John Q. Trojanowski, MD, PhD

faculty photo
William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Center for Neurodegenerative Disease Researh
University of Pennsylvania School of Medicine
3600 Spruce Street
3rd Floor Maloney Building
Philadelphia, PA 19104-4283
Office: 215-662-6399
Fax: 215-349-5909
Lab: 215-662-3292
Education:

University of Vienna, Vienna, Austria, 1969.
B.A. (German)
King's College (1965-1967 & 1969-1970), 1970.

Erasmus University Rotterdam, Rotterdam, The Netherlands, 1974.
M.D.
Tufts University School of Medicine, 1976.
Ph.D. (Neuroanatomy)
Tufts University Graduate School of Arts and Sciences, 1976.
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Description of Research Expertise

RESEARCH INTERESTS
Neurodegenerative diseases caused by filamentous aggregates of A-beta, tau and alpha-synuclein as well as in vitro and animal models of these diseases.

RESEARCH TECHNIQUES
Morphological, genetic, molecular biological and biochemical methods are used to study samples from patients with neurodegenerative diseases as well as those from model systems.

RESEARCH SUMMARY
Research currently centers on molecular mechanisms of neuron dysfunction, degeneration and death in normal aging and in neurodegenerative diseases (Alzheimer's and Parkinson's disease, frontotemporal dementias with/without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Description of Clinical Expertise

Morphological, genetic, molecular and biological analysis of samples from patients with neurodegenerative diseases as well as those from model systems.

Description of Other Expertise

Research currently centers on molecular mechanisms of neuron dysfunction, degeneration, and death in normal aging and in neurodegenerative diseases (AD and PD, frontotemporal dementias (FTD) with and without parkinsonism, motor neuron disease, etc.). This research uses immunological, biochemical, genetic, molecular, and morphological methods to study human CNS and PNS tissue samples (postmortem or surgical), cell lines, synthetic proteins, and transgenic models of neurodegenerative diseases.

Selected Publications

Wenning Gregor, Trojanowski John Q, Kaufmann Horacio, Wisniewski Thomas, Rocca Walter A, Low Phillip A: Is multiple system atrophy an infectious disease? Annals of neurology Jan 2018.

He Zhuohao, Guo Jing L, McBride Jennifer D, Narasimhan Sneha, Kim Hyesung, Changolkar Lakshmi, Zhang Bin, Gathagan Ronald J, Yue Cuiyong, Dengler Christopher, Stieber Anna, Nitla Magdalena, Coulter Douglas A, Abel Ted, Brunden Kurt R, Trojanowski John Q, Lee Virginia M-Y: Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature medicine 24(1): 29-38, Jan 2018.

Rey Nolwen L, George Sonia, Steiner Jennifer A, Madaj Zachary, Luk Kelvin C, Trojanowski John Q, Lee Virginia M-Y, Brundin Patrik: Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta neuropathologica 135(1): 65-83, Jan 2018.

Irwin David J, McMillan Corey T, Xie Sharon X, Rascovsky Katya, Van Deerlin Vivianna M, Coslett H Branch, Hamilton Roy, Aguirre Geoffrey K, Lee Edward B, Lee Virginia M Y, Trojanowski John Q, Grossman Murray: Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a journal of neurology 141(1): 288-301, Jan 2018.

Guerreiro Rita, Ross Owen A, Kun-Rodrigues Celia, Hernandez Dena G, Orme Tatiana, Eicher John D, Shepherd Claire E, Parkkinen Laura, Darwent Lee, Heckman Michael G, Scholz Sonja W, Troncoso Juan C, Pletnikova Olga, Ansorge Olaf, Clarimon Jordi, Lleo Alberto, Morenas-Rodriguez Estrella, Clark Lorraine, Honig Lawrence S, Marder Karen, Lemstra Afina, Rogaeva Ekaterina, St George-Hyslop Peter, Londos Elisabet, Zetterberg Henrik, Barber Imelda, Braae Anne, Brown Kristelle, Morgan Kevin, Troakes Claire, Al-Sarraj Safa, Lashley Tammaryn, Holton Janice, Compta Yaroslau, Van Deerlin Vivianna, Serrano Geidy E, Beach Thomas G, Lesage Suzanne, Galasko Douglas, Masliah Eliezer, Santana Isabel, Pastor Pau, Diez-Fairen Monica, Aguilar Miquel, Tienari Pentti J, Myllykangas Liisa, Oinas Minna, Revesz Tamas, Lees Andrew, Boeve Brad F, Petersen Ronald C, Ferman Tanis J, Escott-Price Valentina, Graff-Radford Neill, Cairns Nigel J, Morris John C, Pickering-Brown Stuart, Mann David, Halliday Glenda M, Hardy John, Trojanowski John Q, Dickson Dennis W, Singleton Andrew, Stone David J, Bras Jose: Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology 17(1): 64-74, Jan 2018.

Wang Hua, Stewart Tessandra, Toledo Jon B, Ginghina Carmen, Tang Lu, Atik Anzari, Aro Patrick, Shaw Leslie M, Trojanowski John Q, Galasko Douglas R, Edland Steven, Jensen Poul H, Shi Min, Zhang Jing: A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD 61(4): 1541-1553, 2018.

Berson Amit, Sartoris Ashley, Nativio Raffaella, Van Deerlin Vivianna, Toledo Jon B, Porta Sílvia, Liu Shichong, Chung Chia-Yu, Garcia Benjamin A, Lee Virginia M-Y, Trojanowski John Q, Johnson F Brad, Berger Shelley L, Bonini Nancy M: TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Current biology : CB 27(23): 3579-3590.e6, Dec 2017.

Horgusluoglu-Moloch Emrin, Nho Kwangsik, Risacher Shannon L, Kim Sungeun, Foroud Tatiana, Shaw Leslie M, Trojanowski John Q, Aisen Paul S, Petersen Ronald C, Jack Clifford R, Lovestone Simon, Simmons Andrew, Weiner Michael W, Saykin Andrew J: Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging 60: 92-103, Dec 2017.

Perry David C, Brown Jesse A, Possin Katherine L, Datta Samir, Trujillo Andrew, Radke Anneliese, Karydas Anna, Kornak John, Sias Ana C, Rabinovici Gil D, Gorno-Tempini Maria Luisa, Boxer Adam L, De May Mary, Rankin Katherine P, Sturm Virginia E, Lee Suzee E, Matthews Brandy R, Kao Aimee W, Vossel Keith A, Tartaglia Maria Carmela, Miller Zachary A, Seo Sang Won, Sidhu Manu, Gaus Stephanie E, Nana Alissa L, Vargas Jose Norberto S, Hwang Ji-Hye L, Ossenkoppele Rik, Brown Alainna B, Huang Eric J, Coppola Giovanni, Rosen Howard J, Geschwind Daniel, Trojanowski John Q, Grinberg Lea T, Kramer Joel H, Miller Bruce L, Seeley William W: Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain : a journal of neurology 140(12): 3329-3345, Dec 2017.

Phillips Jeffrey S, Da Re Fulvio, Dratch Laynie, Xie Sharon X, Irwin David J, McMillan Corey T, Vaishnavi Sanjeev N, Ferrarese Carlo, Lee Edward B, Shaw Leslie M, Trojanowski John Q, Wolk David A, Grossman Murray: Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of aging 63: 75-87, Nov 2017.

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Last updated: 01/30/2018
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