Hongzhe Li (Lee), Ph.D.
Hongzhe Li (Lee), Ph.D.
Professor of Biostatistics in Biostatistics and Epidemiology
Department: Biostatistics and Epidemiology
Graduate Group Affiliations
Contact information
215 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: 215-573-5038
Fax: 215-573 1050
Fax: 215-573 1050
Email:
hongzhe@upenn.edu
hongzhe@upenn.edu
Education:
B.S. (Mathematics/Information)
Peking University, 1989.
Ph.D. (Statistics)
University of Washington, 1995.
Permanent linkB.S. (Mathematics/Information)
Peking University, 1989.
Ph.D. (Statistics)
University of Washington, 1995.
Description of Research Expertise
My methods reserach was mostly motivated by problems in genetics and genoimics. I have worked on a variety problems in statistical genetics and genomics, including methods for family-based genetic linkage and association analysis, methods for admixture mapping, methods for genome-wide association analysis, methods for analysis of microarray time course gene expression data, high dimensional regression analysis for genomic data, methods for copy number variation analysis and methods for analysis of next generation sequence data. I have published both statistical methodological research in top statistics/biostatistics journals (JASA, AOS, AOAS, Biometrika, Biometrics, Biostatistics etc ) and in top genetics journals (AJHG, Plos Genetics, etc) and collaborative research in top scientific journals (Science, NEJM, Nature, Nature Genetics, PNAS, Developmental Cell etc).Selected Publications
Huang, J., Ma, S., Li, H., and Zhang, C.H.: The Sparse Laplacian Shrinkage Estimator for High-Dimensional Regression. Annals of Statistics 39(4): 2021*2046, 2011.Xie, J., Cai, T.T., Li, H.: Sample Size and Power Analysis for Sparse Signal Recovery in Genome-Wide Association Studies. Biometrika 98(2): 273-290, 2011.
Fairless, A.H., Shah, R.Y., Guthrie, A.J., Li, H., and Brodkin, E.S.: Deconstructing Sociability, an Autism-relevant phenotype, in mouse models. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 294(10): 1713-1725, 2011.
Wang, K., Sharon, J., Diskin, E.F., Attiyeh, C.W., Schnepp, R.W., Diamond, M., Zhang, H., Hou, G., Bosse, K., Mayes, P.A., Glessner, J., Kim, C., Frackelton, E., Garris, M., Wang, Q., Glaberson, W., Chiavacci, R., Le, Nguyen., Saeki, N., Sasaki, H., Grant, S.F.A., Mosse], Y.P., Iolascon, A., Li, H., Devoto, M., McGrady, P.W., London, W.B., Capasso, M., Rahman, N., Hakonarson, H., Maris, J.M. : Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature 469: 216-220, 2011.
Wu GD, *Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H, Bushman FD, Lewis JD : Linking long-term dietary patterns with gut microbial enterotypes. Science 334(96052 0): 105-108, 2011.
Chen, J., *Xie, J., and Li, H.: A penalized likelihood approach for bivariate conditional normal models for dynamic co-expression analysis. Biometrics 67(1): 299-308, 2011.
Dow, H., Kaercher, K., Sankoorikal, G., Pauley, E., Lohoff, F., Ferraro, T., Li, H., Brodkin, E. : Genetic dissection of intermale aggressive behavior in BALB/cJ and A/J mice. Genes, Brain and Behavior 10: 57-68, 2011.
Winter, C., Austin, R.S., Blanvillain-Baufumé, B., Reback, M.A., Monniaux, M., Wu, M.F., Sang, Y., Yamaguchi, A., Yamaguchi, N., Parker, J.E., Parcy, F., Jensen, S.T., Li, H., and Wagner, D.: LEAFY Target Genes Reveal a Direct Link Between Biotic Stimulus Response and Flower. Developmental Cell 20(4): 430-443, 2011.
*Nguyen, L.B., Diskin, S.J., Cappasso, M., Wang, K., Diamond, M.A., Glessner, J., Kim, C., Attiyeh, E.F., Mosse, Y.P., Cole, K., Lolascon, A., Devoto, M., Hakonarson, H., Li, H., Maris, J.M. : Phenotype Restricted Genome-Wide Association Study Using a Gene-Centric Approach Identifies Three Low-Risk Neuroblastoma Susceptibility Loci. PLoS Genetics 7(3): e1002026, 2011 Notes: doi:10.1371/journal.pgen.1002026.
Wei, X., Huang, J., and Li, H.: Variable selection and estimation in high-dimensional varying-coefficient models. Statistica Sinica 103(484): 1556-1569, 2011.