UPenn Digestive and Liver Center
The mission of the UPenn Digestive and Liver Center is to unite investigators with interests in digestive and liver disease in the exploration of creative experimental approaches, as well as to stimulate others to enter these areas of research. The scientific focus of the Center revolves around host-environmental interactions in digestive and liver disease research from bench to bedside. The Center is divided into three thematic areas: Intestinal Biology, Liver Biology, and the Microbiome. Center resources include five biomedical research cores to support research in both model systems and human subjects, a pilot & feasibility program, and various enrichment activities including a weekly seminar series, liver and intestinal stem cell clubs, and an annual retreat.
If you would like to become a member, please submit the requested information enclosed in our membership application.
Announcements
Message from Our New Center Director, Ken Cadwell!
Dear Colleagues and Friends,
I am honored to step into the role of Director of the UPenn Digestive and Liver Center and to have the opportunity to serve such an accomplished community. As I begin this new chapter, I first want to express my deep gratitude to Dr. Gary Wu for his exceptional leadership and dedication over the years. Gary’s contributions have been instrumental in shaping the Center’s success, and I am delighted that he has graciously agreed to continue serving as a co-Associate Director alongside Dr. Becky Wells. I am lucky to have their guidance as we build on the strong foundation they have established and navigate the challenges that may arise during this politically volatile period.
This edition of our quarterly newsletter brings exciting updates, including the announcement of our pilot award winners. The selection process was highly competitive, with a remarkable number of outstanding applications. This is a testament to the innovative research happening across our community. Congratulations to the awardees; your work embodies the excellence we strive to foster.
You may also notice that we’ve simplified our name to the UPenn Digestive and Liver Center, a change intended to make our identity clearer and easier to remember while staying true to our mission.
In my new role, I am committed to supporting our excellent core services and promote community building through the many enrichment activities organized by the Center. I look forward to working with all of you to drive our Center’s continued growth and impact.
Warm regards, Ken
Grant Citation
Please cite the UPenn Digestive and Liver Center (P30DK050306) in all publications related to core usage.
NOT-DK-24-031: “Availability of Administrative Supplements to Broaden the NIDDK Clinical Research Workforce":
This administrative supplement is designed to broaden the clinical research workforce with a specific focus on research coordinators. The supplement will provide funds to hire, train and support clinical research coordinators for up to two years to improve the outreach, recruitment, and community engagement of NIDDK clinical research studies, leading to more transformative research.
NIDDK Strategic Plan for Research
To review the NIDDK Strategic Plan for Research, click here.
Check out this NIDDK Resource Website (dkNET): https://dknet.org/
dkNET is a search portal funded by NIDDK that helps researchers find research resources relevant to their research and keep up to date on new tools, services and mandates to support robust and reproducible science. Research resources include reagents, organisms, software tools, databases and services.
Latest Publications from Center Members
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Microbial and Proteomic Signature of Acute Cellular Rejection in Lung Transplants
Saturday, September 12, 2026
CONCLUSIONS: This study identified microbial and host biomarkers of ACR. We detected candidate biomarkers that underscore the mechanistic implications of complement and fibrinogen in ACR and that may be useful as future diagnostic tools for ACR.
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Impaired regulation by purinergic signaling axis contributes to CD8+ T cell dysregulation in STAT3 gain of function
Tuesday, September 8, 2026
Gain-of-function (GOF) variants in STAT3 cause a complex disorder characterized by early-onset autoimmunity, lymphoproliferation, recurrent infections, and immune dysregulation. In both primary human and mouse models of STAT3 GOF, CD8+ T cells have been implicated as pathogenic drivers of autoimmunity, though the exact mechanisms remain poorly understood. Here, we found that in patients with STAT3 GOF, CD8+ T cells exist in an activated state. Functional assessment revealed that naive CD8+ T...
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Discovery Stack Pilot demonstrates the feasibility and outcomes of a scientist-designed peer-review model that separates quality and impact
Tuesday, September 8, 2026
Peer review serves as the cornerstone of scientific quality control. Yet, the current journal-centric system is hindered by long timelines, high publication costs, inconsistent review quality, systemic biases, and editorial gatekeeping. Notably, the system relies on misaligned measures of impact that are tethered to journal branding and conflate scientific rigor (Quality) with perceived significance (Impact). Here, we report findings from the Discovery Stack Pilot Study, which tested a...