1016/j.neuroimage.2017.10.026. Epub 2017 Nov 4. PubMed PMID: 29107121; PubMed Central PMCID: PMC5748021.
  9. Davatzikos C, Rathore S, Bakas S, Pati S, Bergman M, Kalarot R, Sridharan P, Gastounioti A, Jahani N, Cohen E, Akbari H, Tunc B, Doshi J, Parker D, Hsieh M, Sotiras A, Li H, Ou Y, Doot RK, Bilello M, Fan Y, Shinohara RT, Yushkevich P, Verma R, Kontos D. Cancer imaging phenomics toolkit: quantitative imaging analytics for precision diagnostics and predictive modeling of clinical outcome. J Med Imaging (Bellingham). 2018 Jan;5(1):011018. doi: 10.1117/1.JMI.5.1.011018.  Epub 2018 Jan 11. PubMed PMID: 29340286; PubMed Central PMCID: PMC5764116.
  10. Bakas S, Akbari H, Pisapia J, Martinez-Lage M, Rozycki M, Rathore S, Dahmane N, O'Rourke DM, Davatzikos C. In Vivo Detection of EGFRvIII in Glioblastoma via Perfusion Magnetic Resonance Imaging Signature Consistent with Deep Peritumoral Infiltration: The φ-Index. Clin Cancer Res. 2017 Aug 15;23(16):4724-4734. doi: 10.1158/1078-0432.CCR-16-1871. Epub 2017 Apr 20. PubMed PMID: 28428190; PubMed Central PMCID: PMC5559313.
  11. Rathore S, Habes M, Iftikhar MA, Shacklett A, Davatzikos C. A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer's disease and its prodromal stages. Neuroimage. 2017 Jul 15;155:530-548. doi: 10.1016/j.neuroimage.2017.03.057. Epub 2017 Apr 13. Review.  PubMed PMID: 28414186; PubMed Central PMCID: PMC5511557.
  12. Dong A, Toledo JB, Honnorat N, Doshi J, Varol E, Sotiras A, Wolk D, Trojanowski JQ, Davatzikos C; Alzheimer’s Disease Neuroimaging Initiative. Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers. Brain. 2017 Mar 1;140(3):735-747. doi: 10.1093/brain/aww319. PubMed PMID: 28003242; PubMed Central PMCID: PMC5837514.
  13. Varol E, Sotiras A, Davatzikos C; Alzheimer's Disease Neuroimaging Initiative. HYDRA: Revealing heterogeneity of imaging and genetic patterns through a multiple max-margin discriminative analysis framework. Neuroimage. 2017 Jan 15;145(Pt B):346-364. doi: 10.1016/j.neuroimage.2016.02.041. Epub 2016 Feb 23. PubMed PMID: 26923371; PubMed Central PMCID: PMC5408358.
  14. Habes M, Erus G, Toledo JB, Zhang T, Bryan N, Launer LJ, Rosseel Y, Janowitz D, Doshi J, Van der Auwera S, von Sarnowski B, Hegenscheid K, Hosten N, Homuth G, Völzke H, Schminke U, Hoffmann W, Grabe HJ, Davatzikos C. White matter hyperintensities and imaging patterns of brain ageing in the general population. Brain. 2016 Apr;139(Pt 4):1164-79. doi: 10.1093/brain/aww008. Epub 2016 Feb 24. PubMed PMID: 26912649; PubMed Central PMCID: PMC5006227.
  15. Akbari H, Macyszyn L, Da X, Bilello M, Wolf RL, Martinez-Lage M, Biros G, Alonso-Basanta M, OʼRourke DM, Davatzikos C. Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma. Neurosurgery. 2016 Apr;78(4):572-80. doi: 10.1227/NEU.0000000000001202. PubMed PMID: 26813856; PubMed Central PMCID: PMC4853918.
  16. Bakas S, Zeng K, Sotiras A, Rathore S, Akbari H, Gaonkar B, Rozycki M, Pati S, Davatzikos C. GLISTRboost: Combining Multimodal MRI Segmentation, Registration, and Biophysical Tumor Growth Modeling with Gradient Boosting Machines for Glioma Segmentation. Brainlesion. 2016;9556:144-155. doi: 10.1007/978-3-319-30858-6_1. PubMed PMID: 28725877; PubMed Central PMCID: PMC5513179.
