Jonathan P. Katz, M.D.
Assistant Professor of Medicine
Attending Physician, Gastroenterology Division
Attending Physician, Gastroenterology Division
Attending Physician, Gastroenterology Division
Director, Undergraduate Student Scholars Program, Gastroenterology Division
Member, Health Professions Advisory Board
Ad Hoc Reviewer, Pilot Projects
Associate Director, Gastroenterology Fellowship Training Program
Director, Morphology Core, NIH Center for Molecular Studies in Digestive and Liver Diseases
Department: Medicine
Graduate Group Affiliations
Contact information
600 Clinical Research Building
415 Curie Blvd.
Philadelphia, PA 19104-6140
415 Curie Blvd.
Philadelphia, PA 19104-6140
Office: 215-746-7780
Fax: 215-573-2024
Fax: 215-573-2024
Email:
jpkatz@mail.med.upenn.edu
jpkatz@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Gastroenterology Division: Faculty Page
Center for Molecular Studies in Digestive and Liver Diseases
CAMB Faculty Page
Search PubMed for articles
Gastroenterology Division: Faculty Page
Center for Molecular Studies in Digestive and Liver Diseases
CAMB Faculty Page
Education
A.B. (Chemistry)
Columbia University, Columbia College , 1988.
M.D.
University of Chicago, Pritzker School of Medicine, 1993.
A.B. (Chemistry)
Columbia University, Columbia College , 1988.
M.D.
University of Chicago, Pritzker School of Medicine, 1993.
Post-Graduate Training
Fellowship, Gastroenterology , Hospital of the University of Pennsylvania, 1995-1999.
Internship, Internal Medicine , Hospital of the University of Pennsylvania, 1993-1994.
Residency, Internal Medicine , Hospital of the University of Pennsylvania, 1994-1995.
Fellowship, Gastroenterology , Hospital of the University of Pennsylvania, 1995-1999.
Internship, Internal Medicine , Hospital of the University of Pennsylvania, 1993-1994.
Residency, Internal Medicine , Hospital of the University of Pennsylvania, 1994-1995.
Certifications
American Board of Internal Medicine, Gastroenterology, 1998.
Permanent linkAmerican Board of Internal Medicine, Gastroenterology, 1998.
Description of Research Expertise
Research InterestsFunctional analysis of gastrointestinal development, proliferation, and differentiation.
Key words: Klf4, Klf5, esophagus, intestine, gastrointestinal, epithelia, proliferation, differentiation.
Description of Research
My research focuses on the functional analysis of gastrointestinal development, proliferation, and differentiation. Recently, my laboratory has concentrated on Klf4 and Klf5, two related Krüppel-like factor (KLF) family members expressed in the gastrointestinal epithelia. Klf4 and Klf5 are important regulators of cellular proliferation and differentiation both in vitro and in vivo. Expression patterns and biochemical evidence suggest that Klf4 and Klf5 have complementary roles in regulating gastrointestinal morphogenesis, proliferation, and differentiation, by binding to identical cis-regulatory elements. While Klf4 negatively regulates proliferation and promotes cellular differentiation, Klf5 has been implicated as a positive regulator of cell proliferation with transforming properties in vitro.
Using tissue-specific gene ablation and transgenic approaches, we have generated a number of mouse models to investigate the function of Klf4 and Klf5 in development and gastrointestinal epithelial homeostasis in vivo. These mouse models are complemented by novel in vitro model systems, using primary esophageal cells in two-dimensional culture and three-dimensional organotypic culture. These experiments allow us to dissect the molecular mechanisms regulating gastrointestinal epithelial homeostasis, including the role of epithelial-mesenchymal interactions. Using these new in vitro and in vivo models, we are examining the specific factors which control the balance between proliferation and differentiation in gastrointestinal epithelia and the elements which disrupt this balance during mucosal injury and carcinogenesis
Selected Publications
Tetreault MP, Goldstein BG, Yang Y, Yu QC, Rustgi AK, Katz JP: The zinc finger transcription factor Klf4 controls esophageal epithelial differentiation and cytoskeletal organization in vivo. December 2007 Notes: Accepted for presentation at the American Scoiety for Cell Biology Annual Meeting, Washington, DC.Alrefai WA, Wen X, Jiang W, Katz JP, Steinbrecher KA, Cohen MB, Williams IR, Dudeja PK, Wu GD : Molecular cloning and promoter analysis of Down-Regulated in Adenoma (DRA). Am J Physiol Gastrointest Liver Physiol 293(5): G923-34, Nov 2007.
Klaewsongkram, Jettanong. Yang, Yinhua. Golech, Susanne. Katz, Jonathan. Kaestner, Klaus H. Weng, Nan-Ping.: Kruppel-like factor 4 regulates B cell number and activation-induced B cell proliferation. Journal of Immunology 179(7): 4679-84, Oct 1 2007.
Feinberg, Mark W. Wara, Akm Khyrul. Cao, Zhuoxiao. Lebedeva, Maria A. Rosenbauer, Frank. Iwasaki, Hiromi. Hirai, Hideyo. Katz, Jonathan P. Haspel, Richard L. Gray, Susan. Akashi, Koichi. Segre, Julie. Kaestner, Klaus H. Tenen, Daniel G. Jain, Mukesh K.: The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO Journal 26(18): 4138-48, Sep 19 2007.
Ghaleb, Amr M. McConnell, Beth B. Nandan, Mandayam O. Katz, Jonathan P. Kaestner, Klaus H. Yang, Vincent W.: Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Research 67(15): 7147-54, Aug 1 2007.
Tetreault MP, Goldstein BG, Katz JP: Loss of Klf4 perturbs esophageal epithelial homeostasis. July 2007 Notes: Presented at the Gordon Research Conference, Smithfield, RI.
Ghaleb AM, McConnell BB, Nandan MO, Katz JP, Kaestner KH, Yang VW : Role of Krüppel-like factor 4 in Wnt and notch signaling in the intestinal tract. May 2007 Notes: Presented at the Digestive Disease Week, Washington, DC.
Zhang H, Rusovici R, Bialkowska A, Chanchevalap S, Katz JP, Shim H, Yang VW, Yun C: Induction of Krüppel-like factor 5 expression by lysophosphatidic acids. May 2007 Notes: Presented at the Digestive Disease Week, Washington, DC.
Yang Y, Yermolina Y, Goldstein BG, Katz JP: Klf5 promotes cell migration in esophageal keratinocytes by activating the integrin linked kinase pathway. May 2007 Notes: Presented at the Digestive Disease Week, Washington, DC.
Goldstein BG, Chao H, Yang Y, Yermolina Y, Tobia JW, Katz JP: Overexpression of Krüppel-like factor 5 in esophageal epithelia in vivo leads to increased proliferation in basal but not suprabasal cells. Am J Physiol Gastrointest Liver Physiol 292: G1784-92, 2007.
