Publication

Zhang, H., Xue, C., Shah, R., Bermingham, K., Hinkle, C. C., Li, W., Rodrigues, A., Tabita-Martinez, J., Millar, J. S., Cuchel, M., Pashos, E. E., Liu, Y., Yan, R., Yang, W., Gosai, S. J., Vandorn, D., Chou, S. T., Gregory, B. D., Morrisey, E. E., … Reilly, M. P. (2015). Functional Analysis and Transcriptomic Profiling of iPSC-Derived Macrophages and Their Application in Modeling Mendelian Disease. Circulation Research, 117(1), 17–28. https://doi.org/10.1161/CIRCRESAHA.117.305860

Cayo, M. A., Mallanna, S. K., di Furio, F., Jing, R., Tolliver, L. B., Bures, M., Urick, A., Noto, F. K., Pashos, E. E., Greseth, M. D., Czarnecki, M., Traktman, P., Yang, W., Morrisey, E. E., Grompe, M., Rader, D. J., & Duncan, S. A. (2017). A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia. Cell Stem Cell, 20(4), 478-489.e5. https://doi.org/10.1016/j.stem.2017.01.011

McCauley, K. B., Alysandratos, K. D., Jacob, A., Hawkins, F., Caballero, I. S., Vedaie, M., Yang, W., Slovik, K. J., Morley, M., Carraro, G., Kook, S., Guttentag, S. H., Stripp, B. R., Morrisey, E. E., & Kotton, D. N. (2018). Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem Cell Reports, 10(5), 1579–1595. https://doi.org/10.1016/j.stemcr.2018.03.013

Kanchan, K., Iyer, K., Yanek, L. R., Carcamo-Orive, I., Taub, M. A., Malley, C., Baldwin, K., Becker, L. C., Broeckel, U., Cheng, L., Cowan, C., D’Antonio, M., Frazer, K. A., Quertermous, T., Mostoslavsky, G., Murphy, G., Rabinovitch, M., Rader, D. J., Steinberg, M. H., … Mathias, R. A. (2020). Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. Stem Cell Research, 46. https://doi.org/10.1016/j.scr.2020.101803

Li, Y., Renner, D. M., Comar, C. E., Whelan, J. N., Reyes, H. M., Leonardo Cardenas-Diaz, F., Truitt, R., Hui Tan, L., Dong, B., Dionysios Alysandratos, K., Huang, J., Palmer, J. N., Adappa, N. D., Kohanski, M. A., Kotton, D. N., Silverman, R. H., Yang, W., Morrisey, E. E., Cohen, N. A., & Weiss, S. R. (2021). SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. https://doi.org/10.1073/pnas.2022643118/-/DCSupplemental

Mellis, I. A., Edelstein, H. I., Truitt, R., Goyal, Y., Beck, L. E., Symmons, O., Dunagin, M. C., Linares Saldana, R. A., Shah, P. P., Pérez-Bermejo, J. A., Padmanabhan, A., Yang, W., Jain, R., & Raj, A. (2021). Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Cell Systems, 12(9), 885-899.e8. https://doi.org/10.1016/j.cels.2021.07.003

Shah, P. P., Lv, W., Rhoades, J. H., Poleshko, A., Abbey, D., Caporizzo, M. A., Linares-Saldana, R., Heffler, J. G., Sayed, N., Thomas, D., Wang, Q., Stanton, L. J., Bedi, K., Morley, M. P., Cappola, T. P., Owens, A. T., Margulies, K. B., Frank, D. B., Wu, J. C., … Jain, R. (2021). Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell, 28(5), 938-954.e9. https://doi.org/10.1016/j.stem.2020.12.016

Fernandez, R. J., Gardner, Z. J. G., Slovik, K. J., Liberti, D. C., Estep, K. N., Yang, W., Chen, Q., Santini, G. T., Perez, J. v., Root, S., Bhatia, R., Tobias, J. W., Babu, A., Morley, M. P., Frank, D. B., Morrisey, E. E., Lengner, C. J., & Johnson, F. B. (2022). GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells. ELife, 11. https://doi.org/10.7554/eLife.64430

