Kyong-Mi Chang

faculty photo
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and liver disease pathogenesis in human hepatitis C and B viruses, with and without HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also exploring genetic and clinical databases to better understand and improve human health.

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic viral hepatitis B and C, with and without HIV coinfection. She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research and mentoring VA/Penn dual-appointed Penn faculty at the CMCVAMC.

Selected Publications

Bertram Bengscha, Takuya Ohtani, Ramin Sedaghat Heratia,Niels Bovenschene, Kyong-Mi Chang, E. John Wherry: Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns. Journal of Immunological Methods (in press) 2017.

Ojiro K, Qu X, Cho HS, Park J, Vuidepot A, Lissin N, Molloy PE, Bennett A, Jakobsen BK, Kaplan DE, Riley JL, Chang KM: Modulation of HCV-specific CD8 effector T-cell function with antiviral effect in infectious hepatitis C virus co-culture model. Journal of Virology (in press) 2017.

Wang YJ, Golson ML, Schug J. Traum D, Liu C, Vivek K, Dorrel C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.: Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metabolism 24(4): 616-626, October 2016.

Bengsch, B, Chang KM, : Evolution in our understanding of hepatitis B virus virology and immunology. Clin Liver Dis. 2016 Paul Martin (eds.). Elsevier, 20(3), August 2016.

Chang, KM, Liu M: Chronic hepatitis B: Immune pathogenesis and emerging immunotherapeutics. Current Opin Pharmacol 20: 93-105, August 2016.

Cozen ML, Ryan JC, Shen H, Cheung R, Kaplan DE, Pocha C, Brau N, Aytaman A, Schmidt WN, Pedrosa M, Anand BS, Chang KM, Morgan T, Monto A. : Improved Survival Among all Interferon-α-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders. Dig Dis Sci 61(6): 1744-1756, June 2016.

Park J., DK Wong, AS Wahed, WM Lee, JJ. Feld JJ, N Terrault N, M Khalili, RK. Sterling, KV KowdleY, N Bzowej N, DT. Lau, WR Kim WR, C SmitH, RL Carithers, KW Torrey , JW Keith, DL Levine, D Traum, S Ho, ME Valiga, GS. Johnson, E Doo, ASF. Lok, and KM Chang. : HBV-specific and global T-cell dysfunction in chronic hepatitis B. Gastroenterology 150(3): 684-695, March 2016.

Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM, Murad MH: AASLD guidelines for treatment of chronic hepatitis B. Hepatology 63(1): 261-83, January 2016.

O’Leary TJ., Dominitz JA, Chang KM: Veterans Affairs (VA) Office of Research and Development (ORD): Research Programs and Emerging Opportunities in Digestive Disease Research. Gastroenterology 149(7): 1652-1661, December 2015.

Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS: Present and future therapies of hepatitis B: From discovery to cure. Hepatology 62(6): 1893-908, December 2015.

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Last updated: 03/17/2017
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