  17. Dong A, Honnorat N, Gaonkar B, Davatzikos C. CHIMERA: Clustering of Heterogeneous Disease Effects via Distribution Matching of Imaging Patterns. IEEE Trans Med Imaging. 2016 Feb;35(2):612-21. doi: 10.1109/TMI.2015.2487423. Epub 2015 Oct 6. PubMed PMID: 26452275; PubMed Central PMCID: PMC4821748.
  18. Doshi J, Erus G, Ou Y, Resnick SM, Gur RC, Gur RE, Satterthwaite TD, Furth S, Davatzikos C; Alzheimer's Neuroimaging Initiative. MUSE: MUlti-atlas region Segmentation utilizing Ensembles of registration algorithms and parameters, and locally optimal atlas selection. Neuroimage. 2016 Feb 15;127:186-195. doi: 10.1016/j.neuroimage.2015.11.073. Epub 2015 Dec 8. PubMed PMID: 26679328; PubMed Central PMCID: PMC4806537.
  19. Kou Koutsouleris N, Meisenzahl EM, Borgwardt S, Riecher-Rössler A, Frodl T, Kambeitz J, Köhler Y, Falkai P, Möller HJ, Reiser M, Davatzikos C. Individualized differential diagnosis of schizophrenia and mood disorders using neuroanatomical biomarkers. Brain. 2015 Jul;138(Pt 7):2059-73. doi: 10.1093/brain/awv111. Epub 2015 May 1. PubMed PMID: 25935725; PubMed Central PMCID: PMC4572486.
  20. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. TS Group. N Engl J Med 2015; 373:2103-2116. DOI: 10.1056/NEJMoa1511939.
  21. Eavani H, Satterthwaite TD, Filipovych R, Gur RE, Gur RC, Davatzikos C. Identifying Sparse Connectivity Patterns in the brain using resting-state fMRI. Neuroimage. 2015 Jan 15;105:286-99. doi: 10.1016/j.neuroimage.2014.09.058. Epub 2014 Oct 2. PubMed PMID: 25284301; PubMed Central PMCID: PMC4262564.
  22. Sotiras A, Resnick SM, Davatzikos C. Finding imaging patterns of structural covariance via Non-Negative Matrix Factorization. Neuroimage. 2015 Mar;108:1-16. doi: 10.1016/j.neuroimage.2014.11.045. Epub 2014 Dec 12. PubMed PMID: 25497684; PubMed Central PMCID: PMC4357179.
  23. Ou Y, Akbari H, Bilello M, Da X, Davatzikos C. Comparative evaluation of registration algorithms in different brain databases with varying difficulty: results and insights. IEEE Trans Med Imaging. 2014 Oct;33(10):2039-65. doi: 10.1109/TMI.2014.2330355. Epub 2014 Jun 13. PubMed PMID: 24951685; PubMed Central PMCID: PMC4371548.
  24. Koutsouleris N, Davatzikos C, Borgwardt S, Gaser C, Bottlender R, Frodl T, Falkai P, Riecher-Rössler A, Möller HJ, Reiser M, Pantelis C, Meisenzahl E. Accelerated brain aging in schizophrenia and beyond: a neuroanatomical marker of psychiatric disorders. Schizophr Bull. 2014 Sep;40(5):1140-53. doi:10.1093/schbul/sbt142. Epub 2013 Oct 13. PubMed PMID: 24126515; PubMed Central PMCID: PMC4133663
  25. Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME; Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Investigators. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. JAMA Intern Med. 2014 Mar;174(3):324-33. doi: 10.1001/jamainternmed.2013.13656. PubMed PMID: 24493100; PubMed Central PMCID: PMC4423790.
  26. Gaonkar B, Davatzikos C. Analytic estimation of statistical significance maps for support vector machine based multi-variate image analysis and classification. Neuroimage. 2013 Sep; 78:270-83. doi: 10.1016/j.neuroimage.2013.03.066. Epub 2013 Apr 10. PubMed PMID: 23583748; PubMed Central PMCID: PMC3767485.
