Kathleen M. Loomes, MD
Kathleen M. Loomes, MD
Associate Professor of Pediatrics at the Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
The Children's Hospital of Philadelphia
Division of Gastroenterology, Hepatology and Nutrition, 7th floor
34th and Civic Center Blvd.
Philadelphia, PA 19104
Division of Gastroenterology, Hepatology and Nutrition, 7th floor
34th and Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-7223
Fax: 267-426-7814
Fax: 267-426-7814
Email:
loomes@email.chop.edu
loomes@email.chop.edu
Education:
B.A. (Biology)
Rice University (Cum laude), 1988.
M.D. (Medicine)
University of Texas Southwestern Medical School, 1992.
Permanent linkB.A. (Biology)
Rice University (Cum laude), 1988.
M.D. (Medicine)
University of Texas Southwestern Medical School, 1992.
Selected Publications
Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA, Spinner NB, Horn D, Shults J, Leonard MB, Grimberg A and Loomes KM: Pathologic Lower Extremity Fractures in Children with Alagille Syndrome. J Pediatr Gastroenterol Nutr 51(1): 66-70, 2010.Bauer RC, Laney AO, Smith R, Gerfen J, Morrissette JJD, Loomes KM, Krantz ID, Gelb BD, Goldmuntz E and Spinner NB: Jagged1 Mutations in Patients with Tetralogy of Fallot or Pulmonic Stenosis. Hum Mutat 31(5): 594-601, 2010.
Golson ML, Le Lay J, Gao N, Bramswig N, Loomes KM, Oakey RJ, May CL, White P and Kaestner KH: Jagged1 is a competitive inhibitor of Notch signaling in the developing endocrine pancreas. Mech Dev 126(8): 687-99, 2009.
High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS and Epstein JA: Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest 119(7): 1986-96, 2009.
Golson ML, Loomes KM, Oakey R and Kaestner KH: Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion. Gastroenterology 136(5): 1761-71, 2009.
High, Frances A. Lu, Min Min. Pear, Warren S. Loomes, Kathleen M. Kaestner, Klaus H. Epstein, Jonathan A.: Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proceedings of the National Academy of Sciences of the United States of America 105(6): 1955-9, Feb 12 2008.
Ryan MJ, Bales C, Nelson A, Gonzalez DM, Underkoffler LA, Segalov M, Wilson-Rawls J, Cole S, Moran JL, Russo P, Spinner NB, Kusumi K and Loomes KM : Bile Duct Proliferation in Jag1/Fringe Heterozygous Mice Identifies Candidate Modifiers of the Alagille Syndrome Hepatic Phenotype Hepatology 48(6): 1989-97, 2008.
Loomes KM, Stevens SA, O'Brien ML, Gonzalez DM, Ryan MJ, Segalov M, Dormans NJ, Mimoto MS, Gibson JD, Sewell W, Schaffer AA, Nah, H-D, Rappaport EF, Pratt SC, Dunwoodie SL, Kusumi K: Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects. Developmental Dynamics 236(10): 2943-51, Oct 2007.
Loomes KM, Russo P, Ryan M, Nelson A, Underkoffler L, Glover C, Fu H, Gridley T, Kaestner KH, Oakey RJ: Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology 45(2): 323-30, Feb 2007.
Choi JD, Underkoffler LA, Wood AJ, Collins JN, Williams PT, Golden JA, Schuster,Jr. EF, Loomes KM, Oakey RJ: A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island. Molecular & Cellular Biology 25(13): 5514-22, Jul 2005.