PROGRAM

Pre-event Social Hour, Monday evening, June 17

7:30 P.M.

Pay-As-You Go Social Hour, City Tap House (3925 Walnut Street)

Tuesday, June 18

Lobby and Auditorium, BRB II/III, University of Pennsylvania

Continental Breakfast and Registration

7:00 A.M. - 7:50 A.M.

Welcome and Introduction

7:50 A.M.

Lin Z. Li, Ph.D., University of Pennsylvania

Mitchell Schnall, M.D., Ph.D., University of Pennsylvania
"Life, Times, Legacy of Britton Chance"

Keynote lecture

8:00 A.M.

Kevin Brindle, Ph.D., University of Cambridge; Cancer Research UK, Cambridge Research Institute

"Studies of tumor metabolism using hyperpolarized ¹³C magnetic resonance spectroscopy"

More on Dr. Brindle

Cancer (I)
Moderator: R. Nick Bryan, M.D., Ph.D.

8:45 A.M.

Celeste Simon, Ph.D., University of Pennsylvania

"Cancer cell adaptation to metabolic stress"

9:10 A.M.

Bruce Tromberg, Ph.D., University of California, Irvine, California

"Bedside optical imaging of tissue perfusion and metabolism"

9:35 A.M.

David Mankoff, M.D., Ph.D., University of Pennsylvania

"Glucose metabolism and perfusion in human breast cancer measured by imaging: an index of therapeutic resistance?"

10:00 A.M.

Coffee Break

Blood Volume, Flow, Oxygenation, and Hypoxia
Moderators: Jerry Glickson, Ph.D. / Ravinder Reddy, Ph.D.

10:15 A.M.

Harold Swartz, M.D., Ph.D., Geisel Medical School at Dartmouth, Hanover, New Hampshire
"Repeated measurements of pO₂ in human subjects"

 

10:40 A.M.

Felix Wehrli, Ph.D., University of Pennsylvania
"Time-resolved MRI oximetry for quantifying CMRO₂ and vascular reactivity"

11:05 A.M.

Arjun Yodh, Ph.D., University of Pennsylvania
"Optical cerebral blood flow and hemoglobin concentration monitoring in brain"

11:30 A.M.

Eiji Takahashi, Ph.D., Saga University, Japan
"Imaging the gradients of oxygen in cells and tissues using GFP"

Flash Highlights of Posters
Introduction to selected posters by Rong Zhou, Ph.D. / David Busch, Ph.D.

11:55 A.M.

Short summary of selected posters, 2 minutes each

Lunch Break

12:20 P.M. - 1:35 P.M.

Lunch break and poster viewing

Glycolysis
Moderator: David Boas, Ph.D.

1:35 P.M.

Nimmi Ramanujam, Ph.D., Duke University

"Simultaneously quantifying tumor oxygenation and glycolysis in vivo via quantitative spectroscopy"

2:00 P.M.

Abass Alavi, M.D., Ph.D., University of Pennsylvania

"Revolutionary impact of FDG-PET imaging on biological research and practice of medicine"

2:25 P.M.

Jerry D. Glickson, Ph.D., University of Pennsylvania

"Tumor acidification as a treatment approach"

2:50 P.M.

Coffee Break

Liver / Lung / Kidney
Moderator: Xingde Li, Ph.D.

3:00 P.M.

Morris Birnbaum, M.D., Ph.D., University of Pennsylvania

"The regulation of hepatic metabolism"

3:25 P.M.

Steve Kadlececk, Ph.D., University of Pennsylvania

"Measurement and modeling of lung metabolism using hyperpolarized ¹³C"

3:50 P.M.

Yu Chen, Ph.D., University of Maryland

"Intra-operative assessment of transplant kidney function using optical methods"

Novel Techniques (1)
Moderator: Kyung Kang, Ph.D.

4:15 P.M.

Linda Powers, Ph.D., University of Arizona

"Real-time in-situ detection of microbes – from discovery to diagnostics"

4:40 P.M.

Eva Sevick-Muraca, Ph.D., The University of Texas Health Science Center at Houston
"Discovery in translation: near-infrared fluorescence lymphatic imaging"

5:05 P.M.

Xingde Li, Ph.D., Johns Hopkins University

"Multiphoton micro imaging"

Panel: Key Issues in Metabolic Imaging / Spectroscopy Research

5:30 P.M. - 6:15 P.M.

Emily Conant, M.D., University of Pennsylvania
Jeffrey Evelhoch, Ph.D., Merck Research Laboratories
David Mankoff, M.D., Ph.D., University of Pennsylvania

Eva Sevick-Muraca, Ph.D., The University of Texas Health Science Center at Houston

Stephen Tang, Ph.D., University City Science Center
Bruce Tromberg, Ph.D., University of California, Irvine
Huiming Zhang, Ph.D., National Cancer Institute

Reception

7:00 – 9:00 P.M.

