Home

The Douglas Lab is a basic and translational laboratory in the Department of Otorhinolaryngology at the University of Pennsylvania focused on investigating the causes of olfactory dysfunction. Our work occurs at the intersection of epithelial biology, neuroscience, virology, and immunology. We utilize techniques such as three-dimensional organoid culture, immunofluorescence, and live cell imaging to characterize in vivo and in vitro alterations in the olfactory epithelium following insult (e.g., viral infection). Our goal is to better understand the causes of olfactory dysfunction and identify targets for therapeutic intervention.