Steven S. Scherer, M.D. Ph.D.
Steven S. Scherer, M.D. Ph.D.
Professor of Neurology
Department: Neurology
Graduate Group Affiliations
Contact information
450 Stemmler Hall
Philadelphia, PA 19104-6077
Philadelphia, PA 19104-6077
Office: (215) 349-5313
Fax: (215) 573-4454
Fax: (215) 573-4454
Publications
Education:
B.S.
University of Michigan, 1977.
M.D.
University of Michigan, 1985.
Ph.D.
University of Michigan, 1985.
Permanent linkB.S.
University of Michigan, 1977.
M.D.
University of Michigan, 1985.
Ph.D.
University of Michigan, 1985.
Description of Research Expertise
RESEARCH INTERESTSMy main interest is the pathogenesis of demyelinating diseases, particularly those caused by mutations in the genes that encode the gap junction proteins Cx32 and Cx47. My current projects in my scientific laboratory relate to (1) the role of Cx32 in the pathogenesis of inherited demyelinating neuropathy, (2) how gap junctions between astrocytes and oligodendrocytes affect the structure/function of CNS myelin, (3) how the myelin sheath organizes the structure of the axon, and (4) animal models of inherited neuropathies. In the clinic, I also participate in a large effort in finding new genetic causes of inherited neuropathies.
Description of Clinical Expertise
The diagnosis and management of peripheral neuropathies.Description of Other Expertise
Clinical electrophysiology - EMGSelected Publications
Scherer, S.S. and K.A. Kleopa : X-linked Charcot-Marie-Tooth disease. Peripheral Neuropathy, 4th edition. P.J. Dyck and P.K. Thomas (eds.). Saunders, Philadelphia Page: 1791-1804, 2005.Scherer, S.S. and E.J. Arroyo: Schwann cells. Encyclopedia of Life Sciences. Macmillan Reference Ltd., London, 2005.
Scherer, S.S. : Hereditary Neuropathies. Encyclopedic Reference of Pain. R.F. Schmidt and W.D. Willis, eds (eds.). Springer-Verlag, 2005 Notes: in press.
Devaux, J.J., and S.S. Scherer: Altered ion channels in an animal model of Charcot-Marie-Tooth disease type IA. J. Neurosci. 25: 1470-1480, 2005.
Scherer, S.S., Y.-T. Xu, A. Messing, K. Willecke, K.H. Fischbeck, and L.J. Bone Jeng : Transgenic expression of human Connexin32 in myelinating Schwann cells prevents demyelination in connexin32-null mice. J. Neurosci. 25: 1550-1559, 2005.
Liang, G.S. Lin, M. de Miguel, J.M. Gomez-Hernandez, J.D. Glass, S.S. Scherer, M. Mintz, L.C. Barrio, and K.H. Fischbeck : Severe neuropathy with leaky connexin32 hemichannels. Ann. Neurol. 57: 749-754, 2005.
Huang, Y., E.E. Sirkowski, J.T. Stickney, and S.S. Scherer : Prenylation-defective human connexin32 mutants are normally localized and function equivalently to wild type connexin32 in myelinating Schwann cells. J. Neurosci. 25: 7111-7120, 2005.
Occhi, S., D. Zambroni, U. Del Carro, S. Amadio, E.E. Sirkowsi, S.S. Scherer, K. Campbell, S.A. Moore, Z.-L. Chen, S. Strickland, A. Di Muzio, A. Uncini, L. Wrabetz, and M.-L. Feltri : Both laminin and Schwann cell dystroglycan are necessary for proper clustering of sodium channels at nodes of Ranvier. J. Neurosci. 21: 9418-9427, 2005.
Devaux, J., K.A. Kleopa, E.C. Cooper*, and S.S. Scherer* : KCNQ2 is a nodal K+ channel. J. Neurosci. 24: 1236-44, 2004 Notes: and Comment.
Kleopa, K.A., J.L. Orthmann, A. Enriquez, D.L. Paul, and S.S. Scherer : Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes. Glia 2004 Notes: In press.