Mouse Phenotyping, Physiology and Metabolism Core

The Mouse Phenotyping, Physiology and Metabolism Core provides investigators of the Penn Diabetes and Endocrinology Research Center (DRC) with access to state-of-the-art, timely and cost-effective resources for performing metabolic studies in mice.

Core Statement:

Organismal metabolism is regulated by a complex interplay between multiple organ systems, environment, and diet. We provide state of the art services, innovative techniques, and helpful consultation to both experienced and novice investigators with regards to metabolic questions.

Core Services:

Glucose homeostasis

• Clamp techniques
• Glucose tolerance test
• Insulin tolerance test
• Pyruvate tolerance test

Energy Homeostasis:

• Energy expenditure
• Fatty acid oxidation
• Exercise testing

vivo metabolic labeling and flux:

• Stable isotope infusion
• Enzyme kinetics
• Metabolic flux

Body composition:

• NMR
• DEXA

Core Acknowledgement:

Kindly acknowledge the MPPM core when presenting or publishing data obtained using our services. We are supported in part by Penn Diabetes Research Center grant P30-DK19525.  Thank you.