American Philosophical Society, Benjamin Franklin Hall
427 Chestnut Street, Philadelphia, PA

SPEAKERS:

Clyde F. Barker, MD, American Philosophical Society
Helen Davies, Ph.D., University of Pennsylvania
Mark R. Chance, PhD Case Western Reserve University
Tomoko Ohnishi, PhD, University of Pennsylvania
John M. Maris, MD, Children's Hospital of Philadelphia
Duane F. Bruley, PhD, University of Maryland, Baltimore

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Wednesday, June 19

Lobby and Auditorium, BRB II/III, University of Pennsylvania

Breakfast

7:00 A.M. – 7:50 A.M.

Breakfast and Registration

Introduction

7:50 A.M.

Arjun Yodh, Ph.D., University of Pennsylvania

Keynote Speech

7:55 A.M.

Douglas C. Wallace, Ph.D., Children's Hospital of Philadelphia
"Mitochondrial medicine and metabolic diseases"

More information on Dr. Wallace

Mitochondria / Redox State
Moderator: Shoko Nioka, M.D., Ph.D. / Lihong Wang, Ph.D.

8:35 A.M.

Robert S. Balaban, Ph.D., National Institute of Heart, Lung, Blood Institute, Maryland
"The systems biology of the mitochondria"

9:00 A.M.

Lin Z. Li, Ph.D., University of Pennsylvania
"Imaging redox state as diagnostic/prognostic biomarkers"

 

9:25 A.M.

Murali Krishna Cherukuri, Ph.D., National Cancer Institute

"Nitroxide-based EPR/MRI imaging of redox status in vivo"

9:50 A.M.

Chris Cooper, Ph.D., University of Essex
"NIR spectroscopy of cytochrome c oxidase"

10:15 A.M.

Coffee break

Cancer (2)
Moderator: Hanli Liu, Ph.D.

10:30 A.M.

Peter Vaupel, M.D., Ph.D., University Medical Center, Mainz, Germany
"Hypoxia in tumors: Pathogenesis-related classification, characterization, and clinical implications"

10:55 A.M.

John Kurhanewicz, Ph.D., University of California San Francisco, California

"Hyperpolarized ¹³C MR of prostate cancer in the clinic"

11:20 A.M.

Brian Pogue, Ph.D., Dartmouth College

"Receptor concentration imaging in vivo: imaging molecules not perfusion"

Flash Highlights of Posters
Introduction to selected posters by Brian Saltzberg, Ph.D. / He N. Xu, Ph.D.

11:45 P.M.

Short summary of selected posters, 2 minutes each

Lunch Break and Poster Viewing

12:15 P.M.- 1:35 P.M.

Lunch break and poster viewing

Brain
Moderators: Qingming Luo, Ph.D. / Joseph LaManna, Ph.D.

1:35 P.M.

Hanli Liu, Ph.D., University of Texas, Arlington

"Brain atlas-guided volumetric diffuse optical tomography to study human cognitive functions"

2:00 P.M.

Qingming Luo, Ph.D., Huazhong University of Science and Technology; Britton Chance Center for Biomedical Photonics, China
"Optical imaging: from brain function to neural connectivity"

2:25 P.M.

Maria Angela Franceschini, Ph.D. Massachusetts General Hospital, Harvard Medical School

"Neonatal applications of advanced NIRS"

2:50 P.M.

John Detre, M.D., University of Pennsylvania
"CBF as a biomarker of brain function"

3:15 P.M.

David Boas, Ph.D., Harvard Medical School, Massachusetts General Hospital, Massachusetts.

"Optical microscopy of cerebral energy metabolism"

3:40 P.M.

Michelle Puchowicz, Ph.D. Case Western Reserve University
"Metabolic effects of ketosis on cerebral glucose consumption"

4:05 P.M.

Break

Novel Techniques (2)
Moderator: Andrew Tsoukas, Ph.D.

4:20 P.M.

Ravinder Reddy, Ph.D., University of Pennsylvania
"Recent advances in CEST-MRI"

4:45 P.M.

Warren Warren, Ph.D. Duke University
"Improving contrast in molecular imaging: long-lived hyperpolarized magnetic resonance and nonlinear optics"

5:10 P.M.

Lihong Wang, Ph.D., Washington University in St. Louis

"Photoacoustic tomography: Ultrasonically breaking through optical diffusion and diffraction limits"

Presentation of Poster Awards and Summary

5:35 P.M.

Arjun Yodh, Ph.D. / Brian Pogue, Ph.D. / Lin Li, Ph.D.