Sharon Diskin,
Sharon Diskin
Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations
Contact information
3501 Civic Center Blvd.
Room 3026, Colket Translational Research Building (CTRB)
Division of Oncology and Center for Childhood Cancer Research
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Room 3026, Colket Translational Research Building (CTRB)
Division of Oncology and Center for Childhood Cancer Research
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Office: (215) 590-9160
Email:
diskin@email.chop.edu
diskin@email.chop.edu
Education:
B.S. (Computer Science)
Villanova University , 1992.
M.S. (Computer Science)
University of Pennsylvania, 2002.
Ph.D. (Genomics and Computational Biology)
University of Pennsylvania, 2008.
Permanent linkB.S. (Computer Science)
Villanova University , 1992.
M.S. (Computer Science)
University of Pennsylvania, 2002.
Ph.D. (Genomics and Computational Biology)
University of Pennsylvania, 2008.
Selected Publications
Diskin Sharon J, Capasso Mario, Schnepp Robert W, Cole Kristina A, Attiyeh Edward F, Hou Cuiping, Diamond Maura, Carpenter Erica L, Winter Cynthia, Lee Hanna, Jagannathan Jayanti, Latorre Valeria, Iolascon Achille, Hakonarson Hakon, Devoto Marcella, Maris John M: Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nature genetics 44(10): 1126-30, Oct 2012.Mayes Patrick A, Degenhardt Yan Y, Wood Andrew, Toporovskya Yana, Diskin Sharon J, Haglund Elizabeth, Moy Christopher, Wooster Richard, Maris John M: Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition. International journal of cancer. Journal international du cancer Sep 2012.
S.J. Diskin, M. Capasso, M. Diamond, E.F. Attiyeh, C. Hou, H. Hakonarson1, M. Devoto, J.M. Maris. : Discovery of rare variants in TP53 associated with neuroblastoma. Advances in Neuroblastoma Research (ANR) 2012. Toronto, Canada. Jun 2012.
S.J. Diskin, M. Capasso, V. Latorre, R. Schnepp, E.F. M. Diamond, E. L. Carpenter, S. Asgharzadeh, R. Seeger, W.B. London, H. Hakonarson1, M. Devoto, J.M. Maris.: Identification and functional relevance of two new susceptibility loci at 6q16 within HACE1 and LIN28B. Advances in Neuroblastoma Research (ANR) 2012. Toronto, Canada Jun 2012.
Bosse Kristopher R, Diskin Sharon J, Cole Kristina A, Wood Andrew C, Schnepp Robert W, Norris Geoffrey, Nguyen Le B, Jagannathan Jayanti, Laquaglia Michael, Winter Cynthia, Diamond Maura, Hou Cuiping, Attiyeh Edward F, Mosse Yael P, Pineros Vanessa, Dizin Eva, Zhang Yongqiang, Asgharzadeh Shahab, Seeger Robert C, Capasso Mario, Pawel Bruce R, Devoto Marcella, Hakonarson Hakon, Rappaport Eric F, Irminger-Finger Irmgard, Maris John M: Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. Cancer research 72(8): 2068-78, Apr 2012.
Latorre Valeria, Diskin Sharon J, Diamond Maura A, Zhang Haitao, Hakonarson Hakon, Maris John M, Devoto Marcella: Replication of neuroblastoma SNP association at the BARD1 locus in African-Americans. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 21(4): 658-63, Apr 2012.
S.J. Diskin, M. Capasso, V. Latorre, R. Schnepp, E.F. Attiyeh, M. Diamond, C. Hou, E. L. Carpenter, H. Lee1, K. A. Cole1, S. Asgharzadeh, R. Seeger, H. Hakonarson1, M. Devoto, J. M. Maris.: Identification of neuroblastoma susceptibility loci at 6q16 within HACE1 and LIN28B. Proceedings of the AACR Annual Meeting, Chicago, IL. Mar-Apr 2012.
Nguyen Le B, Diskin Sharon J, Capasso Mario, Wang Kai, Diamond Maura A, Glessner Joseph, Kim Cecilia, Attiyeh Edward F, Mosse Yael P, Cole Kristina, Iolascon Achille, Devoto Marcella, Hakonarson Hakon, Li Hongzhe K, Maris John M: Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility Loci. PLoS genetics 7(3): e1002026, Mar 2011.
Cole Kristina A, Huggins Jonathan, Laquaglia Michael, Hulderman Chase E, Russell Mike R, Bosse Kristopher, Diskin Sharon J, Attiyeh Edward F, Sennett Rachel, Norris Geoffrey, Laudenslager Marci, Wood Andrew C, Mayes Patrick A, Jagannathan Jayanti, Winter Cynthia, Mosse Yael P, Maris John M: RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America 108(8): 3336-41, Feb 2011.
Wang Kai, Diskin Sharon J, Zhang Haitao, Attiyeh Edward F, Winter Cynthia, Hou Cuiping, Schnepp Robert W, Diamond Maura, Bosse Kristopher, Mayes Patrick A, Glessner Joseph, Kim Cecilia, Frackelton Edward, Garris Maria, Wang Qun, Glaberson Wendy, Chiavacci Rosetta, Nguyen Le, Jagannathan Jayanti, Saeki Norihisa, Sasaki Hiroki, Grant Struan F A, Iolascon Achille, Mosse Yael P, Cole Kristina A, Li Hongzhe, Devoto Marcella, McGrady Patrick W, London Wendy B, Capasso Mario, Rahman Nazneen, Hakonarson Hakon, Maris John M: Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature 469(7329): 216-20, Jan 2011.