- Lab Members
In the lab I explore the RNA binding protein hnRNPK, and its role and interactions in glucolipotoxic conditions within the beta cell. I am a mother to 5 kids and in our free time we love to travel and spend time in nature.
In the lab, I study the molecular mechanism of metabolic stress response and glutamine metabolism in beta cells, with a special focus on mitochondrial transaminase "GPT2". In my free time, I enjoy spending time with my cats, cooking, and exploring hiking trails around Philly.
My projects focus on the roles of PDX1 and its interacting proteins in pancreas development by using both in vivo and in vitro model systems.
I’m a graduate student in the Stoffers lab in the Genetic and Epigenetics group. I like exploring Philly as the honorary Stoffers Lab Yelp, reading, and watching too much reality television. My work focuses on understanding the role of the E3 ubiquitin ligase adaptor protein, SPOP, in the mature pancreatic beta cell. SPOP is a known post-translational regulator to the important beta cell transcription factor, PDX1, and our work suggests that SPOP is necessary for normal beta cell function.
Matt is a PhD student in the Cell and Molecular biology program in the genetics and epigenetics subtrack. He is fascinated by post-transcriptional regulation and has undertaken navigating the laboratory into an exciting new direction looking at the in vivo influence of PCBP RNA binding proteins on beta cell survival and function. Outside of lab, Matt enjoys experiencing the fine cuisine that Philly has to offer and spending time with friends and family.
In the lab I investigate the role of the RNA binding protein, PCBP1, and am characterizing its function within the beta-cell. During my free time I love to spend time outdoors with my dogs, rock climb, travel, and practice mindfulness.