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Thomas P. Cappola, M.D., Sc.M.

Thomas P. Cappola, M.D., Sc.M.

faculty photo
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Penn Cardiovascular Institute
11-102 Translational Research Center
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-0805
Fax: 215-615-0828
Lab: 215-573-4650
Education:
A.B. (Chemistry)
Princeton University, 1991.
M.D. (Medicine)
Harvard Medical School, 1995.
Sc.M. (Clinical Investigation )
Johns Hopkins Bloomberg School of Public Health, 2004.
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Description of Research Expertise

My laboratory uses clinical investigation and applied genomics to reveal mechanisms of human heart failure. This has included establishing a multicenter cohort study of advanced heart failure (Penn Heart Failure Study; PHFS) and a multicenter consortium for human myocardial transcriptomics and eQTL mapping (Myocardial Applied Genomics Network; MAGNet). Notable discoveries include the first demonstration that peripheral blood gene expression provides a clinical biomarker to track cardiac allograft rejection, identification of abnormalities in forkhead signaling and neuregulin signaling in common forms of human heart failure, and discovery of the 1p36 HSPB7/CLCNKA locus as the first bonafide genetic risk factor for non-familial heart failure. In my clinical role I treat patients with advanced heart failure on the inpatient and outpatient heart failure/transplant service.

Description of Clinical Expertise

My clinical focus is evaluation and treatment of advance heart failure including medical therapy, device therapy, investigational therapy, and cardiac transplantation

Selected Publications

Zhang KW, French BC, Khan AM, Plappert T, Fang JC, Sweitzer NK, Borlaug BA, Chirinos JA, St. John Sutton M, Cappola TP, Ky B: Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure Journal of the American Heart Association 3(1), Jan 2014.

Chen Horng H, Anstrom Kevin J, Givertz Michael M, Stevenson Lynne W, Semigran Marc J, Goldsmith Steven R, Bart Bradley A, Bull David A, Stehlik Josef, LeWinter Martin M, Konstam Marvin A, Huggins Gordon S, Rouleau Jean L, O'Meara Eileen, Tang W H Wilson, Starling Randall C, Butler Javed, Deswal Anita, Felker G Michael, O'Connor Christopher M, Bonita Raphael E, Margulies Kenneth B, Cappola Thomas P, Ofili Elizabeth O, Mann Douglas L, Dávila-Román Víctor G, McNulty Steven E, Borlaug Barry A, Velazquez Eric J, Lee Kerry L, Shah Monica R, Hernandez Adrian F, Braunwald Eugene, Redfield Margaret M: Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA 310(23): 2533-43, Dec 2013.

Lin Honghuang, Dolmatova Elena V, Morley Michael P, Lunetta Kathryn L, McManus David D, Magnani Jared W, Margulies Kenneth B, Hakonarson Hakon, Del Monte Federica, Benjamin Emelia J, Cappola Thomas P, Ellinor Patrick T: Gene expression and genetic variation in human atria. Heart Rhythm Oct 2013.

Ky Bonnie, French Benjamin, May Khan Abigail, Plappert Ted, Wang Andrew, Chirinos Julio A, Fang James C, Sweitzer Nancy K, Borlaug Barry A, Kass David A, St John Sutton Martin, Cappola Thomas P: Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure. Journal of the American College of Cardiology 62(13): 1165-72, Sep 2013.

Anand Priti, Brown Jonathan D, Lin Charles Y, Qi Jun, Zhang Rongli, Artero Pedro Calderon, Alaiti M Amer, Bullard Jace, Alazem Kareem, Margulies Kenneth B, Cappola Thomas P, Lemieux Madeleine, Plutzky Jorge, Bradner James E, Haldar Saptarsi M: BET bromodomains mediate transcriptional pause release in heart failure. Cell 154(3): 569-82, Aug 2013.

Fox Ervin R, Musani Solomon K, Barbalic Maja, Lin Honghuang, Yu Bing, Ogunyankin Kofo O, Smith Nicholas L, Kutlar Abdullah, Glazer Nicole L, Post Wendy S, Paltoo Dina N, Dries Daniel L, Farlow Deborah N, Duarte Christine W, Kardia Sharon L, Meyers Kristin J, Sun Yan V, Arnett Donna K, Patki Amit A, Sha Jin, Cui Xiangqui, Samdarshi Tandaw E, Penman Alan D, Bibbins-Domingo Kirsten, Bůžková Petra, Benjamin Emelia J, Bluemke David A, Morrison Alanna C, Heiss Gerardo, Carr J Jeffrey, Tracy Russell P, Mosley Thomas H, Taylor Herman A, Psaty Bruce M, Heckbert Susan R, Cappola Thomas P, Vasan Ramachandran S: Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study. Circulation. Cardiovascular genetics 6(1): 37-46, Feb 2013.

