Welcome to the Department of Biochemistry and Biophysics
As one of the first departments of Biochemistry and Biophysics in the nation, we are proud of our strong tradition of combining cutting-edge technology with impactful biology. We continue to leverage this interdisciplinary approach to yield break-through discoveries in biomedicine.
Our faculty of over 30 primary and secondary members cover a broad range of research areas, with particular strengths in structural biology, chemical biology, gene regulation and protein folding.
We are also the proud home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction to researchers across campus. We are actively growing, with several recent hires, and our faculty are broadly engaged across campus with many joint appointments in other departments, institutes and centers.
We welcome you to learn more about our department in the following pages or contact us.
Spotlight
Sgourakis Lab Awarded 2024 Cancer Grand Challenges Funding
The Sgourakis Lab has been chosen to join a global team that is being awarded Cancer Grand Challenges funding to find treatments for some of the most impenetrable childhood cancers. Co-founded by the National Cancer Institute (NCI) and Cancer Research UK, the initiative selected five teams — chosen from 176 initial applicants — to receive grants of up to $25 million. The Sgourakis Lab is investigating T-cell receptors as part of Team MATCHMAKERS. They will contribute their structural biology expertise and enhance their work using the university's new, state-of-the-art spectrometer. Read more about the CHOP researchers participating in the Cancer Grand Challenges here.
News & Publications
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Taabazuing Lab in Cells
Friday, February 16, 2024
New paper from the Taabazuing Lab, "Harnessing Pyroptosis for Cancer Immunotherapy"
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Bernstein Lab in DNA Repair
Friday, March 1, 2024
New paper from the Bernstein Lab, "Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site"
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Black Lab in Elife
Friday, March 8, 2024
New paper from the Black Lab, "Structural basis for the phase separation of the chromosome passenger complex"
Seminars & Events
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Raiziss Rounds Seminars
Our Spring 2023 Raiziss Rounds Seminar Series will begin on January 12th and will continue on Thursdays at 12:00 noon until May 25th. The full seminar schedule can be found on our Raiziss Rounds page.
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Friday Research Discussions
Friday Research Discussions occur every Friday at 4:00pm in the JF Library. View the full schedule for the semester here.