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Barbara K Schmidt, MD, MSc

Barbara K Schmidt, MD, MSc

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Kristine Sandberg Knisely Professor in Neonatology
Department: Pediatrics
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
Division of Neonatology and Newborn Services
3400 Spruce Street, 8 Ravdin
Philadelphia, PA 19104
Office: (215) 662-3228
Fax: (215) 349-8831
Education:
MD
Georg-August University, 1976.
MD Thesis
Georg-August University, 1977.
MSc (Clinical Epidemiology and Biostatistics)
McMaster University, 1992.
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Description of Research Expertise

Barbara Schmidt, MD, MSc, is a Professor of Pediatrics and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania School of Medicine. She is also a staff neonatologist in the Division of Neonatology at the Children’s Hospital of Philadelphia and the University of Pennsylvania Health System.

Dr. Schmidt’s research focuses on collaborative neonatal randomized trials that have clinically important, long-term outcomes such as growth and development. Examples of trials she directed in the past include the “Trial of Indomethacin Prophylaxis in Preterms.” In this study, 1,202 extremely low-birth-weight infants from five countries were followed to the end of the second year of life. The results from the study showed that the high rate of mental and motor deficits in these children is not improved by prophylactic treatment with indomethacin. She is also the principal investigator of the “Caffeine for Apnea of Prematurity” trial, which enrolled over 2,000 very low-birth-weight infants in North America, Europe, Israel and Australia. Caffeine has been used for more than 30 years to regulate the breathing of very preterm babies, but without sufficient knowledge of the possible benefits and risks. To date, this trial has shown that caffeine therapy for apnea of prematurity improves the rate of survival without neurodevelopmental disability up to two years after very preterm birth. This study will continue to follow the study participants well into school age.

Since May 2010, Dr. Schmidt is a Co-Principal Investigator of the Data Coordinating Center for the Prematurity and Respiratory Outcomes Program (PROP) sponsored by NHLBI and located at the University of Pennsylvania School of Medicine. One of the goals of this multi-center collaboration is the identification of predictors of respiratory outcomes that may serve as surrogate endpoints in future trials of prevention and therapy of respiratory diseases in preterm infants. In addition, since April 2011, Dr. Schmidt is the clinical center PI for the University of Pennsylvania and Children’s Hospital of Philadelphia in the reconfigured Neonatal Research Network (NRN) of the Eunice Kennedy Shriver NICHD.

Selected Publications

Costantini L, D'llario J, Moddemann D, Penner K, Schmidt B: Accuracy of Bayley Scores as Outcome Measures in Trials of Neonatal Therapies. JAMA: Pediatrics December 2014.

Marcus CL, Meltzer LJ, Roberts RS, Traylor J, Dix J, D'ilario J, Asztalos E,Opie G, Doyle LW, Biggs SN, Nixon GM, Narang I, Bhattacharjee R, Davey M,Horne RS, Cheshire M, Gibbons J, Costantini L, Bradford R, Schmidt B: For the Caffeine for Apnea of Prematurity - Sleep (CAP-S) study. Long-term Effects of Caffeine Therapy for Apnea of Prematurity on Sleep at School-age. American Journal of Respiratory Critical Care Medicine October 2014.

Marcus CL, Traylor J, Biggs SN, Roberts RS, Nixon GM, Narang I, Bhattacharjee R, Davey MJ, Horne RS, Cheshire M, Gibbons KJ, Dix J, Asztalos E, Doyle LW, Opie GF, D'ilario J, Costantini L, Bradford R, Schmidt B: Feasibility of comprehensive, unattended ambulatory polysomnography in school-aged children. Journal of Clinical Sleep Medicine August 2014.

Doyle LW, Schmidt B, Anderson PJ, Davis PG, Moddemann D, Grunau RE, O'Brien K, Sankaran K, Herlenius E, Roberts R: Reduction in Developmental Coordination Disorder with Neonatal Caffeine Therapy. Journal of Pediatrics August 2014.

DeMauro S, Cairnie J, D'llario J, Kirpalani H, Schmidt B: Honesty, Trust and Respect during Consent Discussions in Neonatal Clinical Trials. Pediatrics July 2014.

Schmidt B, Roberts RS, Whyte RK, Asztalos EV, Poets C, Rabi Y, Solimano A, Nelson H: Impact of Study Oximeter Masking Algorithm on Titration of Oxygen Thereapy in the Canadian Oxygen Trial. Journal of Pediatrics June 2014.

Schmidt B, Davis PG, Asztalos EV, Solimano A, Roberts RS: Association between severe retinopathy of prematurity and nonvisual disabilities at age 5 years. JAMA: Journal of American Medical Association February 2014.

DeMauro SB, Cohen MS, Ratcliffe SJ, Abbasi S, Schmidt B: Serial echocardiography in very preterm infants: a pilot randomized trial. Acta Paediatrica November 2013.

Giaccone A, Jensen E, Davis P, Schmidt B: Definitions of extubation success in very premature infants: a systematic review. Arch Dis Child Fetal Neonatal Ed November 2013.

Demauro Sara B, Douglas Emily, Karp Kelley, Schmidt Barbara, Patel Jay, Kronberger Amy, Scarboro Russell, Posencheg Michael: Improving Delivery Room Management for Very Preterm Infants. Pediatrics 132(4): e1018-e1025, Oct 2013.

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Last updated: 02/18/2015
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