Hao Shen, Ph.D.

faculty photo
Associate Professor of Microbiology
Department: Microbiology
Graduate Group Affiliations

Contact information
303D Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 573-5259
Fax: (215) 573-9068
Lab: 215-898-6586
Education:
B.S.
Jiangxi University, China, 1983.
Ph.D.
University of California at Riverside, 1992.
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Description of Research Expertise

Research Interests
Immunity against intracellular, emerging and co-infecting agents.

Key words: T cell responses and memory, bacterial pathogenesis, vaccine.

Description of Research
We have a long-standing interest in basic questions related to generation of effective immune responses, mechanisms of protective immunity, and the establishment of long-term immunological memory. For these basic studies, we have used two well-characterized murine models of infection with lymphocytic choriomeningitis virus (LCMV) and Listeria monocytogenes. More recently, we have become interested in viral/bacterial co-infections, which occur frequently in clinics and often result in more severe disease than infection by an individual pathogen. A striking example of this is the high mortality caused by secondary bacterial pneumonia following flu infection. We are: 1) studying how inflammation induced by a bacterial pathogen may affect the host response to a co-infecting viral pathogen and vice versa, 2) investigating the mechanisms of bacterial pathogenesis that contribute to lethal secondary bacterial pneumonia following flu infection, 3) identifying immune mechanisms and protective antigens that provide immunity against co-infection, and 4) examining how these protective mechanisms may be inhibited during co-infection that leads to high mortality and inadequate immunological memory. Through these studies, we have gained new insights into complexity of tripartite interactions between the virus, bacterium and host immune system. Based on our new findings, we are developing novel, combinational vaccine approaches tailored towards co-infection.

Selected Publications

Penaloza-MacMaster Pablo, Barber Daniel L, Wherry E John, Provine Nicholas M, Teigler Jeffrey E, Parenteau Lily, Blackmore Stephen, Borducchi Erica N, Larocca Rafael A, Yates Kathleen B, Shen Hao, Haining W Nicholas, Sommerstein Rami, Pinschewer Daniel D, Ahmed Rafi, Barouch Dan H: Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection. Science (New York, N.Y.) 347(6219): 278-82, Jan 2015.

Zhu Kai, Yang Juhao, Luo Kaiming, Yang Chunhui, Zhang Na, Xu Ruifeng, Chen Jianxia, Jin Mingfei, Xu Bin, Guo Nining, Wang Jianrong, Chen Zuolong, Cui Ying, Zhao Hui, Wang Yan, Deng Chaoyang, Bai Li, Ge Baoxue, Qin Cheng-Feng, Shen Hao, Yang Chun-Fu, Leng Qibin: TLR3 signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71 infection. PLoS pathogens 11(1): e1004613, Jan 2015.

Zhang Fuqin, Zhou Xiaohui, DiSpirito Joanna R, Wang Chuan, Wang Ying, Shen Hao: Epigenetic manipulation restores functions of defective CD8⁺ T cells from chronic viral infection. Molecular therapy : the journal of the American Society of Gene Therapy 22(9): 1698-706, Sep 2014.

Jiang Jiu, Fisher Erin M, Hensley Scott E, Lustigman Sara, Murasko Donna M, Shen Hao: Antigen sparing and enhanced protection using a novel rOv-ASP-1 adjuvant in aqueous formulation with influenza vaccines. Vaccine 32(23): 2696-702, May 2014.

Zeng Weihong, Wang Ying, Liu Zhicui, Khanniche Asma, Hu Qingliang, Feng Yan, Ye Weiyi, Yang Jianglong, Wang Shujun, Zhou Lin, Shen Hao, Wang Yan: Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice. Cellular & molecular immunology 11(4): 367-76, Jul 2014.

Stelekati Erietta, Shin Haina, Doering Travis A, Dolfi Douglas V, Ziegler Carly G, Beiting Daniel P, Dawson Lucas, Liboon Jennifer, Wolski David, Ali Mohammed-Alkhatim A, Katsikis Peter D, Shen Hao, Roos David S, Haining W Nicholas, Lauer Georg M, Wherry E John: Bystander chronic infection negatively impacts development of CD8(+) T cell memory. Immunity 40(5): 801-13, May 2014.

Wolf Amaya I, Strauman Maura C, Mozdzanowska Krystyna, Williams Katie L, Osborne Lisa C, Shen Hao, Liu Qin, Garlick David, Artis David, Hensley Scott E, Caton Andrew J, Weiser Jeffrey N, Erikson Jan: Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease. Virology 462-463: 254-65, Aug 2014.

O'Brien Shaun, Thomas Rajan M, Wertheim Gerald B, Zhang Fuqin, Shen Hao, Wells Andrew D: Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production. Journal of immunology (Baltimore, Md. : 1950) 192(11): 5118-29, Jun 2014.

Wong Sandy M, Bernui Mariana, Shen Hao, Akerley Brian J: Genome-wide fitness profiling reveals adaptations required by Haemophilus in coinfection with influenza A virus in the murine lung. Proceedings of the National Academy of Sciences of the United States of America 110(38): 15413-8, Sep 2013.

Han Daehee, Walsh Matthew C, Cejas Pedro J, Dang Nicholas N, Kim Youngmi F, Kim Jihyun, Charrier-Hisamuddin Laetitia, Chau Lillian, Zhang Qin, Bittinger Kyle, Bushman Frederic D, Turka Laurence A, Shen Hao, Reizis Boris, Defranco Anthony L, Wu Gary D, Choi Yongwon: Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity 38(6): 1211-22, Jun 2013.

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Last updated: 05/14/2015
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