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Eddie was a graduate student in the lab. He was in the Pharmacology Graduate Group. Eddie graduated from Colby College in 2014 with a BA in biochemistry and mathematics. He is from Boston and a Celtics and Patriots fan. Eddie's hobbies include skiing, rock climbing, and ultimate frisbee. He is super excited to try out all the local food and craft beers in Philly. In 2018, Eddie won a Blavatnik Family Fellowship in Biomedical Research. In 2019, Eddie won the John S. O'Brien Award for best oral presentation at the annual PGG Retreat. Eddie defended his Ph.D. thesis 'Pharmacological stimulation of the human Hsp70 protein-disaggregase system'  in August, 2020. Eddie went on to pursue a post-doc with Monica Driscoll at Rutgers University.

Publications

Cupo, R.R.*, A. Rizo*, G.A. Braun, E. Tse, E. Chuang, D.R. Southworth, and J. Shorter. (2022). Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3. BioRxiv. doi:. pdf file link (*Co-first author.).

March, Z.M., K. Sweeney°, H. Kim°, X. Yan°, L.M. Castellano, M.E. Jackrel, J. Lin, E. Chuang, E. Gomes, C. W. Willicott, K. Michalska, R. Jedrzejczak, A. Joachimiak, K.A. Caldwell, G.A. Caldwell, O. Shalem, and J. Shorter. (2020). Therapeutic genetic variation revealed in diverse Hsp104 homologs. eLife. 9:e57457. pdf file link (°Co-second author).

Mack, K.L.*, H. Kim*, M.E. Jackrel, J. Lin, J.E. DeNizio, X. Yan, E. Chuang, A. Tariq, R.R. Cupo, L.M. Castellano, K.A. Caldwell, G.A. Caldwell, and J. Shorter. (2020). Tuning Hsp104 specificity to selectively detoxify α-synuclein. BioRxiv. doi: 10.1101/2020.04.15.043935. pdf file link (*Co-first author.).

Jones, R.D., C. Enam, R. Ibarra, H.R. Borror, K.E. Mostoller, E.K. Fredrickson, J. Lin, E. Chuang, Z. March, J. Shorter, T. Ravid, G. Kleiger, and R.G. Gardner. (2020). The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Mol. Biol. Cell. 31(3):221-233. pdf file link

Michalska, K.*, K. Zhang*, Z.M. March*, C. Hatzos-Skintges, G. Pintilie, L. Bigelow, L.M. Castellano, L.J. Miles, M.E. Jackrel, E. Chuang, R. Jedrzejczak, J. Shorter, W. Chiu, and A. Joachimiak. (2019). Structure of Calcarisporiella thermophila Hsp104 disaggregase that antagonizes diverse proteotoxic misfolding events. Structure. 27(3):4490463. pdf file link (*Co-first author).

Chuang, E.*, A.M. Hori*, C.D. Hesketh*, and J. Shorter. (2018). Amyloid assembly and disassembly. J. Cell. Sci. doi: 10.1242/jcs.189928. pdf file link (*Co-first author).

Gates, S.N*., A.L. Yokom*, J. Lin, M.E. Jackrel, A.N. Rizo, N.M. Kendsersky, C.E. Buell, E.A. Sweeny, K.L. Mack, E. Chuang, M.P. Torrente, M. Su, J. Shorter, and D.R. Southworth. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348):273-279. pdf file link (*Co-first author).

Torrente, M.P., E. Chuang, M.M. Noll, M.E. Jackrel, M.S. Go, and J. Shorter. (2016). Mechanistic insights into Hsp104 potentiation. J. Biol. Chem. 291(10):5101-5115. pdf file link

Millard, J.T., E. Chuang, J.S. Lucas, E.E. Nagy, and G.T. Davis. (2013). Case-Study Investigation of Equine Maternity via PCR-RFLP: A Biochemistry Laboratory Experiment. J Chem Educ. 90(11). doi: 10.1021/ed300740r. pdf file link

 

 

 

 

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Department of Biochemistry & Biophysics
p3
University of Pennsylvania