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Barbara K Schmidt, MD, MSc

Barbara K Schmidt, MD, MSc

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Kristine Sandberg Knisely Professor in Neonatology
Department: Pediatrics
Graduate Group Affiliations

Contact information
Hospital of the University of Pennsylvania
Division of Neonatology and Newborn Services
3400 Spruce Street, 8 Ravdin
Philadelphia, PA 19104
Office: (215) 662-3228
Fax: (215) 349-8831
Georg-August University, 1976.
MD Thesis
Georg-August University, 1977.
MSc (Clinical Epidemiology and Biostatistics)
McMaster University, 1992.
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Description of Research Expertise

Barbara Schmidt, MD, MSc, is a Professor of Pediatrics and Senior Scholar in the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania School of Medicine. She is also a staff neonatologist in the Division of Neonatology at the Children’s Hospital of Philadelphia and the University of Pennsylvania Health System.

Dr. Schmidt’s research focuses on collaborative neonatal randomized trials that have clinically important, long-term outcomes such as growth and development. Examples of trials she directed in the past include the “Trial of Indomethacin Prophylaxis in Preterms.” In this study, 1,202 extremely low-birth-weight infants from five countries were followed to the end of the second year of life. The results from the study showed that the high rate of mental and motor deficits in these children is not improved by prophylactic treatment with indomethacin. She is also the principal investigator of the “Caffeine for Apnea of Prematurity” trial, which enrolled over 2,000 very low-birth-weight infants in North America, Europe, Israel and Australia. Caffeine has been used for more than 30 years to regulate the breathing of very preterm babies, but without sufficient knowledge of the possible benefits and risks. To date, this trial has shown that caffeine therapy for apnea of prematurity improves the rate of survival without neurodevelopmental disability up to two years after very preterm birth. This study will continue to follow the study participants well into school age.

Since May 2010, Dr. Schmidt is a Co-Principal Investigator of the Data Coordinating Center for the Prematurity and Respiratory Outcomes Program (PROP) sponsored by NHLBI and located at the University of Pennsylvania School of Medicine. One of the goals of this multi-center collaboration is the identification of predictors of respiratory outcomes that may serve as surrogate endpoints in future trials of prevention and therapy of respiratory diseases in preterm infants. In addition, since April 2011, Dr. Schmidt is the clinical center PI for the University of Pennsylvania and Children’s Hospital of Philadelphia in the reconfigured Neonatal Research Network (NRN) of the Eunice Kennedy Shriver NICHD.

Selected Publications

Schmidt B, Davis PG, Asztalos EV, Solimano A, Roberts RS: Association between severe retinopathy of prematurity and nonvisual disabilities at age 5 years. JAMA: Journal of American Medical Association February 2014.

DeMauro SB, Cohen MS, Ratcliffe SJ, Abbasi S, Schmidt B: Serial echocardiography in very preterm infants: a pilot randomized trial. Acta Paediatrica November 2013.

Giaccone A, Jensen E, Davis P, Schmidt B: Definitions of extubation success in very premature infants: a systematic review. Arch Dis Child Fetal Neonatal Ed November 2013.

Demauro Sara B, Douglas Emily, Karp Kelley, Schmidt Barbara, Patel Jay, Kronberger Amy, Scarboro Russell, Posencheg Michael: Improving Delivery Room Management for Very Preterm Infants. Pediatrics 132(4): e1018-e1025, Oct 2013.

Sherenian Michael, Profit Jochen, Schmidt Barbara, Suh Sanghee, Xiao Rui, Zupancic John A F, Demauro Sara B: Nurse-to-Patient Ratios and Neonatal Outcomes: A Brief Systematic Review. Neonatology 104(3): 179-183, August 2013.

Schmidt Barbara, Whyte Robin K, Asztalos Elizabeth V, Moddemann Diane, Poets Christian, Rabi Yacov, Solimano Alfonso, Roberts Robin S: Effects of targeting higher vs lower arterial oxygen saturations on death or disability in extremely preterm infants: a randomized clinical trial. JAMA: the journal of the American Medical Association 309(20): 2111-20, May 2013.

Guillén Ursula, DeMauro Sara, Ma Li, Zupancic John, Roberts Robin, Schmidt Barbara, Kirpalani Haresh: Relationship between attrition and neurodevelopmental impairment rates in extremely preterm infants at 18 to 24 months: a systematic review. Archives of pediatrics & adolescent medicine 166(2): 178-84, Feb 2012.

Doyle Lex W, Davis Peter G, Schmidt Barbara, Anderson Peter J: Cognitive outcome at 24 months is more predictive than at 18 months for IQ at 8-9 years in extremely low birth weight children. Early human development 88(2): 95-8, Feb 2012.

Schmidt Barbara, Anderson Peter J, Doyle Lex W, Dewey Deborah, Grunau Ruth E, Asztalos Elizabeth V, Davis Peter G, Tin Win, Moddemann Diane, Solimano Alfonso, Ohlsson Arne, Barrington Keith J, Roberts Robin S: Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity. JAMA: the journal of the American Medical Association 307(3): 275-82, Jan 2012.

DeMauro Sara B, Roberts Robin S, Davis Peter, Alvaro Ruben, Bairam Aida, Schmidt Barbara, : Impact of delivery room resuscitation on outcomes up to 18 months in very low birth weight infants. The Journal of pediatrics 159(4): 546-50.e1, Oct 2011.

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Last updated: 04/22/2014
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