Barbara K Schmidt, MD, MSc
Barbara K Schmidt, MD, MSc
Kristine Sandberg Knisely Professor in Neonatology
Department: Pediatrics
Graduate Group Affiliations
Contact information
Hospital of the University of Pennsylvania
Department of Neonatology
Ravdin 8
3400 Spruce Street
Philadelphia, PA 19104
Department of Neonatology
Ravdin 8
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3228
Fax: 215-349-8831
Fax: 215-349-8831
Education:
MD (Medicine and Pediatrics)
Georg-August University, 1977.
MSc (Clinical Epidemiology and Biostatistics)
McMaster University, 1992.
Permanent linkMD (Medicine and Pediatrics)
Georg-August University, 1977.
MSc (Clinical Epidemiology and Biostatistics)
McMaster University, 1992.
Description of Research Expertise
Barbara Schmidt, MD, MSc, is a Professor of Pediatrics and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania School of Medicine. She is also a staff neonatologist in the Division of Neonatology at the Children’s Hospital of Philadelphia and the University of Pennsylvania Health System.Dr. Schmidt’s research focuses on collaborative neonatal randomized trials that have clinically important, long-term outcomes such as growth and development. Examples of trials she directed in the past include the “Trial of Indomethacin Prophylaxis in Preterms.” In this study, 1,202 extremely low-birth-weight infants from five countries were followed to the end of the second year of life. The results from the study showed that the high rate of mental and motor deficits in these children is not improved by prophylactic treatment with indomethacin. She is also the principal investigator of the “Caffeine for Apnea of Prematurity” trial, which enrolled over 2,000 very low-birth-weight infants in North America, Europe, Israel and Australia. Caffeine has been used for more than 30 years to regulate the breathing of very preterm babies, but without sufficient knowledge of the possible benefits and risks. To date, this trial has shown that caffeine therapy for apnea of prematurity improves the rate of survival without neurodevelopmental disability up to two years after very preterm birth. This study will continue to follow the study participants well into school age.
Since May 2010, Dr. Schmidt is a Co-Principal Investigator of the Data Coordinating Center for the Prematurity and Respiratory Outcomes Program (PROP) sponsored by NHLBI and located at the University of Pennsylvania School of Medicine. One of the goals of this multi-center collaboration is the identification of predictors of respiratory outcomes that may serve as surrogate endpoints in future trials of prevention and therapy of respiratory diseases in preterm infants. In addition, since April 2011, Dr. Schmidt is the clinical center PI for the University of Pennsylvania and Children’s Hospital of Philadelphia in the reconfigured Neonatal Research Network (NRN) of the Eunice Kennedy Shriver NICHD.
Selected Publications
DeMauro Sara B, Roberts Robin S, Davis Peter, Alvaro Ruben, Bairam Aida, Schmidt Barbara, : Impact of delivery room resuscitation on outcomes up to 18 months in very low birth weight infants. The Journal of pediatrics 159(4): 546-50.e1, Oct 2011.Demauro Sara B, Giaccone Annie, Kirpalani Haresh, Schmidt Barbara: Quality of Reporting of Neonatal and Infant Trials in High-Impact Journals. Pediatrics Aug 2011.
Dukhovny Dmitry, Lorch Scott A, Schmidt Barbara, Doyle Lex W, Kok Joke H, Roberts Robin S, Kamholz Karen L, Wang Na, Mao Wenyang, Zupancic John A F, : Economic evaluation of caffeine for apnea of prematurity. Pediatrics 127(1): e146-55, Jan 2011.
Davis Peter G, Schmidt Barbara, Roberts Robin S, Doyle Lex W, Asztalos Elizabeth, Haslam Ross, Sinha Sunil, Tin Win, : Caffeine for Apnea of Prematurity trial: benefits may vary in subgroups. The Journal of pediatrics 156(3): 382-7, Mar 2010.
Bassler Dirk, Stoll Barbara J, Schmidt Barbara, Asztalos Elizabeth V, Roberts Robin S, Robertson Charlene M T, Sauve Reg S, : Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: added role of neonatal infection. Pediatrics 123(1): 313-8, Jan 2009.
Kabra Nandkishor S, Schmidt Barbara, Roberts Robin S, Doyle Lex W, Papile Luann, Fanaroff Avroy, : Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms. The Journal of pediatrics 150(3): 229-34, 234.e1, Mar 2007.
Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W, for the Caffeine for Apnea of Prematurity Trial Group.: Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med 357: 1893-1902, 2007.
Schmidt Barbara, Roberts Robin S, Davis Peter, Doyle Lex W, Barrington Keith J, Ohlsson Arne, Solimano Alfonso, Tin Win, : Caffeine therapy for apnea of prematurity. The New England journal of medicine 354(20): 2112-21, May 2006.
Schmidt Barbara, Asztalos Elizabeth V, Roberts Robin S, Robertson Charlene M T, Sauve Reginald S, Whitfield Michael F, : Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms. JAMA : the journal of the American Medical Association 289(9): 1124-9, Mar 2003.
Schmidt B, Davis P, Moddemann D, Ohlsson A, Roberts R S, Saigal S, Solimano A, Vincer M, Wright L L, : Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. The New England journal of medicine 344(26): 1966-72, Jun 2001.