Guo Y, Lanktree MB, Taylor KC, Fairfax BP, Elbers CC, Barnard J, Farrall M, Padmanabhan S, Baumert J, Castillo BA, Gaunt TR, Gong Y, Rajagopalan R, Romaine SP, Kumari M, Rafelt S, Smith EN, Li YR, Sivapalaratnam S, van Iperen EP, Speliotes EK, Toskala E, Zhang L, Ochs-Balcom HM, Bhangale TR, Chandrupatla HR, Drenos F, Gieger C, Gupta J, Johnson T, Kleber ME, Makino S, Mangino M, Meng Y, Nelson CP, Pankow JS, Pankratz N, Price TS, Shaffer J, Shen H, Tischfield S, Tomaszewski M, Atwood LD, Bailey KM, Balasubramanyam A, Baldwin CT, Basart H, Bauer F, Behr ER, Beitelshees AL, Berenson GS, Beresford SA, Bezzina CR, Bhatt DL, Boer JM, Braund PS, Burke GL, Burkley B, Carty C, Chen W, Clarke R, Cooper-DeHoff RM, Curtis SP, de Bakker PI, de Jong JS, Delles C, Dominiczak AF, Duggan D, Feldman HI, Furlong CE, Gorski MM, Gums JG, Hardwick R, Hastie C, Heid IM, Huang GH, Huggins GS, Humphries SE, Kirkland SA, Kivimaki M, Klein R, Klein BE, Knowler WC, Kottke-Marchant K, LaCroix AZ, Langaee TY, Li M, Lyon HN, Maiwald S, Marshall JK, Mehta A, Meijs MF, Melander O, Meyer N, Mitra N, Molony CM, Morrow DA, Murugesan G, Newhouse SJ, Nieto JF, Onland-Moret NC, Ouwehand WH, Palmen J, Pepine CJ, Ranchalis J, Rosas SE, Rosenthal EA, Scharnagl H, Schork NJ, Schreiner PJ, Shah T, Shashaty M, Shimbo D, Srinivasan SR, Thomas F, Tobin MD, Tsai MY, Verschuren WM, Wagenknecht LE, Winkelmann BR, Young T, Yusuf S, Zafarmand MH, Zmuda JM, Zwinderman AH, Anand SS, Balmforth AJ, Boehm BO, Boerwinkle E, Burton PR, Cappola TP, Casas JP, Caulfield MJ, Christiani DC, Christie J, Cruickshanks KJ, Davey-Smith G, Davidson KW, Day IN, Doevendans PA, Dorn GW 2nd, FitzGerald GA, Hall AS, Hingorani AD, Hirschhorn JN, Hofker MH, Hovingh KG, Illig T, Jamshidi Y, Jarvik GP, Johnson JA, Kanetsky PA, Kastelein JJ, Koenig W, Lawlor DA, März W, McCaffery J, Mega JL, Mitchell BD, Murray SS, O'Connell JR, Patel SR, Peters A, Pettinger M, Rader DJ, Redline S, Reilly MP, Sabatine MS, Schadt EE, Shuldiner AR, Silverstein RL, Spector TD, Taylor HA, Thorand B, Trip MD, Watkins H, Wichmann HE, Fox CS, Grant SF, Peter I, Talmud PJ, Munroe PB, Wilson JG, Knight JC, Samani NJ, Hegele RA, Asselbergs FW, Monda KL, van der Schouw YT, Demerath EW, Wijmenga C, Timpson NJ, Reiner AP, North KE, Papanicolaou GJ, Hakonarson H, Lange LA, Keating BJ.: Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human molecular genetics 22(1): 184-201, Jan 2013.

Huang Jianhe, Elicker John, Bowens Nina, Liu Xi, Cheng Lan, Cappola Thomas P, Zhu Xiaohong, Parmacek Michael S: Myocardin regulates BMP10 expression and is required for heart development. The Journal of clinical investigation 122(10): 3678-91, Oct 2012.

Li J, Bowens N, Cheng L, Zhu X, Chen M, Hannenhalli S, Cappola TP, Parmacek MS: Myocardin-like protein 2 regulates TGF-beta signaling in embryonic stem cells and the developing vasculature. Development 139(19): 3531-42, Oct 2012.

French Benjamin, Saha-Chaudhuri Paramita, Ky Bonnie, Cappola Thomas P, Heagerty Patrick J: Development and evaluation of multi-marker risk scores for clinical prognosis. Statistical methods in medical research Jul 2012.

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Last updated: 04/16/2014
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