Claire H. Mitchell, Ph.D.

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Professor of Anatomy & Cell Biology
Department: Anatomy & Cell Biology

Contact information
440 Levy Bldg
240 S. 40th St
Philadelphia, PA 19104
Office: (215) 573-2176
Lab: chm@upenn.edu
B.Sc. (Biology)
McGill University, Montreal, Canada, 1986.
Ph.D. (Single Ion Channels )
Institute of Ophthalmology, University College London, U.K., 1994.
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Description of Research Expertise

My research is concerned with the basic physiological mechanisms that interfere with the survival of neurons, astrocytes and epithelial cells as we age.

Selected Publications

Campagno, K.E., Mitchell, C.H.: The P2X7 receptor in microglial cells modulates the endolysosomal axis, autophagy and phagocytosis. Frontiers in Cellular Neuroscience 15: 61, 2021.

A. H. Jassim, D. M. Inman and C. H. Mitchell : Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration Frontiers in Pharmacology 12: 699623, 2021.

Campagno KE, Lu W, Jassim AH, Albalawi F, Cenaj A, Tso HY, Clark SP, Sripinun P, Gómez NM, Mitchell CH.: Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure J Neuroinflammation 18: 217, 2021.

H. Guan, M. Nuth, V. Lee, C. Lin, C. H. Mitchell, W. Lu, R.W. Scott, M.H. Parker, J.L Kulp, A.B. Reitz R.P. Ricciardi : Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis Ocular Surface 19: 313-321, 2021.

J. Klionsky, A. K. Abdel-Aziz,.... CH Mitchell, et al.: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy Page: 1-382, 2021.

Shao, X.; Guha, S.; Lu, W.; Campagno, K.E.; Beckel, J.M.; Mills, J.A.; Yang, W.; Mitchell, C.H., : Polarized cytokine release triggered by P2X7 receptor from retinal pigmented epithelial cells dependent on calcium influx. Cells 9: 2537, 2020.

Hersh, E.V.; Moore, P.A.; Grosser, T.; Polomano, R.C.; Farrar, J.T.; Saraghi, M.; Juska, S.A.; Mitchell, C.H.; Theken, K.N., J Dent Res 2020, 99 (7), 777-786: Nonsteroidal anti-inflammatory drugs and opioids in postsurgical dental pain. J Dent Res 99: 777-786, 2020.

Lally, E.T.; Boesze-Battaglia, K.; Dhingra, A.; Gomez, N.M.; Lora, J.; Mitchell, C.H.; Giannakakis, A.; Fahim, S.A.; Benz, R.; Balashova, N., : Aggregatibacter actinomycetemcomitans LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes. Pathogens 9: 74, 2020.

Guan, H.; Nuth, M.; Lee, V.; Lin, C.; Mitchell, C.H.; Lu, W.; Scott, R.W.; Parker, M.H.; Kulp, J.L., 3rd; Reitz, A.B.; Ricciardi, R.P.: Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis. Ocular Surface 19: 313-321, 2020.

Rossi, H.L.; See, L.P.; Foster, W.; Pitake, S.; Gibbs, J.; Schmidt, B.; Mitchell, C.H.; Abdus-Saboor, I.,: Evoked and spontaneous pain assessment during tooth pulp injury. Sci Rep 10: 2759, 2020.

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Last updated: 09/19/2022
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