Marcia Simpson Brose, MD PhD
Marcia Simpson Brose, MD PhD
Assistant Professor of Otorhinolaryngology: Head and Neck Surgery
Department: Otorhinolaryngology: Head and Neck Surgery
Graduate Group Affiliations
Contact information
Clinical Research Building (CRB), Room 127
415 Curie Blvd.
Philadelphia, PA 19104
415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-6344
Fax: 215-573-1934
Fax: 215-573-1934
Email:
brosem@mail.med.upenn.edu
brosem@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
PUBMED link
Otorhinolaryngology Department Home Page
Primary Work Website
Search PubMed for articles
PUBMED link
Otorhinolaryngology Department Home Page
Primary Work Website
Education:
B.A. (Biology)
Amherst College, Amherst, MA, 1986.
Ph.D. (Genetics and Developmental Biology)
Rockefeller University, New York, NY, 1994.
M.D. (Medicine)
Cornell University Medical College, New York, NY, 1995.
Permanent linkB.A. (Biology)
Amherst College, Amherst, MA, 1986.
Ph.D. (Genetics and Developmental Biology)
Rockefeller University, New York, NY, 1994.
M.D. (Medicine)
Cornell University Medical College, New York, NY, 1995.
Description of Research Expertise
Dr Brose runs a lab in the field of tranlsational studies in cancer genetics and genomics. Dr. Brose’s basic science research interest involves the identification of genetic abnormalities in the tumors of patients undergoing targeted therapies. She currently has projects underway in thyroid cancer, breast cancer, lung cancer, colon cancer and esophageal cancer. Once identified, she is interested in understanding if these changes may identify tumors that may have or lack resistance to certain compounds. She has experience in the use of mice, drosophila, human tissue culture and clincial tissue samples. Her analytic tools include all types of PCR, RT-PCR, as well as the use of array comparative genomic hybridization (aCGH) and transcription profiling, taqman analysis, Q-RT-PCR and DNA sequencing on a regular basis. She also uses high resolution expression and SNP genotyping tetchnologies (Affymetrix and Illumina) to study the genetic basis of cancer. Dr. Brose provides the key correlative science for ongoing phaseI/II/III clinical trials at the University and internationally.Description of Clinical Expertise
Familial cancer syndromes and cancer risk evaluation, PhaseI/II clinical trials, novel drug target discovery, and use of genetic testing in diagnosis, prognostication and treatment of cancer. Treatment of advanced thyroid cancer and cancers of the head and neck, lung and esophagus.Description of Other Expertise
Teaches residents and medical student who rotate through her lab in Hematology/Oncology and Cell geneticsSelected Publications
Ma, C., Quesnelle1, K.M., Sparano, A., Rao, S, Park, M.S., Cohen, M.A., Wang, Y., Samanta, M, Kumar, M.S., Aziz, M.U. Naylor, T., Weber, B.L., Fakharzadeh, S.S., Weinstein, G.S., Vachani, A., Feldman, M.D., and Brose, M.S.: Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues. Cancer Biology and Therapy 8(10): 1-10, May 2009 Notes: Cancer Biology & Therapy 8:10, 1-10; 15 May 2009.Adam J. Bass1,2,4,5,17, Hideo Watanabe1,4,5,17, Soyoung Yu1,4, Craig H. Mermel1,4,5, Sven Perner6,7, Roel G. Verhaak1,4,5, So Young Kim1,4, Leslie Wardwell1,4, Pablo Tamayo5, Irit Gat-Viks5, Alex H. Ramos1,4,5, Michele S. Woo1,4,5, Barbara A. Weir1,4,5, Gad Getz5, Rameen Beroukhim1,2,4,5, Michael O’Kelly5, Amit Dutt1,4,5, Orit Rozenblatt-Rosen1,4, Piotr Dziunycz1, Justin Komisarof1, Lucian R. Chirieac3, Christopher J. LaFargue6, Veit Scheble7, Theresia Wilbertz7, Changqing Ma8, Shilpa Rao8, Hiroshi Nakagawa10, Douglas B. Stairs10, Lin Lin11, Thomas J. Giordano12, Patrick Wagner6, John D. Minna13, Adi F. Gazdar13, Chang Qi Zhu14, Marcia S. Brose8,9, Ivan Cecconello15, Ulysses Ribeiro Jr.15, Suely K. Marie15, Olav Dahl16, Ramesh A. Shivdasani1,2, Ming-Sound Tsao14, Mark A. Rubin6, Kwok K. Wong1,2, Aviv Regev5, William C. Hahn1,2,4,5, David G. Beer11, Anil K. Rustgi10, Matthew Meyerson1,3,4,5: SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas. Nature Genetics in press, 2009.
