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biochemistry and biophysics

little piece of scienceThe mission of the Department of Biochemistry and Biophysics at Penn Medicine is to promote and execute the highest quality research and education in the quantitative understanding of molecular mechanism in biology and medicine.

The Department is home to the largest concentration of expertise in modern quantitative biochemistry, biophysics and structural biology on campus – with faculty who are international leaders in these areas. The overarching goal of the Department is to use these disciplines to understand molecular mechanism in medicine and how to exploit this understanding for therapeutic purposes. Central to this mission is collaboration with other parts of the Penn research community. Ultimately, details of molecular mechanism underlie explanations of all disease processes and therapies. The Department of Biochemistry and Biophysics seeks to provide these explanations and to work with other scientists at Penn and elsewhere to exploit them in advancing biomedical research.

moleculeInsideThe faculty of the Department of Biochemistry and Biophysics hold many awards and honors. The Department has two members of the National Academy of Sciences (Englander and Dreyfuss), one Fellow of the Royal Society of London (Dutton), two HHMI Investigators (Dreyfuss and Van Duyne), and two Fellows of the Biophysical Society (Wand and Englander). Recent awards include: 2012 Christian R. and Mary F. Lindback Award for Distinguished Teaching (Lewis), 2012 Protein Society Dorothy Crowfoot Hodgkin Award (Lemmon), and Michael S. Brown New Investigator Award for 2012 (Shorter) and 2011 (Black).


Answer to Trivia Question

It can't pass the brain-blood barrier


Why can’t the brain use the serotonin supply made in the gastrointestinal tract?


A collaborative study between University of Pennsylvania and The Children's Hospital of Philadelphia has been published online in Cancer Cell. The authors look for more effective treatments against childhood cancers by targeting mutations of the ALK gene. Mark Lemmon and his lab worked with Yaël P. Mossé of CHOP and Ravi Radhakrishnan of the Department of Bioengineering on the project.
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PENNMedicine profiled Les Dutton in its Fall 2014 issue. The article entitled "Man of Many (P)arts" highlights his science and his artwork.gray line
Jeremy Wilusz's work describing how a cell “decides” to make circular RNAs was recently published in Genes and Development and highlighted on the Penn Medicine News Blog site. gray line

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