Richard J. Schwab, MD
Richard J. Schwab, MD
Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
University of Pennsylvania Medical Center
3624 Market Street, Suite 205
Philadelphia, PA 19104
3624 Market Street, Suite 205
Philadelphia, PA 19104
Office: (215) 349-5477
Fax: (215) 615-4874
Fax: (215) 615-4874
Email:
rschwab@mail.med.upenn.edu
rschwab@mail.med.upenn.edu
Education:
B.A.
Haverford College, 1979.
M.D. (Medicine)
University of Pennsylvania, 1983.
Permanent linkB.A.
Haverford College, 1979.
M.D. (Medicine)
University of Pennsylvania, 1983.
Description of Research Expertise
Dr. Schwab’s research has focused on the pathogenesis of obstructive sleep apnea utilizing novel upper airway imaging techniques. His studies help elucidate the role of the motion of key structures of the upper airway in mediating airway closure. By examining dynamic state-related changes in the upper airway and soft tissue structures surrounding the upper airway he has begun to understand the biomechanics of apneic events. He has studied patients with both magnetic resonance imaging and electronic beam computed tomography during wakefulness and sleep. Several novel findings have resulted from these studies: 1) the anatomic significance of the lateral pharyngeal walls in mediating airway caliber in normals and apneics; and 2) the characterization of the changes in upper airway caliber during the respiratory cycle and the importance of end-expiratory airway narrowing. Dr. Schwab collaborates closely with members of the Departments of Radiology and Biomechanical and Computer Engineering. They have developed state-of-the-art, computer graphics-based analysis software to help model in three dimensions the biomechanical interrelationships between the soft tissue structures and the upper airway.Selected Publications
H Yuan, RJ Schwab, C Kim, J He, J Shults, R Bradford, J Huang, CL Marcus: Relationship between Body Fat Distribution and Upper Airway Dynamic Function during Sleep in Adolescents. SLEEP accepted for publication 2013.Arnardottir ES, Maislin G, Jackson N, Schwab RJ, Benediktsdottir B, Teff K, Juliusson S, Pack AI, Gislason T: The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study. International Journal of Obesity. Macmillan Publishers Limited, advance online publication: 1-8, Sep 2012.
Arnardottir E, Maislin G, Schwab RJ, Pack AI, Gozal D, Gislason T, Olafsson I, Juliusson S, Staley B, Romer M: The interaction of obstructive sleep apnea and obesity on the inflammatory markers C-reactive protein and interleukin-6. The Icelandic Sleep Apnea Cohort. Sleep 35(7): 921-32, July 2012.
Maislin G, Ahmed MM, Gooneratne N, Thorne-Fitzgerald M, Kim C, Teff K, Arnardottir ES, Benediktsdottir B, Einarsdottir H, Juliusson S, Pack AI, Gislason T, Schwab RJ: Single Slice vs Volumetric MR Assessment of Visceral Adipose Tissue - Reliability and Validity Among the Overweight and Obese. Obesity Surgery March (epub ahead of print) 2012.
Schwab RJ: A Quantum Advance in PSG Recordings: The Importance of Head Position in Mediating the AHI. Sleep 34(8): 985-6, Aug 2011.
Chi L, Comyn FL, Mitra N, Reilly MP, Wan F, Maislin G, Chmiewski L, Thorne-Fitzgerald MD, Victor UN, Pack AI, Schwab RJ: Identification of craniofacial risk factors for obstructive sleep apnoea using three-dimensional MRI. Eur Respir J 38(2): 348-58, Aug 2011.
Sutherland K, Deane SA, Chan AS, Schwab RJ, Ng AT, Darendililer MA, Cistulli PA: Comparative Effects of Two Oral Appliances on Upper Airway Structure in Obstructive Sleep Apnea. Sleep 34(4): 469-77, April 2011.
Brennick MJ, Kuna ST, Pickup S, Cater J, Schwab RJ: Respiratory modulation of the pharyngeal airway in lean and obese mice. Respir Physiol Neurobiol 175(2): 296-302, Feb 2011 Notes: Epub 2010 Dec.
Gooneratne NS, Gehrman P, Gurubhagavatula I, Al-Shehabi E, Marie E, Schwab RJ: Effectiveness of ramelteon for insomnia symptoms in older adults with obstructive sleep apnea: a randomized placebo-controlled pilot study. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 6(6): 572-80, Dec 2010.
Lee RW, Sutherland K, Chan AS, Zeng B, Grunstein RR, Darendeliler MA, Schwab RJ, Cistulli PA: Relationship between surface facial dimensions and upper airway structures in obstructive sleep apnea. Sleep 33(9): 1249-54, Sep 2010.
