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John Q. Trojanowski,

John Q. Trojanowski

faculty photo
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
M.D.
Tufts University School of Medicine, 1976.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
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Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Description of Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Nosheny RL, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW, for the Alzheimer’s Disease Neuroimaging Initiative: Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment. Neurobiol Aging 36: 273-282, 2015.

Kalia LV, Lang AE, Hazrati L, Fujioka S, Wszolek ZK, Dickson DW, Ross QA, Van Deerlin VM, Trojanowski JQ, Hurtig HI, Alcalay RN, Marder KS, Clark LN, Gaig C, Tolosa E, Ruiz-Martinez J, Marti Masso J, Ferrer I, Lopez de Munain A, Goldman SM, Schüle B, Langston J, Aasly J, Giordana MT, Bonifati V, Puschmann A, Canesi M, Pezzoli G, Maues de Paula A, Hasegawa K, Duyckaerts C, Brice A, Marras C. : Clinical correlations with Lewy body pathology in LRRK2-related Parkinson’s disease. JAMA Neurol 72: 100-105, 2015.

Perry D, Sperling R, Katz R, Berry D, Dilts D, Hanna D, Salloway S, Trojanowski JQ, Bountra C, Krams M, Luthman J, Potkin S, Gribkoff V, Temple R, Wang Y, Carrillo MC, Stephenson D, Snyder H, Liu E, Ware T, McKew J, Fox A, Fields FO, Bain LJ, Bens C. : Building a roadmap for developing combination therapies for Alzheimer's disease. Expert Rev Neurotherapeutics 2015.

Srivatsal S, Cholerton B, Leverenz JB, Wszolek ZK, Uitti RJ, Weintraub D, Trojanowski JQ, Van Deerlin VM, Quinn JF, Chung KA, Peterson AL, Factor SA,Wood-Siverio C, Goldman JG, Stebbins GT, Bernard B, Ritz B, Rausch R, Espay AJ, Revilla FJ, Devoto J, Rosenthal LS, Dawson TM, Albert MS, Mata IF, Hu S-C, Montine KS, Johnson C, Montine TJ, Edwards KL, Zabetian CP. : Cognitive profile of LRRK2-related Parkinson’s disease. Movement Disorders 2015.

Trojanowski JQ, Arnold SE, Karlawish JH, Xie SX, Van Deerlin VM. : The Penn ADCC: Integrating Neurodegenerative Disease Research Across Disciplines, Conditions, and Population Groups. Brain Degeneration and Dementia in Sub-Saharan Africa. S. Jacobson, S. Musisi (Eds.) (eds.). Springer Verlag, Page: 3-12, 2015.

Goosens J, Vanmechelen E, Trojanowski JW, Lee VM, Van Broeckhoven C, van der Zee J, Engelborghs S. : TDP-43 as a possible biomarkers for frontotemporal lobar degeneration: a systematic review of existing antibodies. Acta Neuropathol Commun 3: 15, 2015.

Apostolova LG, Kristy S, Hwang KS, Avila D, Elashoff D, Kohannim O, Teng EH, Sokolow S, Jack Jr CR, Jagust W, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM, for the Alzheimer’s Disease Neuroimaging Initiative. : Brain amyloidosis ascertainment from cognitive, imaging and peripheral blood protein measures. Neurol 84: 729-737, 2015.

Beecham GW, Dickson D, Scott WK, Martin E R, Schellenberg G, Alzheimer Disease Genetics Consortium, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van -Deerlin VM, Hurtig HI, Mash DC, Beach T, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Vonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz J, Dawson TM, Vance JM. : The PARK 10 locus is a major locus for sporadic, neuropathologically-confirmed Parkinson disease. Neurol 84: 972-980, 2015.

Cirulli ET, Lasseigne BN, Petrovski S, Sapp P, Dion P, Leblond C, Couthouis J, Lu Y-F, Wang Q, Keebler J, Krueger BJ, Ren N, Levy SE, Boone BE, Wimbish JR, Jones LW, Jones A, Carulli J, Day-Williams A, Staropoli J, Xin WW, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider N, Chung W, Ravits JM, Glass JD, Sims KB, Van Deerlin V, Maniatis T, Harper W, Allen A, Bedlack RS, Gitler A, Rouleau G, Brown R, Harms MB, Cooper G, Harris T, Myers RM, Goldstein DB. : The exomes of 3,500 patients identify new ALS genes and pathways. Science 347: 1436-1441, 2015.

Brettschneider J, Del Tredici K, Lee VM-Y, Trojanowski JQ. : Spreading of pathology in neurodegenerative diseases: A focus on human studies. Nat Rev Neurosci 16: 109-120, 2015.

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Last updated: 07/29/2015
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