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  • Claire H. Mitchell
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Faculty

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Claire H. Mitchell, Ph.D.

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Professor of Anatomy & Cell Biology
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Department: Anatomy & Cell Biology
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1f Graduate Group Affiliations 8 a
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46 Contact information
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440 Levy Bldg
31 240 S. 40th St
Philadelphia, PA 19104
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30 Office: (215) 573-2176
3f Lab: chm@upenn.edu
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Email: CHM@UPENN.EDU
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18 Publications
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13 Education:
21 a B.Sc. 14 (Biology) c
3c McGill University, Montreal, Canada, 1986.
 21 a Ph.D. 21 (Single Ion Channels ) c
54 Institute of Ophthalmology, University College London, U.K., 1994.
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Links
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Description of Research Expertise

a8 My research is concerned with the basic physiological mechanisms that interfere with the survival of neurons, astrocytes and epithelial cells as we age.
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Selected Publications

150 Campagno KE, Lu W, Jassim AH, Albalawi F, Cenaj A, Tso HY, Clark SP, Sripinun P, Gómez NM, Mitchell CH.: Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure 2 2 2 3c J Neuroinflammation 18: 217, 2021.

 fe Campagno, K.E., Mitchell, C.H.: The P2X7 receptor in microglial cells modulates the endolysosomal axis, autophagy and phagocytosis. Frontiers in Cellular Neuroscience 15: 61, 2021.

 a1 H. Guan, M. Nuth, V. Lee, C. Lin, C. H. Mitchell, W. Lu, R.W. Scott, M.H. Parker, J.L Kulp, A.B. Reitz R.P. Ricciardi 9b : Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis 2 3a Ocular Surface 19: 313-321, 2021.

 fa J. Klionsky, A. K. Abdel-Aziz,.... CH Mitchell, et al.: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy Page: 1-382, 2021.

 58 A. H. Jassim, D. M. Inman and C. H. Mitchell 2 6a : Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration 2 7 3f Frontiers in Pharmacology 12: 699623, 2021.

 11a Shao, X.; Guha, S.; Lu, W.; Campagno, K.E.; Beckel, J.M.; Mills, J.A.; Yang, W.; Mitchell, C.H., : Polarized cytokine release triggered by P2X7 receptor from retinal pigmented epithelial cells dependent on calcium influx. Cells 23 9: 2537, 2020.

 156 Hersh, E.V.; Moore, P.A.; Grosser, T.; Polomano, R.C.; Farrar, J.T.; Saraghi, M.; Juska, S.A.; Mitchell, C.H.; Theken, K.N., J Dent Res 2020, 99 (7), 777-786: Nonsteroidal anti-inflammatory drugs and opioids in postsurgical dental pain. J Dent Res 99: 777-786, 2020.

 159 Lally, E.T.; Boesze-Battaglia, K.; Dhingra, A.; Gomez, N.M.; Lora, J.; Mitchell, C.H.; Giannakakis, A.; Fahim, S.A.; Benz, R.; Balashova, N., : Aggregatibacter actinomycetemcomitans LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes. Pathogens 9: 74, 2020.

 184 Guan, H.; Nuth, M.; Lee, V.; Lin, C.; Mitchell, C.H.; Lu, W.; Scott, R.W.; Parker, M.H.; Kulp, J.L., 3rd; Reitz, A.B.; Ricciardi, R.P.: Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis. Ocular Surface 19: 313-321, 2020.

 10e Rossi, H.L.; See, L.P.; Foster, W.; Pitake, S.; Gibbs, J.; Schmidt, B.; Mitchell, C.H.; Abdus-Saboor, I.,: Evoked and spontaneous pain assessment during tooth pulp injury. Sci Rep 10: 2759, 2020.

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