Edward Gomes was an undergraduate at the University of Pennsylvania and worked in the lab from September 2014 to May 2017. He was a mentor in Harrison College House's FreshEx Program. In 2016, Ed was elected to Phi Beta Kappa. In 2017, Ed graduated with a M.S. in Chemistry and B.A. in Biochemistry. Ed was then a research specialist in the lab from July 2017 to June 2018. In his free time, Ed loves hiking, art, reading manga, and cooking. Ed lives in Brookhaven, PA, a suburb of Philly. Ed went on to pursue his M.D. at the Perelman School of Medicine at the University of Pennsylvania.

Publications

March, Z.M., K. Sweeney°, H. Kim°, X. Yan°, L.M. Castellano, M.E. Jackrel, J. Lin, E. Chuang, E. Gomes, C. W. Willicott, K. Michalska, R. Jedrzejczak, A. Joachimiak, K.A. Caldwell, G.A. Caldwell, O. Shalem, and J. Shorter. (2020). Therapeutic genetic variation revealed in diverse Hsp104 homologs. eLife. 9:e57457. pdf file link (°Co-second author).

Cook, C.N., Y. Wu, H.M. Odeh, T.F. Gendron, K. Jansen-West, G. del Rosso, M. Yue, P. Jiang, E. Gomes, J. Tong, L.M. Daughrity, N.M. Avendano, M. Castanedes-Casey, W. Shao, B. Oskarsson, G.S. Tomassy, A. McCampbell, F. Rigo, D.W. Dickson, J. Shorter, Y-J. Zhang, and L. Petrucelli. (2020). C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy. Sci. Transl. Med. 12(559):eabb3774. pdf file link

Gomes, E. and J. Shorter. (2019). The molecular language of membraneless organelles. J. Biol. Chem. 294(18):7115–7127. pdf file link

Mann, J.R., A.M. Gleixner, J.C. Mauna, E. Gomes, M.R. DeChellis-Marks, P.G. Needham, K.E. Copley, B. Hurtle, B. Portz, N.J. Pyles, L. Guo, C.B. Calder, Z.P. Wills, U.B. Pandey, J.K. Kofler, J.L. Brodsky, A. Thathiah, J. Shorter, and C.J. Donnelly. (2019). RNA binding antagonizes neurotoxic phase transitions of TDP-43. Neuron. 102(2):321-338. pdf file link

McGurk, L.*, E. Gomes*, L. Guo*, J. Shorter, and N.M. Bonini. (2018). Poly(ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation. Biochemistry. 57(51):6923−6926. pdf file link (*Co-first author.).

Vogler, T.O., J.R. Wheeler, E.D. Nguyen, M.P. Hughes, K.A. Britson, E. Lester, B. Rao, N. Dalla Betta, O.N. Whitney, T.E. Ewachiw, E. Gomes, J. Shorter, T.E. Lloyd, D.S. Eisenberg, J.P. Taylor, A.M. Johnson, B.B. Olwin, and R. Parker. (2018). TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 563(7732):508-513. pdf file link

McGurk L., E. Gomes, L. Guo, J. Mojsilovic-Petrovic, V. Tran, R.G. Kalb, J. Shorter, and N.M. Bonini. (2018). Poly(ADP-ribose) prevents aberrant phase separation of TDP-43 by promoting liquid demixing and stress-granule localization. Mol Cell. 71(5):703-717. pdf file link