Welcome to the Department of Biochemistry and Biophysics
As one of the first departments of Biochemistry and Biophysics in the nation, we are proud of our strong tradition of combining cutting-edge technology with impactful biology. We continue to leverage this interdisciplinary approach to yield break-through discoveries in biomedicine.
Our faculty of over 30 primary and secondary members cover a broad range of research areas, with particular strengths in structural biology, chemical biology, gene regulation and protein folding.
We are also the proud home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction to researchers across campus.
We are actively growing, with several recent hires, and our faculty are broadly engaged across campus with many joint appointments in other departments, institutes and centers.
We welcome you to learn more about our department in the following pages or contact us.
News & Publications
- Van Duyne and Gupta in JMB
Greg Van Duyne and Kushol Gupta provide new structural insight into the integrases that promote viral integration into host genomes
- Shorter in Molecular Cell
New paper by Jim Shorter and Nancy Bonini show PARP inhibitors limit TDP-43 aggregation
- Marmorstein and Gupta in Nature Communications
Marmorstein, Gupta, and collaborators uncover the architecture of the HIRA complex required for accurate chromatin composition
- Shorter in PNAS
JIM SHORTER helps identify more roles for amyloid fibrils in viral infection
Seminars & Events
- Raiziss Rounds
September 27, 12 noon | Jeremy Wilusz, PhD
Circular RNAs and other unexpected outputs of protein-coding genes
- Friday Research Discussion
September 28, 3:30 pm | Holzbaur Lab
Express shipping and localized delivery in neurons: tuning of microtubule motors by adaptors and cytoskeletal dynamics regulates intracellular trafficking
- Thesis Defense | Christine George
October 1, 2018, 1:00 pm | Class of '62 Auditorium
- 2018 Biochemistry & Biophysics/BMB Retreat
November 8 & 9
Skytop Lodge, Poconos • Register now!
Ben Black, PhD
Ben Black, newly promoted Professor, and his team are answering some of the most pressing questions in chromosome biology, such as: How does genetic inheritance actually work? How was epigenetic information transmitted to our parents? And can building new artificial chromosomes help us understand how natural chromosomes work?The Black lab has made seminal discoveries regarding the physical basis for how CENP-A-containing nucleosomes epigenetically mark and maintain centromere location on the chromosome. Recently they have also discovered how amplified centromeric DNA repeats act as selfish elements in female meiosis to explain rapid centromere evolution.
© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.