Gupta-Abramson V, Troxel AB, Nellore A, Puttaswamy K, Redlinger M, Ransone K, Mandel SJ, Flaherty KT, Loevner LA, O'Dwyer, PJ, Brose MS: Phase II Trial of Sorafenib in Advanced Thyroid Cancer. Journal of Clinical Oncology 26(29): 4714-4719, October, Epub June 9 2008.
Keith T. Flaherty, Joan Schiller, Lynn M. Schuchter, Glenn Liu, David A. Tuveson, Maryann Redlinger, Chetan Lathia, Chenghua Xia, Oana Petrenciuc, Sunil R. Hingorani, Michael A. Jacobetz, Patricia A. Van Belle, David Elder, Marcia S. Brose, Barbara L. Weber, Mark R. Albertini, and Peter J. O'Dwyer : A Phase I Trial of the Oral, Multikinase Inhibitor Sorafenib in Combination with Carboplatin and Paclitaxel. Clin. Cancer Res. 14: (15): 4836-4842. August 2008.
Anoma Nellore, Karolina Paziana, Changqing Ma, Oxana M. Tsygankova, Yan Wang, Kanchan Puttaswamy, Ammarah U. Iqbal, Susanna R. Franks, Yu Lv, Andrea B. Troxel, Michael D. Feldman, Judy L. Meinkoth, and Marcia S. Brose : Loss of Rap1GAP in Papillary Thyroid Cancer J Clin Endocrinol Metab E-Pub(doi:10.1210/jc.2008-1042), e-pub, December 2008 Notes: In Print: Mar 2009; 94: 1026 - 1032.
Tsygankova OM, Prendergast GV, Puttaswamy K, Wang Y, Feldman MD, Wang H, Brose MS, Meinkoth JL.: Downregulation of Rap1GAP Contributes to Ras Transformation. Molecular and Cellular Biology 27(19): 6647-6658, October, Epub Jul 23 2007
O'Donnell RK, Mick R, Feldman M, Hino S, Wang Y, Brose MS, Muschel RJ.: Distribution of dendritic cell subtypes in primary oral squamous cell carcinoma is inconsistent with a functional response. Cancer Letters 255(1): 145-152, September 2007.
Spittle C, Ward MR, Nathanson KL, Gimotty PA, Rappaport E, Brose MS, Medina A, Letrero R, Herlyn M, Edwards RH. : Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma The Journal of Molecular Diagnostics 9(4): 464-471, September 2007.
Anil Vachani, Michael Nebozhyn, Sunil Singhal, Linda Alila, Elliot Wakeam, Ruth Muschel, Charles A. Powell, Patrick Gaffney, Bhuvanesh Singh, Marcia S. Brose, John Kucharczuk, Larry R. Kaiser, J. Stephen Marron, Michael K. Showe, Steven M. Albelda, Louise C. Showe: Identification of 10 Gene Classifier for Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma: Towards a Distinction between Primary and Metastatic Squamous Cell Carcinoma of the Lung. Clinical Cancer Research 13(10): 2905-2915, May 2007.
Baloch , ZW, Puttaswamy, K.,Brose, M. and LiVolsi ,VA: Lack of BRAF mutations in hyalinizing trabecular neoplasm. Cytojournal 25(3): 17, July 2006.
| Protocol | Title | Status |
|---|---|---|
| 802861 | UPCC 03305 Phase II Study BAY 43-9006 in Patients With Metastatic Thyroid Cancer | Recruiting |