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Mariarita Santi, M.D., Ph.D.

Mariarita Santi, M.D., Ph.D.

faculty photo
Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine

Contact information
The Children's Hospital of Philadelphia
324 South 34th Street
Room 5NW26
Philadelphia, PA 19104
Office: 215-590-3184
Fax: 215- 590-1736
Education:
B.S.
Classic Lyceum Reggio Emilia, Italy, 1974.
M.D.
Modena University Medical School, Modena, Italy, 1982.
Ph.D. (Pharmacology)
Modena University , 1988.
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Description of Clinical Expertise

Pediatric and Adult Brain Tumors, Pediatric and Adult Muscle Disease, Tumor Banks

Selected Publications

Majzner R, Simon JS, Gross JF, Martinez D, Pawel B, Santi M, Merchant M, Geoerger B, Hezam I, Marty V, Vielh P, Daugaard M, Sorensen P, Mackall C and Maris J.: Assessment of PD-L1 expression and tumor associated immune cells in pediatric cancer tissue. Cancer Accepted , March 2017.

Xu T1, Zhang H1, Park SS1, Venneti S1, Kuick R2, Ha K1, Michael LE3, Santi M4, Uchida C5, Uchida T6, Srinivasan A7, Olson JM8, Dlugosz AA3, Camelo-Piragua S9, Rual JF10: Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis. Neoplasia 19(3): 216-225, February 2017.

Bayliss J1, Mukherjee P2, Lu C3, Jain SU4, Chung C1, Martinez D5, Sabari B3, Margol AS6, Panwalkar P1, Parolia A1,7, Pekmezci M8, McEachin RC9, Cieslik M1,7, Tamrazi B10, Garcia BA11, La Rocca G12, Santi M5, Lewis PW4, Hawkins C13,14, Melnick A2, David Allis C3, Thompson CB12, Chinnaiyan AM1,7, Judkins AR15, Venneti S16.: Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas. Sci Transl Med. 8(366): 366ra161, November 2016.

Barth PG1,2, Aronica E2, Fox S3, Fluiter K4, Weterman MA4, Poretti A5, Miller DC6, Boltshauser E7, Harding B8, Santi M8, Baas F4.: Deregulated expression of EZH2 in congenital brainstem disconnection. Neuropathol Appl Neurobiol In press, November 2016.

Ramaswamy V, Hielscher T, Mack S, Lassaletta A, Lin T, Pajtler K, Jones DTW, Luu B, Cavalli FMG, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon R, Lipp ES, Dunham C, Hukin J, Eisenstat D, Fulton D, Van Landeghem F, Santi M, Van Veelen-Vincent M-L, Van Meir E, Osuka S, Fan X, Muraszko K, Tirapelli D, Oba-Shinjo S, Marie S, Carlotti C, Lee JY, Rao AN, Giannini C, Faria C, Nunes S, Mora J, Hamilton R, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognar I, Klekner A, Hortobàgyi T, Leary S, Ermoian R, Olson J, Leonard J, Gardner C, Grajkowska W, Chambless L, Cain J, Eberhart C, Adsan S, Massimino M, Giangaspero F, Buttarelli F, Packer RJ, Emery L, Yong W, Soto H, Liau L, Everson R, Grossbach A, Shalaby T, Groszer M, Karajannis M, Zagzag D, Wheeler H, Von Hoff K, Alonso M, Tuñon T, Schűller U, Zitterbart K, Sterba J, Chan J, Guzman M, Elbabaa S, Colman H, Dhall G, Fisher P, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro A, Pollack I, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins C, Rutka J, Dirks P, Pfister S, Merchant T, Gilbert M, Armstrong TS, Korshunov A, Ellison D, and Taylor MD: Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis. Journal of Clinical Oncology. doi: 10.1200/jco.2015.65.7825, 34(21), July 2016.

Roth JJ, Fierst TM, Waander A, Yimei L, Biegel JA, Santi M: Whole chromosome 7 gain predicts higher risk of recurrence in pediatric pilocytic astrocytomas independently from KIAA1549-BRAF fusion status. Journal of Neuropathology and Experimental Neurology 75(4): 306-315, April 2016 Notes: doi: 10.1093/jnen/nlw001.

Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L, O'Rourke R, Gibson, WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE, Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Varlet P, Pages M, Horowitz PM, Federation A, Malkin H, Tracy A, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C, Puget S, Hawkins C, Tabori U, Klekner LB, Bognar L, Burger PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S, Haas-Kogan DA, Phillips J, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Grill J, Ligon AH, Gourmerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC: MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism. Nature Genetics 48(3): 273-282, March 2016 Notes: doi: 10.1038/ng.3500.

Sturm D, Orr AB, Umut H, Toprak UH, Volker H, Jones DTW, Capper D, Sill M, Buchhalter I, Northcott PA, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen SJ, Balasubramanian G, Worst B, Pajtler KW, Brabetz S, Johann PD, Sahm F, Reimand J, Mackay A, Carvalho DM, Remke M, Phillips JJ, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Lastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley BC, Schniederjan MJ, Santi M, Buccoliero AM, Dahiya S, Kramm CM, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald MC, Milde T, Hasselblatt M, Wesseling P,Röbler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins P, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann MU, Shalaby T, Grotzer M, van Meter T, Monoranu CM, Felsberg J, Reifenberger G, Snuderl M, Forrester LA, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore AS, Taylor MD, Jones C, Jabado N, Karajannis MA, Eils R, Schlesner M, Licter P, von Deimling A, Pfister SM, Ellison DW, Korshunov A, Kool M: New Brain tumour entities emerge from molecular classification of CNS-PNETs. Cell 164(5): 1060-1072, February 2016 Notes: doi: 10.1016/j.cell.2016.01.015.

Ng JM, Martinez D, Marsh ED, Zhang Z, Rappaport E, Santi M and Curran T.: Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53. Cancer Res 75(21): 4629-39, Nov 2015 Notes: doi: 10.1158/0008-5472.CAN-15-0874.

Skjei KL, Church EW, Harding BN, Santi M, Holland-Bouley KD, Clancy RR, Porter BE, Heuer GG, Marsh ED: Clinical and histopathological outcomes in patients with SCN1A mutations undergoing surgery for epilepsy. J Neurosurg Pediatr 4: 1-7, Sept 2015.

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Last updated: 03/31/2017
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