Hana Odeh was a Post-Doctoral Fellow and Research Associate in the lab. She worked in the lab from November 2018 to June 2026. Hana received her Bachelor’s degree in Biological Sciences from Jordan University in 2008. She then received her Master’s, and PhD degrees in Biochemistry and Molecular Biology from Johns Hopkins School of Public Health in 2012, and in 2018, respectively. Her PhD work focused on characterizing the regulation and function of the SUMO-specific isopeptidase SENP2. In 2018, Hana was awarded an AstraZeneca Post-Doctoral Fellowship. In 2021, Hana won an Alzheimer’s Association Research Fellowship. In 2021, Hana also won the Ruth Keris Award for Departmental and Graduate Group Service. In 2023, Hana became a Johnson Foundation Fellow. Hana has returned to Jordan.

Publications

Copley, K.E., J.C. Mauna, H. Danielson, Q. Chen, B. Ozguney, M. Ngo, L. Xie, A. Smirnov, M. Davis, L. Mayne, M. Linsenmeier, J.D. Rubien, C.A. Bergmann, B. Portz, B.L. Lee, H.M. Odeh, L. Lai, Y-W. Chang, M. Hallegger, J. Ule, P. Pasinelli, Y. Poon, J. Mittal, N.L. Fawzi, B.E. Black, C.J. Donnelly, B.K. Jensen, and J. Shorter. (2026). Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration. Science. 392 (6798):eadv3301. pdf file link

Guo, L.*^, J.R. Mann*, J.C. Mauna°, K.E. Copley°, H. Wang°, J.D. Rubien°, C.A. Bergmann, J.L. Carey, J. Merjane, M. Ngo, J. Xu, H.M. Odeh, J. Lin, B.L. Lee, L. Ganser, E. Robinson, K.M. Kim, A.C. Murthy, T. Paul, B. Portz, A.M. Gleixner, Z. Diaz, A. Smirnov, G. Padilla, E. Lavorando, C. Espy, Y. Shang, E.J. Huang, A. Chesi, N.L. Fawzi, S. Myong, C.J. Donnelly^, and J. Shorter^. (2026). Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. Mol. Cell. 86(1):114-134.e10. pdf file link (*Co-first author. °Co-second author. ^Co-corresponding author).

Aikio, M.*, H.M. Odeh*, H.J. Wobst, B.L. Lee, Ú. Chan, J.C. Mauna, K.L. Mack, B. Class, T.A. Ollerhead, A.F. Ford, E.M. Barbieri, R.R. Cupo, L.E. Drake, J.L. Smalley, Y-T. Lin, S. Lam, R. Thomas, N. Castello, A. Baral, J.N. Beyer, M.A. Najar, J. Dunlop, A.D. Gitler, A. Javaherian, J.A. Kaye, G.M. Burslem, D.G. Brown, S. Finkbeiner, S.J. Moss, N.J. Brandon, and J. Shorter. (2025). Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy. Cell Rep. 44(1):115205. pdf file link (*Co-first author.).

Balendra, R., I. Ruiz de los Mozos, H.M. Odeh, I. Glaria, C. Milioto, K.M. Wilson, A.M. Ule, M. Hallegger, L. Masino, S. Martin, R. Patani, J. Shorter, J. Ule, and A.M. Isaacs. (2022). Genome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides. Life Sci. Alliance. 6(9):e202201824. pdf file link

Rhine, K., H.M. Odeh, J. Shorter, and S. Myong. (2023). Regulation of biomolecular condensates by poly(ADP-ribose). Chem. Rev. 123(14):9065-9093. pdf file link

Odeh, H.M., and J. Shorter. (2022). Aggregates of TDP-43 protein spiral into view. Nature. 601(7891):29-30. pdf file link

Odeh, H.M.*, C.M. Fare*, and J. Shorter. (2022). Nuclear-import receptors counter deleterious phase transitions in neurodegenerative disease. J. Mol. Biol. 434(1):167220. pdf file link cover (*Co-first author).

Hallegger, M.*, A.M. Chakrabarti*, F.C.Y. Lee*, B.L. Lee, A.G. Amalietti, H.M. Odeh, K.E. Copley, J.D. Rubien, B. Portz, K. Kuret, I. Huppertz, F. Rau, R. Patani, N.L. Fawzi, J. Shorter, N.M. Luscombe, and J. Ule. (2021). TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 184(18):4680-4696.e22. pdf file link (*Co-first author).

Hutten, S., S. Usluer, B. Bourgeois, F. Simonetti, H.M. Odeh, C.M. Fare, M. Czuppa, M. Hruska-Plochan, M. Hofweber, M. Polymenidou, J. Shorter, D. Edbauer, T. Madl, and D. Dormann. (2020). Nuclear import receptors directly bind to arginine-rich dipeptide repeat proteins and suppress their pathological interactions. Cell Rep. 33(12):108538. pdf file link

Cook, C.N.*, Y. Wu*, H.M. Odeh*, T.F. Gendron, K. Jansen-West, G. del Rosso, M. Yue, P. Jiang, E. Gomes, J. Tong, L.M. Daughrity, N.M. Avendano, M. Castanedes-Casey, W. Shao, B. Oskarsson, G.S. Tomassy, A. McCampbell, F. Rigo, D.W. Dickson, J. Shorter, Y-J. Zhang, and L. Petrucelli. (2020). C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy. Sci. Transl. Med. 12(559):eabb3774. pdf file link (*co-first author).

Odeh, H.M., and J. Shorter^. (2020). Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTD. Emerg. Top. Life Sci. 4(3):293–305. pdf file link cover

Odeh, H.M., and J. Shorter. (2020). The sense of targeting nonsense-mediated decay in C9-ALS/FTD. Neuron. 106(1):6-9. pdf file link (^Corresponding author).

Odeh, H. M., E. Coyaud, B. Raught, and M.J. Matunis. (2018). The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-terminal amphipathic α-helix. Mol. Biol. Cell. 29(15):1878-1890. pdf file link

Odeh, H. M., C. Kleinguetl, R. Ge, B.R. Zirkin, and H. Chen. (2014). Regulation of the proliferation and differentiation of leydig stem cells in the adult testis. Biol. Reprod. 90(6):123. pdf file link

Gleason, J. E., C.X. Li, H.M. Odeh, and V.C. Culotta. (2013). Species-specific activation of Cu/Zn SOD by its CCS copper chaperone in the pathogenic yeast Candida albicans. J. Biol. Inorg. Chem. 19(4- 5):595-603. pdf file link

Al-Aboudi, A., H. Odeh, A. Khalid, Q. Naz, and M.I. Choudhary. (2009). Butyrylcholinesterase inhibitory activity of testosterone and some of its metabolites. J. Enzyme Inhib. Med. Chem. 24(2), 553-558. pdf file link