Home | News | Directories | Calendar | Maps | Contact Us | Webmail
Penn Medicine Advanced Search

Michael Ostap, Ph.D.

Michael Ostap, Ph.D.

faculty photo
Professor of Physiology
Department: Physiology

Contact information
B400 Richards Bldg.
3700 Hamilton Walk/6085
Philadelphia, PA 19104
Office: (215) 573-9758
Education:
B.S. (Chemistry)
Illinois State University, 1988.
Ph.D. (Biochemistry, Molecular Biology, and Biophysics)
University of Minnesota, 1993.
Permanent link
 
School of Medicine > Faculty > Search

Description of Research Expertise

Research Interests
Molecular mechanisms of cell motility

Key words: Cell motility, myosin, actin, biochemistry, single molecule, spectroscopy, microscopy, fluorescence, nanotechnology.

Description of Research
The goal of our research is to understand the molecular mechanisms of cell motility, which include: cell migration, regulation of cell shape and extracellular attachment, and intracellular transport. Cell motility is crucial for several normal and pathological processes, including: cell and tissue development, endocytosis, wound healing, immune response, and metastases of tumors.

Lab Personnel

Jennine Dawicki McKenna, CAMB Student
Elizabeth Feeser, Post-doctoral
Joseph Laakso, BMB Student
Tianming Lin, Research Specialist
Serapion Pyrpassopoulos, Post-doctoral

Selected Publications

E.M. De La Cruz and E.M. Ostap: Kinetic and Equilibrium Analysis of the Myosin ATPase. Methods in Enzymology 455: 157-192, 2009.

J.M. Laakso, J.H. Lewis, H. Shuman, and E.M. Ostap: Myosin-I Can Act as a Molecular Force Sensor. Science 321: 133-136, 2008.

E.M. Ostap: Tropomyosins as Discriminators of Myosin Function. Tropomyosins. Peter Gunning (eds.). Landes Bioscience, 2008.

N. Tang, T. Lin, J. Yang, J.K. Foskett, and E.M. Ostap: CIB1 and CaBP1 Bind to the Myo1c Regulatory Domain. J. Muscle Res. Cell Motil. 28: 285-291, 2007.

E.M. De La Cruz and E.M. Ostap: Actin. Cells. Benjamin Lewin (eds.). Jones and Bartlett, 2007 Notes: Textbook for Graduate and Advanced Undergraduate Students.

S. Manceva, T. Lin, H. Pham, J.H. Lewis, Y.E. Goldman, and E.M. Ostap: Calcium Regulation of Calmodulin Binding to and Dissociation from the Myo1c Regulatory Domain. Biochemistry 48: 11718-11726, 2007.

J.H. Lewis, T. Lin, D.E. Hokanson, and E.M. Ostap: Temperature Dependence of Nucleotide Association and Kinetic Characterization of Myo1b. Biochemistry 45: 11589-11597, 2006 Notes: Identified as a "Hot Article" by the American Chemical Society.

D.E. Hokanson, J.M. Laakso, T. Lin, D. Sept, and E.M. Ostap: Myo1c Binds Phosphoinositides through a Putative PH Domain. Mol. Biol. Cell 17: 4856-4865, 2006.

D.E. Hokanson and E.M. Ostap: Myo1c Binds Tightly and Specifically to PIP2 and InsP3. Proc. Natl. Acad. Sci. 103: 3118-3123, 2006.

back to top
Last updated: 11/20/2009
The Trustees of the University of Pennsylvania