Hana Odeh is a Johnson Foundation Fellow in the lab. She received her Bachelor’s degree in Biological Sciences from Jordan University in 2008. She then received her Master’s, and PhD degrees in Biochemistry and Molecular Biology from Johns Hopkins School of Public Health in 2012, and in 2018, respectively. Her PhD work focused on characterizing the regulation and function of the SUMO-specific isopeptidase SENP2. In 2018, Hana was awarded an AstraZeneca Post-Doctoral Fellowship. In 2021, Hana won an Alzheimer’s Association Research Fellowship. In 2021, Hana also won the Ruth Keris Award for Departmental and Graduate Group Service. In 2023, Hana became a Johnson Foundation Fellow.
Publications
Aikio, M.*, H.M. Odeh*, H.J. Wobst, B.L. Lee, Ú. Chan, J.C. Mauna, K.L. Mack, B. Class, T.A. Ollerhead, A.F. Ford, E.M. Barbieri, R.R. Cupo, L.E. Drake, J.L. Smalley, Y-T. Lin, S. Lam, R. Thomas, N. Castello, A. Baral, J.N. Beyer, M.A. Najar, J. Dunlop, A.D. Gitler, A. Javaherian, J.A. Kaye, G.M. Burslem, D.G. Brown, S. Finkbeiner, S.J. Moss, N.J. Brandon, and J. Shorter. (2025). Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy. Cell Rep. 44(1):115205. pdf file link (*Co-first author.).
Copley, K.E., J.C. Mauna, H. Danielson, M. Ngo, L. Xie, A. Smirnov, M. Davis, L. Mayne, M. Linsenmeier, J.D. Rubien, B. Portz, B.L. Lee, H.M. Odeh, M. Hallegger, J. Ule, P. Pasinelli, Y. Poon, N.L. Fawzi, B.E. Black, C.J. Donnelly, B.K. Jensen, and J. Shorter. Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration. bioRxiv. doi: 10.1101/2024.12.14.628507. pdf file link
Guo, L.*^, J.R. Mann*, J.C. Mauna°, K.E. Copley°, H. Wang°, J.D. Rubien°, H.M. Odeh, J. Lin, B.L. Lee, L. Ganser, E. Robinson, K.M. Kim, A.C. Murthy, T. Paul, B. Portz, A.M. Gleixner, Z. Diaz, J.L. Carey, A. Smirnov, G. Padilla, E. Lavorando, C. Espy, Y. Shang, E.J. Huang, A. Chesi, N.L. Fawzi, S. Myong, C.J. Donnelly^, and J. Shorter^. (2023). Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. bioRxiv. doi:10.1101/2023.09.04.555754. pdf file link (*Co-first author. °Co-second author. ^Co-corresponding author).
Balendra, R., I. Ruiz de los Mozos, H.M. Odeh, I. Glaria, C. Milioto, K.M. Wilson, A.M. Ule, M. Hallegger, L. Masino, S. Martin, R. Patani, J. Shorter, J. Ule, and A.M. Isaacs. (2022). Genome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides. Life Sci. Alliance. 6(9):e202201824. pdf file link
Rhine, K., H.M. Odeh, J. Shorter, and S. Myong. (2023). Regulation of biomolecular condensates by poly(ADP-ribose). Chem. Rev. 123(14):9065-9093. pdf file link
Odeh, H.M., and J. Shorter. (2022). Aggregates of TDP-43 protein spiral into view. Nature. 601(7891):29-30. pdf file link
Odeh, H.M.*, C.M. Fare*, and J. Shorter. (2022). Nuclear-import receptors counter deleterious phase transitions in neurodegenerative disease. J. Mol. Biol. 434(1):167220. pdf file link cover (*Co-first author).
Hallegger, M.*, A.M. Chakrabarti*, F.C.Y. Lee*, B.L. Lee, A.G. Amalietti, H.M. Odeh, K.E. Copley, J.D. Rubien, B. Portz, K. Kuret, I. Huppertz, F. Rau, R. Patani, N.L. Fawzi, J. Shorter, N.M. Luscombe, and J. Ule. (2021). TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 184(18):4680-4696.e22. pdf file link (*Co-first author).
Hutten, S., S. Usluer, B. Bourgeois, F. Simonetti, H.M. Odeh, C.M. Fare, M. Czuppa, M. Hruska-Plochan, M. Hofweber, M. Polymenidou, J. Shorter, D. Edbauer, T. Madl, and D. Dormann. (2020). Nuclear import receptors directly bind to arginine-rich dipeptide repeat proteins and suppress their pathological interactions. Cell Rep. 33(12):108538. pdf file link
Cook, C.N.*, Y. Wu*, H.M. Odeh*, T.F. Gendron, K. Jansen-West, G. del Rosso, M. Yue, P. Jiang, E. Gomes, J. Tong, L.M. Daughrity, N.M. Avendano, M. Castanedes-Casey, W. Shao, B. Oskarsson, G.S. Tomassy, A. McCampbell, F. Rigo, D.W. Dickson, J. Shorter, Y-J. Zhang, and L. Petrucelli. (2020). C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy. Sci. Transl. Med. 12(559):eabb3774. pdf file link (*co-first author).
Odeh, H.M., and J. Shorter^. (2020). Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTD. Emerg. Top. Life Sci. 4(3):293–305. pdf file link cover
Odeh, H.M., and J. Shorter. (2020). The sense of targeting nonsense-mediated decay in C9-ALS/FTD. Neuron. 106(1):6-9. pdf file link (^Corresponding author).
Odeh, H. M., Coyaud, E., Raught, B., and Matunis, M.J. (2018). The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-terminal amphipathic α-helix. Molecular Biology of the Cell. 29(15):1878-1890. pdf file link
Odeh, H. M., Kleinguetl, C., Ge, R., Zirkin B. R., and Chen, H. (2014). Regulation of the proliferation and differentiation of leydig stem cells in the adult testis. Biology of Reproduction. 90(6):123. pdf file link
Gleason, J. E., Li, C. X., Odeh, H. M., and Culotta, V. C. (2013). Species-specific activation of Cu/Zn SOD by its CCS copper chaperone in the pathogenic yeast Candida albicans. Journal of Biological Inorganic Chemistry: JBIC: A Publication of the Society of Biological Inorganic Chemistry. 19(4- 5):595-603. pdf file link
Al-Aboudi, A., Odeh, H., Khalid, A., Naz, Q., and Choudhary, M. I. (2009). Butyrylcholinesterase inhibitory activity of testosterone and some of its metabolites. Journal of Enzyme Inhibition and Medicinal Chemistry. 24(2), 553-558. pdf file link