Jiang, C. L., Goyal, Y., Jain, N., Wang, Q., Truitt, R. E., Coté, A. J., Emert, B., Mellis, I. A., Kiani, K., Yang, W., Jain, R., & Raj, A. (2022). Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells. Genome Biology, 23(1). https://doi.org/10.1186/s13059-022-02654-6

Kee, J., Thudium, S., Renner, D. M., Glastad, K., Palozola, K., Zhang, Z., Li, Y., Lan, Y., Cesare, J., Poleshko, A., Kiseleva, A. A., Truitt, R., Cardenas-Diaz, F. L., Zhang, X., Xie, X., Kotton, D. N., Alysandratos, K. D., Epstein, J. A., Shi, P. Y., … Korb, E. (2022). SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature, 610(7931), 381–388. https://doi.org/10.1038/s41586-022-05282-z

Sakata, Y., Cheng, K., Mayama, M., Seita, Y., Detlefsen, A. J., Mesaros, C. A., Penning, T. M., Shishikura, K., Yang, W., Auchus, R. J., Strauss, J. F., & Sasaki, K. (2022). Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells. Developmental Cell, 57(22), 2566-2583.e8. https://doi.org/10.1016/j.devcel.2022.10.010

Almad, A. A., Garcia, L., Takanohashi, A., Gagne, A., Yang, W., Ann McGuire, J., French, D., & Vanderver, A. (2023). Generation of three induced Pluripotent Stem Cell lines from individuals with Hypomyelination with Atrophy of Basal Ganglia and Cerebellum caused by a c.745G>A (p.D249N) autosomal dominant mutation in TUBB4A. Stem Cell Research, 69. https://doi.org/10.1016/j.scr.2023.103083

Cotticelli, M. G., Xia, S., Truitt, R., Doliba, N. M., Rozo, A. v., Tobias, J. W., Lee, T., Chen, J., Napierala, J. S., Napierala, M., Yang, W., & Wilson, R. B. (2023). Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response. DMM Disease Models and Mechanisms, 16(5). https://doi.org/10.1242/dmm.049497

Das, S., Hilman, M. C., Yang, F., Mourkioti, F., Yang, W., & Cullen, D. K. (2024). Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes. Skeletal Muscle, 14(1). https://doi.org/10.1186/s13395-024-00336-4

Jain, N., Goyal, Y., Dunagin, M. C., Cote, C. J., Mellis, I. A., Emert, B., Jiang, C. L., Dardani, I. P., Reffsin, S., Arnett, M., Yang, W., & Raj, A. (2024). Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells. Cell Systems, 15(2), 109-133.e10. https://doi.org/10.1016/j.cels.2024.01.001

Trang, K. B., Chesi, A., Toikumo, S., Pippin, J. A., Pahl, M. C., O’Brien, J. M., Amundadottir, L. T., Brown, K. M., Yang, W., Welles, J., Santoleri, D., Titchenell, P. M., Seale, P., Zemel, B. S., Wagley, Y., Hankenson, K. D., Kaestner, K. H., Anderson, S. A., Kayser, M. S., … Grant, S. F. A. (2024). Shared and unique 3D genomic features of substance use disorders across multiple cell types. https://doi.org/10.1101/2024.07.18.24310649

Trang, K. B., Pahl, M. C., Pippin, J. A., Su, C., Littleton, S. H., Sharma, P., Kulkarni, N. N., Ghanem, L. R., Terry, N. A., O’Brien, J. M., Wagley, Y., Hankenson, K. D., Jermusyk, A., Hoskins, J. W., Amundadottir, L. T., Xu, M., Brown, K. M., Anderson, S. A., Yang, W., … Grant, S. F. A. (2024). 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity. MedRxiv : The Preprint Server for Health Sciences. https://doi.org/10.1101/2023.08.30.23294092

Trang, K. B., Sharma, P., Cook, L., Mount, Z., Thomas, R. M., Kulkarni, N. N., Pahl, M. C., Pippin, J. A., Su, C., Kaestner, K. H., O’Brien, J. M., Wagley, Y., Hankenson, K. D., Jermusyk, A., Hoskins, J. W., Amundadottir, L. T., Xu, M., Brown, K. M., Anderson, S. A., … Wells, A. D. (2024). 3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility. https://doi.org/10.1101/2024.08.12.24311676