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Perelman School of Medicine at the University of Pennsylvania Advanced Search

Donald M. O'Rourke, M.D.

Donald M. O'Rourke, M.D.

faculty photo
Associate Professor of Neurosurgery
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
Education:
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
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Selected Publications

Chawla S, Oleaga L, Wang SM, Krejza J, Wolf RL, Woo JH, O'Rourke DM, Judy KD, Grady MS, Melhem ER, Poptani H: Role of Proton Magnetic Resonance Spectroscopy in Differentiating Oligodendrogliomas from Astrocytomas. J Neuroimaging 20(1): 3-8, Jan 2010.

Ayuso-Sacido A, Moliterno JA, Kratovac S, Kapoor GS, O'Rourke DM, Holland EC, García-Verdugo JM, Roy NS, Boockvar JA: Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells. J Neurooncol Page: In press, 2010.

Zhan Y, Counelis GJ, O'Rourke DM: The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells. Exp Cell Res 315(14): 2343-2357, Aug 2009.

Kapoor GS, Gocke TA, Chawla S, Whitmore RG, Nabavizadeh A, Krejza J, Lopinto J, Plaum J, Maloney-Wilensky E, Poptani H, Melhem ER, Judy KD, O'Rourke DM: Magnetic resonance perfusion-weighted imaging defines angiogenic subtypes of oligodendroglioma according to 1p19q and EGFR status. J Neuro-oncol 92(3): 373-386, May 2009.

Magge SN, Malik SZ, Royo NC, Chen HI, Yu L, Snyder EY, O'Rourke DM, Watson DJ: Role of Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) in Migration of Neural Progenitor Cells Toward Glial Tumors. J Neurosci Res 87(7): 1547-1555, May 2009.

Gasparetto EL, Pawlak MA, Patel SH, Huse J, Woo JH, Krejza J, Rosenfeld MR, O'Rourke DM, Lustig R, Melhem ER, Wolf RL: Posttreatment Recurrence of Malignant Brain Neoplasm: Accuracy of Relative Cerebral Blood Volume Fraction in Discriminating Low from High Malignant Histologic Volume Fraction. Radiology 50(3): 887-896, Mar 2009.

Wang SM, Kim S, Chawla S, Wolf RL, Zhang WG, O'Rourke DM, Judy KD, Melhem ER, Poptani H: Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging. Neuroimage 44(3): 653-660, Feb 2009.

Yamoutpour F, Bodernpudi V, Park SE, Pan WH, Mauzy MJ, Kratzke RA, Dudek A, Potter DA, Woo RA, O'Rourke DM, Tindall DJ, Farassati F: Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity. Mol Cancer Ther 7(11): 3586-3597, Nov 2008.

Chawla S, Wang S, Wolf RL, Woo JH, Wang J, O'Rourke DM, Judy KD, Grady MS, Melhem ER, Poptani H: Arterial spin-labeling and MR spectroscopy in the differentiation of gliomas. Am J Neuroradiol 28(9): 1683-1689, Oct 2007.

Whitmore RG, Krejza J, Kapoor GS, Huse J, Woo JH, Bloom S, Lopinto J, Wolf RL, Judy K, Rosenfeld MR, Biegel JA, Melhem ER, O'Rourke DM: Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging. J Neurosurg 107(3): 600-609, Sep 2007.

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Last updated: 09/19/2012
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