Sukhamay Lahiri, D. Phil.

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Department: Physiology

Contact information
Department of Physiology
B400 Richards Building
University of Pennsylvania School of Medicine
Philadelphia, PA 19104-6085
Office: (215) 898-9125
Fax: (215) 573-5851
Calcutta University, Calcutta, India, 1949.
Calcutta University, Calcutta, India, 1951.
Calcutta University, Calcutta, India, 1956.
Oxford University, Oxford, England, 1959.
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Description of Research Expertise

The unit structure in carotid and aortic bodies consists of several epithelioid cells often innervated by a single nerve fiber and surrounded by a few supporting cells. Low oxygen and high carbon dioxide pressures increase discharge frequency of the nerve fiber, and the effect of one stimulus is augmented by another. The physiological function of this cellular response is to monitor oxygen and carbon dioxide pressures in the arterial blood and generate appropriate systemic reflexes. The focus of laboratory research is on the mechanisms by which oxygen and carbon dioxide elicit the cellular response and to identify the cellular components responsible for the response. A working hypothesis is that oxygen sensor is located within the glomus cell, and the sensing mechanism involves oxygen metabolism which controls release of the neurotransmitter. Carbon dioxide detection is mediated by a separate but closely related mechanism. A link between oxygen and carbon dioxide chemoreception presumably exists at the level of a protein receptor near the synaptic junction between the glomus cells and the nerve. The identification of the mechanisms will be aided by the fact that oxygen sensitive mechanism will show adaptive structural and functional responses to chronic stimuli of low and high oxygen pressures. The study uses biochemical, biophysical and cytological techniques.

Selected Publications

Rozanov C., Roy A., Mokashi A., Daudu P., Lahiri S.: Barium-stimulated chemosensory activity may not reflect inhibition of background voltage-insensitive K+ channels in the rat carotid body. Brain Research 897(1-2): 1-8, Apr 6 2001.

Roy A., Mokashi A., Rozanov C., Daudu PA., Lahiri S.: Reduced glutathione, dithiothreitol and cytochrome P-450 inhibitors do not influence hypoxic chemosensory responses in the rat carotid body. Brain Research 889(1-2): 131-7, Jan 19 2001.

Lahiri S., Nayak D., Ramaswami A., Manohor SB.: Separation of carrier-free ytterbium and thulium produced in 80 MeV 12C6+ irradiated gadolinium foil target by liquid-liquid extraction with HDEHP. Applied Radiation & Isotopes 52(4): 797-802, Apr 2000.

Rozanov C., Roy A., Mokashi A., Wilson DF., Lahiri S., Acker H.: Chemosensory response to high pCO is blocked by cadmium, a voltage-sensitive calcium channel blocker. Brain Research 833(1): 101-7, Jun 26 1999.

Lahiri, S., Ehleben, W. and Acker, H: Dependence on Reme ligands of chemoreceptor discharge and cytochrome redox changes of the rat carotid body. PNAS 96: 9427-9432, 1999.

Mokashi A., Roy A., Rozanov C., Osanai S., Storey BT., Lahiri S.: High PCO does not alter pHi, but raises [Ca2+]i in cultured rat carotid body glomus cells in the absence and presence of CdC12. Brain Research 803(1-2): 194-7, Aug 24 1998.

Buerk DG., Osanai S., Mokashi A., Lahiri S.: Dopamine, sensory discharge, and stimulus interaction with CO2 and O2 in cat carotid body. Journal of Applied Physiology 85(5): 1719-26, Nov 1998.

Di Giulio C., Huang W., Mokashi A., Lahiri S.: Further characterization of stimulus interaction of cat carotid chemoreceptors. Journal of the Autonomic Nervous System 71(2-3): 196-200, Jul 15 1998.

Iturriaga R., Mokashi A., Lahiri S.: Anion exchanger and chloride channel in cat carotid body chemotransduction. Journal of the Autonomic Nervous System 70(1-2): 23-31, May 28 1998.

Rozanov C., Buerk DG., Chugh D., Mokashi A., Lahiri S.: Inhibition of dopamine release with simultaneous chemosensory excitation by hypercapnia with and without [Ca2+]0 in the cat carotid body. Journal of the Autonomic Nervous System 69(2-3): 184-9, Apr 30 1998.

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Last updated: 02/29/2000
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