  27. Sotiras A, Davatzikos C, Paragios N. Deformable medical image registration: a survey. IEEE Trans Med Imaging. 2013 Jul;32(7):1153-90. doi:10.1109/TMI.2013.2265603. Epub 2013 May 31. Review. PubMed PMID: 23739795; PubMed Central PMCID: PMC3745275.
  28. Gooya A, Pohl KM, Bilello M, Cirillo L, Biros G, Melhem ER, Davatzikos C. GLISTR: glioma image segmentation and registration. IEEE Trans Med Imaging. 2012 Oct;31(10):1941-54. doi: 10.1109/TMI.2012.2210558. Epub 2012 Aug 13. PubMed PMID: 22907965; PubMed Central PMCID: PMC4371551.
  29. Launer LJ, Miller ME, Williamson JD, Lazar RM, Gerstein HC, Murray AM, Sullivan M, Horowitz KR, Ding J, Marcovina S, Lovato LC, Lovato J, Margolis KL, O'Connor P, Lipkin EW, Hirsch J, Coker L, Maldjian J, Sunshine JL, Truwit C, Davatzikos C, Bryan RN; ACCORD MIND investigators. Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol. 2011 Nov;10(11):969-77. doi: 10.1016/S1474-4422(11)70188-0. Epub 2011 Sep 28. PubMed PMID: 21958949; PubMed Central PMCID: PMC3333485.
  30. Batmanghelich NK, Taskar B, Davatzikos C. Generative-discriminative basis learning for medical imaging. IEEE Trans Med Imaging. 2012 Jan;31(1):51-69. doi:  10.1109/TMI.2011.2162961. Epub 2011 Jul 25. PubMed PMID: 21791408; PubMed Central PMCID: PMC3402718.
  31. Davatzikos C, Bhatt P, Shaw LM, Batmanghelich KN, Trojanowski JQ. Prediction of MCI to AD conversion, via MRI, CSF biomarkers, and pattern classification. Neurobiol Aging. 2011 Dec;32(12): 2322.e19-27. doi:10.1016/j.neurobiolaging.2010.05.023. Epub 2010 Jul 1. PubMed PMID: 20594615; PubMed Central PMCID: PMC2951483
  32. Zacharaki EI, Wang S, Chawla S, Soo Yoo D, Wolf R, Melhem ER, Davatzikos C. Classification of brain tumor type and grade using MRI texture and shape in a machine learning scheme. Magn Reson Med. 2009 Dec;62(6):1609-18. doi: 10.1002/mrm.22147. PubMed PMID: 19859947; PubMed Central PMCID: PMC2863141.
  33. Baloch S, Davatzikos C. Morphological appearance manifolds in computational anatomy: groupwise registration and morphological analysis. Neuroimage. 2009 Mar;45(1 Suppl):S73-85. doi: 10.1016/j.neuroimage.2008.10.048. Epub 2008 Nov 12.  PubMed PMID: 19061962; PubMed Central PMCID: PMC2871383.
  34. Zhan Y, Shen D, Zeng J, Sun L, Fichtinger G, Moul J, Davatzikos C. Targeted prostate biopsy using statistical image analysis. IEEE Trans Med Imaging. 2007 Jun;26(6):779-88. PubMed PMID: 17679329.
  35. Davatzikos C, Ruparel K, Fan Y, Shen DG, Acharyya M, Loughead JW, Gur RC, Langleben DD. Classifying spatial patterns of brain activity with machine learning methods: application to lie detection. Neuroimage. 2005 Nov 15;28(3):663-8. Epub 2005 Oct 5. PubMed PMID: 16169252
  36. Resnick SM, Pham DL, Kraut MA, Zonderman AB, Davatzikos C. Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci. 2003 Apr 15;23(8):3295-301. PubMed PMID: 12716936.
  37. Shen D, Davatzikos C. HAMMER: hierarchical attribute matching mechanism for elastic registration. IEEE Trans Med Imaging. 2002 Nov;21(11):1421-39. PubMed PMID: 12575879.