Claire H. Mitchell, Ph.D.
Associate Professor of Anatomy & Cell Biology
Department: Anatomy & Cell Biology
Graduate Group Affiliations
Contact information
440 Levy Bldg
240 S. 40th St
Philadelphia, PA 19104
240 S. 40th St
Philadelphia, PA 19104
Office: (215) 573-2176
Email:
CHM@UPENN.EDU
CHM@UPENN.EDU
Publications
Education:
B.Sc. (Neurobiology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Ion Channels of Ocular Epithelia)
Institute of Ophthalmology, University College London, U.K., 1994.
Permanent linkB.Sc. (Neurobiology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Ion Channels of Ocular Epithelia)
Institute of Ophthalmology, University College London, U.K., 1994.
Description of Research Expertise
My research is concerned with the basic physiological mechanisms that interfere with the survival of neurons, astrocytes and epithelial cells as we age.Selected Publications
Li, A., Leung, C. T., Peterson-Yantorno, K., Stamer, W. D., Mitchell, C. H., Civan, M. M.: Mechanisms of ATP release by human trabecular meshwork cells, the enabling step in purinergic regulation of aqueous humor outflow. Journal of Cell Physiology doi: 10.1002/jcp.22715., 2011.Zhang M, Hu H-L, Zhang X, Lu W, Lim J, Eysteinsson T, Jacobson KA, Laties AM, Mitchell CH: A3 adenosine receptor blocks effects of NMDA receptor on rat retinal ganglion cells. Neurochemistry Inernationational 56: 35-41, 2010.
Hu, H., Lu, W., Zhang, M., Zhang, X., Argall, A. J., Patel, S., Lee, G. E., Kim, Y. C., Jacobson, K. A., Laties, A. M., Mitchell, C. H.: Stimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo. Experimental Eye Research 91(3): 425-32, 2010.
Li, A., Leung, C. T., Peterson-Yantorno, K., Mitchell, C. H., Civan, M. M.: Pathways for ATP release by bovine ciliary epithelial cells, the initial step in purinergic regulation of aqueous humor inflow. Am J Physiol Cell Physiol 299(6): C1308-17, 2010.
Zeiger, U., Mitchell, C. H., Khurana, T. S.: Superior calcium homeostasis of extraocular muscles. Experimental Eye Research 91(5): 613-22, 2010.
Liu J, Lu W, Reigada D, Nguyen J, Laties AM, Mitchell, CH: Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: Pharmacologic approaches and functional recovery. Investigative Ophthalmology & Visual Science 49(2): 772-780, 2008.
Reigada D, Lu W, Zhang M, Mitchell CH : Elevated pressure triggers a physiological release of ATP from the retina: possible role for pannexin hemichannels Neuroscience 157: 396-404, 2008.
Mitchell, C.H.: P2X7 receptor kills retinal ganglion cells with glutamate release and excitotoxic NMDA receptor activation. Purinergic Signalling 2: Supp 1, 2008.
Zhang X, Li A, Ge J, Reigada D, Laties AM, Mitchell CH: Acute increase of intraocular pressure releases ATP into the anterior chamber. Experimental Eye Research 85(5): 637-643, 2007.
Lu W, Reigada D, Sevigny J, Mitchell CH: Stimulation of the P2Y(1) receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. Journal of Pharmacology and Experimental Therapeutics 323(1): 157-164, 2007.