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Wei-Ting Hwang, Ph.D.

Wei-Ting Hwang, Ph.D.

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Associate Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology
Graduate Group Affiliations

Contact information
Department of Biostatistics and Epidemiology
University of Pennsylvania Perelman School of Medicine
628 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-573-5946
Fax: 215-573-4865
Education:
B.S. (Mathematics)
National Tsing-Hua University, Taiwan, 1995.
Ph.D. (Biostatistics)
Johns Hopkins University, School of Hygiene and Public Health, 2001.
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Description of Research Expertise

Biostatistics, survival data analysis, longitudinal studies, clinical trials, translational cancer research, biomarker discovery and validation, environmental health sciences, instrument development for psychosocial research

Selected Publications

Rogers AE, Hwang W-T, Scott LD, Aiken LH, Dinges DF: The working hours of hospital staff nurses and patient safety. Health Affairs 23(4): 202-212, 2004 Notes: * 2004 American Academy of Nursing Media Award.

Harris EE, Christensen VJ, Hwang W-T, Fox K, Solin LJ: Impact of concurrent versus sequential tamoxifen with radiation therapy in early-stage breast cancer patients undergoing breast conservation treatment. Journal of Clinical Oncology 23(1): 11-16, 2005.

Harris EE, Correa C, Hwang W-T, Liao J, Litt HI, Ferrari VA, Solin LJ: Late cardiac mortality and morbidity in early-stage breast cancer patients after breast conservation treatment. Journal of Clinical Oncology 24(25): 4100-4106, 2006.

Pai AL, Patino-Fernandez AM, McSherry M, Beele D, Alderfer MA, Reilly AT, Hwang W-T, Kazak AE: The psychosocial assessment tool (PAT2.0): psychometric properties of a screener for psychosocial distress in families of children newly diagnosed with cancer. Journal of Pediatric Psychology 33(1): 50-62, 2008.

Solin LJ, Orel SG, Hwang W-T, Harris EE, Schnall MD: Relationship of breast magnetic resonance imaging to outcome after breast- conservation treatment with radiation for women with early-stage invasive breast carcinoma or ductal carcinoma in situ. Journal of Clinical Oncology 26(3): 386-391, 2008.

Hwang W-T*, Adams SF*, Tahirovic E, Hagemann IS, Coukos G: Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis. Gynecologic Oncology. *Equal Contribution. 124(2): 192-198, Feb 2012 Notes: **The second most cited paper on Gynecologic Oncology since 2012 (134 citations to date).

Scholler J, Brady TL, Binder-Scholl G, Hwang W-T, Plesa G, Hege KM, Vogel AN, Kalos M, Riley JL, Deeks SG, Mitsuyasu RT, Bernstein WB, Aronson NE, Levine BL, Bushman FD, June CH: Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Science Translational Medicine 4(132): 132ra53, May 2012 Notes: *Statistical lead (248 citations to date).

Baumann BC, Guzzo TJ, He J, Keefe SM, Tucker K, Bekelman JE, Hwang W-T, Vaughn DJ, Malkowicz SB, Christodouleas JP: A novel risk stratification to predict local-regional failures in urothelial carcinoma of the bladder after radical cystectomy. International Journal of Radiation Oncology Biology Physics 85(1): 81-8, Jan 2013 Notes: *The first of a series of reports to identify who is most likely to benefit from adjuvant radiation for bladder cancer (26 citations to date).

Tebas P, Stein D, Binder-Scholl G, Mukherjee R, Brady T, Rebello T, Humeau L, Kalos M, Papasavvas E, Montaner LJ, Schullery D, Shaheen F, Brennan AL, Zheng Z, Cotte J, Slepushkin V, Veloso E, Mackley A, Hwang W-T, Aberra F, Zhan J, Boyer J, Collman RG, Bushman FD, Levine BL, June CH: Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV. Blood 121(9): 1524-33, Feb 2013 Notes: *Statistical lead in this multidisciplinary team and report (47 citations to date).

Tebas P, Stein D, Tang WW, Frank I, Wang SQ, Lee G, Spratt SK, Surosky RT, Giedlin MA, Nichol G, Holmes MC, Gregory PD, Ando DG, Kalos M, Collman RG, Binder-Scholl G, Plesa G, Hwang W-T, Levine BL, June CH: Gene editing of CCR5 in autologous CD4T cells of persons infected with HIV. New England Journal of Medicine 370(10): 901-10, Mar 2014 Notes: * Statistical lead for this first-in-man genome editing clinical trial (534 citations to date, 2015 Clinical Research Award).

Christodouleas JP, Baumann BC, He J, Hwang W-T, Tucker KN, Bekelman JE, Tangen CM, Lerner SP, Guzzo TJ, Malkowicz SB: Optimizing bladder cancer locoregional failure risk stratification after radical cystectomy using SWOG 8710. Cancer 120(8): 1272-80, Apr 2014 Notes: *Senior statistical lead (25 citations to date).

Zhong Q, Peng HL, Zhao X, Zhang L*, Hwang W-T*: Effects of BRCA1- and BRCA2-related mutations on ovarian and breast cancer survival: a meta-analysis. Clinical Cancer Research. *Corresponding authors, 21(1): 211-20, Jan 2015 Notes: The study was conducted according to PRISMA and MOOSE guidelines (33 citations to date).

Porter DL, Hwang W-T, Frey NV, Lacey SF, Shaw PA, Loren AW, Bagg A, Marcucci KT, Shen A, Gonzalez V, Ambrose D, Grupp SA, Chew A, Zheng Z, Milone M, Levine BL, Melenhorst JJ, June CH: Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia. Science Translational Medicine 7(303): 303ra139, Sep 2015 Notes: *: Second author as a statistical lead (201 citations to date).

Garfall AL*, Maus MV*, Hwang W-T, Lacey SF, Mahnke YD, Melenhorst JJ, Zheng Z, Vogl DT, Cohen AD, Weiss BM, Dengel K, Kerr ND, Bagg A, Levine BL, June CH, Stadtmauer EA: Chimeric antigen receptor T cells against CD19 for multiple myeloma. New England Journal of Medicine. *: Equal Contribution, 373(11): 1040-7, Sep 2015 Notes: ** Second author as a statistical lead (105 citations to date).

Bhoj, VG, Arhontoulis D, Wertheim G, Capobianchi J, Callahan CA, Christoph T, Ellebrecht CT, Obstfeld AE, Lacey SF, Hwang W-T, Maude SL, Wasik MA, Schuster S, Feldman MD, Porter DR, Grupp SA, June CH, Milone MC.: Persistence of long-lived plasma cells and humoral immunity in patients responding to CD19-directed CAR T cell therapy. Blood 128(3): 360-70, Jul 2016 Notes: *Statistical mentor to Dr. Bhoj.

Ojerholm E, Smith A, Hwang W-T, Baumann BC, Tucker KN, Lerner SP, Mamtani R, Boursi B, Christodouleas JP: Neutrophil-to-lymphocyte ratio as a bladder cancer biomarker: Assessing prognostic and predictive value in SWOG 8710. Cancer Oct 2016 Notes: *The study was conducted according to the Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) guidelines. DOI:10.1002/cncr.30422 [Epub ahead of print]

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Last updated: 03/07/2017
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