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Alice S. Chen-Plotkin, MD

Alice S. Chen-Plotkin, MD

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Assistant Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
150 Johnson Pavilion
Philadelphia, PA 19104
Office: 215-573-7193
Lab: 215-746-8191
AB (English)
Harvard-Radcliffe College, 1996.
MSc (Biology)
University of Oxford, 1998.
Harvard Medical School, 2003.
Permanent link
Perelman School of Medicine > Faculty > Search

Description of Research Expertise

The over-arching goal of our research is to better understand the mechanisms of neurodegenerative disease in order to intervene in these disease processes. Our general approach is to use unbiased genomic- or proteomic-scale screens to generate leads, which are then followed mechanistically in relevant systems. The rationale behind using genomic/proteomic-scale screens of genetic variation, mRNA expression, microRNA expression, or protein expression is that (1) they avoid bias generated by one’s preconceptions of what may be key disease genes or proteins and (2) they can give one a more global picture of pathophysiology, a picture that encompasses what is happening to an organism as a whole, or at least an organism’s genome/proteome as a whole, as these diseases progress. To conduct the type of research outlined here, we employ a combination of bench and computational methods.

We are part of the Neurology Department at the University of Pennsylvania School of Medicine. The lab is located in the Johnson Pavilion.

Description of Clinical Expertise

Movement disorders

Selected Publications

Chen-Plotkin, Alice S: Unbiased Approaches to Biomarker Discovery in Neurodegenerative Diseases. Neuron November 2014 epub.

Gallagher Michael D, Suh Eunran, Grossman Murray, Elman Lauren, McCluskey Leo, Van Swieten John C, Al-Sarraj Safa, Neumann Manuela, Gelpi Ellen, Ghetti Bernardino, Rohrer Jonathan D, Halliday Glenda, Van Broeckhoven Christine, Seilhean Danielle, Shaw Pamela J, Frosch Matthew P, Alafuzoff Irina, Antonell Anna, Bogdanovic Nenad, Brooks William, Cairns Nigel J, Cooper-Knock Johnathan, Cotman Carl, Cras Patrick, Cruts Marc, De Deyn Peter P, DeCarli Charles, Dobson-Stone Carol, Engelborghs Sebastiaan, Fox Nick, Galasko Douglas, Gearing Marla, Gijselinck Ilse, Grafman Jordan, Hartikainen Päivi, Hatanpaa Kimmo J, Highley J Robin, Hodges John, Hulette Christine, Ince Paul G, Jin Lee-Way, Kirby Janine, Kofler Julia, Kril Jillian, Kwok John B J, Levey Allan, Lieberman Andrew, Llado Albert, Martin Jean-Jacques, Masliah Eliezer, McDermott Christopher J, McKee Ann, McLean Catriona, Mead Simon, Miller Carol A, Miller Josh, Munoz David G, Murrell Jill, Paulson Henry, Piguet Olivier, Rossor Martin, Sanchez-Valle Raquel, Sano Mary, Schneider Julie, Silbert Lisa C, Spina Salvatore, van der Zee Julie, Van Langenhove Tim, Warren Jason, Wharton Stephen B, White Charles L, Woltjer Randall L, Trojanowski John Q, Lee Virginia M Y, Van Deerlin Vivianna, Chen-Plotkin Alice S: TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta neuropathologica 127(3): 407-18, Mar 2014.

Chahine Lama M, Qiang Judy, Ashbridge Emily, Minger James, Yearout Dora, Horn Stacy, Colcher Amy, Hurtig Howard I, Lee Virginia M-Y, Van Deerlin Vivianna M, Leverenz James B, Siderowf Andrew D, Trojanowski John Q, Zabetian Cyrus P, Chen-Plotkin Alice: Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations. JAMA neurology 70(7): 852-8, Jul 2013.

Qiang Judy K, Wong Yvette C, Siderowf Andrew, Hurtig Howard I, Xie Sharon X, Lee Virginia M-Y, Trojanowski John Q, Yearout Dora, Leverenz James, Montine Thomas J, Stern Matt, Mendick Susan, Jennings Danna, Zabetian Cyrus, Marek Ken, Chen-Plotkin Alice S: Plasma apolipoprotein A1 as a biomarker for parkinson's disease. Annals of neurology Feb 2013.

Alice Chen-Plotkin, Travis Unger, Michael Gallagher, Emily Bill, Linda Kwong, Laura Volpicelli-Daley, Johanna Busch, Sebastian Akle, Murray Grossman, Vivianna Van Deerlin, John Trojanowski, and Virginia Lee : TMEM106B, the risk gene for frontotemporal dementia, is regulated by the miRNA-132/212 cluster and affects progranulin pathways. Journal of Neuroscience 32(33): 11213-27, August 2012 Notes: First and corresponding author.

Chen-Plotkin Alice S, Hu William T, Siderowf Andrew, et al.: Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Annals of neurology 69(4): 655-63, Apr 2011.

Vass Ryan, Ashbridge Emily, Geser Felix, Hu William T, Grossman Murray, Clay-Falcone Dana, Elman Lauren, McCluskey Leo, Lee Virginia M Y, Van Deerlin Vivianna M, Trojanowski John Q, Chen-Plotkin Alice S: Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis. Acta neuropathologica 121(3): 373-80, Mar 2011.

Elden Andrew C*, Kim Hyung-Jun*, Hart Michael P*, Chen-Plotkin Alice S*, et al.: Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature 466(7310): 1069-75, Aug 2010 Notes: Co-first author with equal contribution.

Van Deerlin VM,* Sleiman PM,* Martinez-Lage M,* Chen-Plotkin A,* et al. : Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics 42(3): 234-9, Mar 2010 Notes: Co-first author with equal contribution.

Chen-Plotkin AS, Geser F, Plotkin JB, Clark CM, Kwong LK, Yuan W, Grossman M, Van Deerlin VM, Trojanowski JQ, Lee VM-Y: Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration. Human molecular genetics 17(10): 1349-62, May 2008.

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Last updated: 04/09/2015
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