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Korrie was a graduate student in the Biochemistry and Molecular Biophysics Graduate Group. She graduated from Syracuse University in 2013 with a B.S. in Biochemistry and a minor in Psychology. Korrie enjoys playing soccer, running, and is a dedicated New York Rangers fan. She grew up in Utica, New York, and is excited to explore Philadelphia! In 2013, Korrie won a National Science Foundation Graduate Research Fellowship and a BMB Raiziss Award. In 2016 and 2017, Korrie won an ADDF Young Investigator Scholarship. In 2018, Korrie was selected and participated in the 68th Lindau Nobel Laureate Meeting. Korrie defended her Ph.D. thesis 'Engineering protein disaggregases to counter alpha-synuclein and amyloid-beta neurotoxicity' in June, 2019. Korrie went on to pursue a post-doc at Merck.

Publications

Aikio, M., H.J. Wobst, H.M. Odeh, B.L. Lee, B. Class, T.A. Ollerhead, K.L. Mack, A.F. Ford, E.M. Barbieri, R.R. Cupo, L.E. Drake, N. Castello, A. Baral, J. Dunlop, A.D. Gitler, A. Javaherian, S. Finkbeiner, D.G. Brown, S.J. Moss, N.J. Brandon, and J. Shorter. (2021). Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy. BioRxiv. doi:pdf file link

Zhu, G.*, D.S. Harischandra*, S. Ghaisas, P. Zhang, W. Prall, L. Huang, C. Maghames, L. Guo, E. Luna, K.L. Mack, M.P. Torrente, K.C. Luk, J. Shorter, and X. Yang. (2020). TRIM11 prevents and reverses protein aggregation and rescues a mouse model of Parkinson’s disease. Cell Rep. 33(9):108418. pdf file link (*Co-first author).

Mack, K.L.*, H. Kim*, M.E. Jackrel, J. Lin, J.E. DeNizio, X. Yan, E. Chuang, A. Tariq, R.R. Cupo, L.M. Castellano, K.A. Caldwell, G.A. Caldwell, and J. Shorter. (2020). Tuning Hsp104 specificity to selectively detoxify α-synuclein. BioRxiv. doi: 10.1101/2020.04.15.043935. pdf file link (*Co-first author.).

Wobst, H.J., K.L. Mack, D.G. Brown, N.J. Brandon, and J. Shorter. (2020). The clinical trial landscape in amyotrophic lateral sclerosis – past, present and future. Med. Res. Rev. doi:10.1002/med.21661 pdf file link (^Co-corresponding author).

Tariq, A.*, J. Lin*, M.E. Jackrel*, C.D. Hesketh, P.J. Carman, K.L. Mack, R. Weitzman, C. Gambogi, O.A. Hernandez Murillo, E.A. Sweeny, E. Gurpinar, A.L. Yokom, S.N. Gates, K. Yee, S. Sudesh, J. Stillman, A.N. Rizo, D.R. Southworth, and J. Shorter. (2019). Mining disaggregase sequence space to safely counter TDP-43, FUS, and alpha-synuclein proteotoxicity. Cell Rep. 28(8):2080–2095. pdf file link (*Co-first author).

Durie, C.L., J. Lin, N.W. Scull, K.L. Mack, M.E. Jackrel, E.A. Sweeny, L.M. Castellano, J. Shorter, and A.L. Lucius. (2019). Hsp104 and potentiated variants can operate as distinct non-processive translocases. Biophys. J. 116(10):1856-1872. pdf file link

March, Z.M.*, K.L. Mack*, and J. Shorter. (2019). AAA+ protein-based technologies to counter neurodegenerative disease. Biophys. J. 116(8):1380-1385. pdf file link (*Co-first author).

Tariq, A.*, J. Lin*, M.M. Noll*, M.P. Torrente, K.L. Mack, O. Hernandez Murillo, M.E. Jackrel, and J. Shorter. (2018). Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain. FEMS Yeast Res. doi: 10.1093/femsyr/foy042. pdf file link (*Co-first author).

Gates, S.N*., A.L. Yokom*, J. Lin, M.E. Jackrel, A.N. Rizo, N.M. Kendsersky, C.E. Buell, E.A. Sweeny, K.L. Mack, E. Chuang, M.P. Torrente, M. Su, J. Shorter, and D.R. Southworth. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348):273-279. pdf file link (*Co-first author).

Weaver, C.L., E.C. Duran, K.L. Mack, J. Lin, M.E. Jackrel, E.A. Sweeny, J. Shorter, and A.L. Lucius. (2017). Avidity for polypeptide binding by nucleotide-bound Hsp104 structures. Biochemistry. 56(15):2071–2075. pdf file link

Yokom, A.L., S.N. Gates, M.E. Jackrel, K.L. Mack, M. Su, J. Shorter, and D.R. Southworth. (2016). Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nat. Struct. Mol. Biol.23(9):830-7. pdf file link

Mack, K.L., and J. Shorter. (2016). Engineering and evolution of molecular chaperones and protein disaggregases with enhanced activity. Front. Mol. Biosci. 3:8. pdf file link

Moroz, Y.S., T.T. Dunston, O.V. Makhlynets, O.V. Moroz, Y. Wu, J.H. Yoon, A.B. Olsen, J.M. McLaughlin, K.L. Mack, P.M. Gosavi, N.A.J. van Nuland, and I.V. Korendovych. (2015). New Tricks for Old Proteins: Single Mutations in a Nonenzymatic Protein Give Rise to Various Enzymatic Activities. J. Am. Chem. Soc., 137(47):14905–14911. pdf file link

Raymond, E.A., K.L. Mack, J.H. Yoon, O.V. Moroz, Y.S. Moroz, and I.V. Korendovych. (2015). Design of an allosterically regulated retroaldolase. Protein Sci. 24(4):561-70. pdf file link

Mack, K.L., O.V. Moroz, Y.S. Moroz, A.B. Olsen, J.M. McLaughlin,  and I.V. Korendovych. (2013). Reprogramming EF-hands for design of catalytically amplified lanthanide sensors. J. Biol. Inorg. Chem. 18(4): 411-18. pdf file link

Moroz, O.V., Y.S. Moroz, Y. Wu, A.B. Olsen, H. Cheng, K.L. Mack, J.M. McLaughlin, E.A. Raymond, K. Zhezherya, H. Roder, and I.V. Korendovych. (2013). A Single Mutation in a Regulatory Protein Produces Evolvable Allosterically Regulated Catalyst of Unnatural Reaction. Angew. Chemie. Int. Ed. 52(24): 6246-9. pdf file link

 

 

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Department of Biochemistry & Biophysics
p3
University of Pennsylvania