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biochemistry and biophysics
Ben Black image

red dots identify
centromere location
on chromosome

The Department of Biochemistry and Biophysics can be traced back to the founding of the University of Pennsylvania’s College of Medicine in 1765, the oldest in the United States. Today, the Department’s faculty carry out research that combines cutting-edge technologies with impactful biology to gain a mechanistic understanding of biology at levels that can be translated to practical benefits in medicine and clinic.

The Department faculty engage in collaborations across the Perelman School of Medicine, as well as the Schools of Arts and Science, Engineering and Applied Sciences, and the adjoining Children’s Hospital of Philadelphia (CHOP), to partner expertise in physical biochemistry and structural biology with the strength of exceptional colleagues across many disciplines.

Marmorstein Image

histone acetyltransferase complex

The Department is the home of the Eldridge Reeves Johnson Research Foundation which offers advanced physical instrumentation and instruction for faculty, students, and postdocs. Faculty are also active in the teaching and training of PhD and medical students through the many graduate programs of the Biomedical Graduate Studies (BGS) and the Medical School.

 

2017 Department of Biochemistry and Biophysics Retreat, November 9-10
Find out more.

Congratulations to BEN BLACK, Associate Professor in the department, for being the recipient of the inaugural Dean’s Innovation Award in recognition of his outstanding and creative research!

RONEN MARMORSTEIN received a $2.5 million dollar grant for the creation of a state-of-the-art cryogenic electron microscopy facility. Read more

In a collaborative effort published
in Nature Communications,
BENJAMIN GARCIA
and RONEN MARMORSTEIN present a comprehensive profile of histone acetylation marks and the mechanisms used to generate them.
Read more.

RONEN MARMORSTEIN and colleagues describe the interaction of the acetylase NatA with the ribosome. Read more.

NICOLAI DOLIBA and FRANZ MATSCHINSKY uncover new mechanisms of glucolipotoxicity in type 2 diabetes. Read more.

KUSHOL GUPTA and GREG VAN DUYNE use crystallography to shed new light on the mechanisms of Listeria bacteriophage integration. Read more.

In a recent paper in Nat Struct Mol Biol, GIDEON DREYFUSS and his lab identify a new activity of U1 telescripting in maintaining expression of genes with long introns, and show how this activity allows for intron expansion in metazoans and differential gene expression under stress conditions.

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Tenure-Track Assistant Professor Position Open. More information

2017 – TRUSTEES OF THE UNIVERSITY OF PENNYSYLVANIA