Surafel Mulugeta, PhD
Surafel Mulugeta, PhD
Research Assistant Professor of Medicine
Department: Medicine
Contact information
Vernon & Shirley Hill Pavilion, Suite H418
380 South University Avenue
Philadelphia, PA 19104-4539
380 South University Avenue
Philadelphia, PA 19104-4539
Office: 476-6709
Fax: 573-5985
Fax: 573-5985
Email:
mulugeta@mail.med.upenn.edu
mulugeta@mail.med.upenn.edu
Education:
BA (Biology and Chemistry)
Bluffton College, 1982.
PhD (Biomedical Sciences)
Eastern Virginia Medical School/Old Dominion University, 1997.
Permanent linkBA (Biology and Chemistry)
Bluffton College, 1982.
PhD (Biomedical Sciences)
Eastern Virginia Medical School/Old Dominion University, 1997.
Description of Research Expertise
Proficiency in the disciplines of basic research that include cell biology, biochemistry, molecular biology, neuroscience, and lung biologySelected Publications
Mulugeta, S., Beers, M.F.: Surfactant: Surfactant proteins B and C (SP-B and SP-C). Encyclopedia of Respiratory Medicine Laurent, G., Shapiro, S. (eds.). Elsevier – St. Louis, Page: 148 -151, 2006.Stevens PA., Pettenazzo A., Brasch F., Mulugeta S., Baritussio A., Ochs M., Morrison L., Russo SJ., Beers MF.: Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene. Pediatric Research 57(1): 89-98, Jan 2005.
Beers MF., Mulugeta S.: Surfactant protein C biosynthesis and its emerging role in conformational lung disease. Annual Review of Physiology 67: 663-96, 2005.
Mulugeta, S., Nguyen, V., Russo, S. J., Muniswamy, M., Beers, M. F.: A ProSP-C BRICHOS Domain Mutation Causes ER Stress, Proteasome Dysfunction, and Caspase 3 Activation Am. J. Resp. Cell Mol. Biol. 32: 521-530, May 2005.
Brasch F., Griese M., Tredano M., Johnen G., Ochs M., Rieger C., Mulugeta S., Muller KM., Bahuau M., Beers MF.: Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene.[see comment]. [Review] [46 refs] European Respiratory Journal 24(1): 30-9, Jul 2004.
Mulugeta S., Beers MF.: Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues. Journal of Biological Chemistry 278(48): 47979-86, Nov 28 2003.
Wang WJ., Mulugeta S., Russo SJ., Beers MF.: Deletion of exon 4 from human surfactant protein C results in aggresome formation and generation of a dominant negative. Journal of Cell Science 116(Pt 4): 683-92, Feb 15 2003.
Mulugeta S., Gray JM., Notarfrancesco KL., Gonzales LW., Koval M., Feinstein SI., Ballard PL., Fisher AB., Shuman H.: Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3. Journal of Biological Chemistry 277(25): 22147-55, Jun 21 2002.
Wang WJ., Russo SJ., Mulugeta S., Beers MF.: Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain. Journal of Biological Chemistry 277(22): 19929-37, May 31 2002.
Mulugeta S., Ciavarra RP., Maney RK., Tedeschi B.: Three subpopulations of fast axonally transported retinal ganglion cell proteins are differentially trafficked in the rat optic pathway. Journal of Neuroscience Research 59(2): 247-58, Jan 15 2000.