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Paul A. Yushkevich, Ph.D.

Paul A. Yushkevich, Ph.D.

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Associate Professor of Radiology
Department: Radiology

Contact information
3600 Market St.
Suite 370
Philadelphia, PA 19104
Office: 703-593-8373
Lab: 215-349-8020
B.S. (Computer Science and Mathematics)
University of North Carolina at Charlotte, 1996.
M.S. (Computer Science)
University of North Carolina Chapel Hill, 2000.
Ph.D. (Computer Science)
University of North Carolina Chapel Hill, 2003.
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Description of Research Expertise

My research portfolio combines theoretical work on statistical shape characterization using a symmetry-based representation of shape with applied and translational research in multiple areas of biomedical image analysis. I am particularly interested in analysis techniques that are tailored to specific anatomical structures. My key work in this area involves automatic segmentation and morphometry of the hippocampal formation (HF) in magnetic resonance imaging (MRI). The HF plays a central role in memory function and is a site of early neurodegeneration in Alzheimer’s disease. In a broad effort to develop more detailed imaging-based biomarkers for Alzheimer’s disease, my team has developed a first of its kind detailed computational atlas of the HF from postmortem MRI microscopy. With NIH R01 funding, we are now integrating this atlas with histology, leveraging it for the analysis of the HF and its subfields in in vivo MRI, and evaluating MRI-derived subfield-specific as alternative imaging biomarkers in dementia. We recently published a pioneering technique for automatic segmentation of HF subfields in high-resolution, HF-focused T2-weighted in vivo MRI, showing excellent agreement with manual segmentation. Concurrently, we developed and evaluated a strategy for improving the accuracy of general-purpose segmentation techniques using machine learning as a corrective wrapper method. Other recent publications include a surface-based tract-specific strategy for diffusion MRI analysis, for which open-source software is currently being developed, and an automatic cardiac MRI segmentation method with an explicit prior on heart wall thickness.

Selected Publications

Yushkevich PA, Pluta JB, Wang H, Xie L, Ding SL, Gertje EC, Mancuso L, Kliot D, Das SR, Wolk DA.: Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment. Hum Brain Mapping Sep 2014.

Witschey WR, Contijoch F, McGarvey JR, Ferrari VA, Hansen MS, Lee ME, Takebayashi S, Aoki C, Chirinos JA, Yushkevich PA, Gorman JH 3rd, Pilla JJ, Gorman RC.: Real-time magnetic resonance imaging technique for determining left ventricle pressure-volume loops. The Annals of thoracic surgery 97(5): 1597-1603, May 2014.

Sandhitsu Das, John Pluta, Paul Yushkevich, David A Wolk: Mtl subregional morphometry using high resolution mri in adni2. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 10(4): 696, Jan 2014.

Adler Daniel H, Pluta John, Kadivar Salmon, Craige Caryne, Gee James C, Avants Brian B, Yushkevich Paul A: Histology-derived volumetric annotation of the human hippocampal subfields in postmortem MRI. NeuroImage 84: 505-23, Jan 2014.

Pouch Alison M, Vergnat Mathieu, McGarvey Jeremy R, Ferrari Giovanni, Jackson Benjamin M, Sehgal Chandra M, Yushkevich Paul A, Gorman Robert C, Gorman Joseph H: Statistical assessment of normal mitral annular geometry using automated three-dimensional echocardiographic analysis. The Annals of thoracic surgery 97(1): 71-7, Jan 2014.

Pouch A M, Wang H, Takabe M, Jackson B M, Gorman J H, Gorman R C, Yushkevich P A, Sehgal C M: Fully automatic segmentation of the mitral leaflets in 3D transesophageal echocardiographic images using multi-atlas joint label fusion and deformable medial modeling. Medical image analysis 18(1): 118-29, Jan 2014.

Francisco Contijoch*, Kelly Rogers, Brian Avants, Paul Yushkevich, Vahid Hoshmand, Robert C Gorman, Yuchi Han and Walter R Witschey: Quantification of left ventricular deformation fields from undersampled radial, real-time cardiac MRI. Journal of Cardiovascular Magnetic Resonance 2014 16(1): 366, Jan 2014.

Sandhitsu Das, John Pluta, Lauren Mancuso, Dasha Kliot, Paul Yushkevich, David A Wolk: Involvement of anterior and posterior medial temporal lobe networks in early Alzheimer's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Elsevier (eds.). 10(4): 822, Jan 2014.

Walter R Witschey, Francisco Contijoch, Jeremy R McGarvey, Victor A Ferrari, Michael Hansen, Julio Chirinos, Paul Yushkevich, Joseph H Gorman, Robert C Gorman, James J Pilla: The Frank-Starling relationship of the heart revealed in a large animal study utilizing real-time undersampled radial MRI at variable inotropic state and heart rate. Journal of Cardiovascular Magnetic Resonance 16(1): 57, Jan 2014.

Long Xie, John Pluta, Hongzhi Wang, Sandhitsu R Das, Lauren Mancuso, Dasha Kliot, Brian B Avants, Song-Lin Ding, David A Wolk, Paul A Yushkevich: Automatic Clustering and Thickness Measurement of Anatomical Variants of the Human Perirhinal Cortex. Medical Image Computing and Computer-Assisted Intervention–MICCAI 2014 8675: 81-88, Jan 2014.

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Last updated: 10/06/2014
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