Mariarita Santi, M.D., Ph.D.

faculty photo
Professor of Pathology and Laboratory Medicine at the Children's Hospital of Philadelphia
Department: Pathology and Laboratory Medicine

Contact information
The Children's Hospital of Philadelphia
324 South 34th Street
Room 5NW26
Philadelphia, PA 19104
Office: 215-590-3184
Fax: 215- 590-1736
Education:
B.S.
Classic Lyceum Reggio Emilia, Italy, 1974.
M.D.
Modena University Medical School, Modena, Italy, 1982.
Ph.D. (Pharmacology)
Modena University , 1988.
Permanent link
 
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Description of Clinical Expertise

Pediatric and Adult Brain Tumors, Pediatric and Adult Muscle Disease, Tumor Banks

Selected Publications

Panwalkar Pooja, Clark Jonathan, Ramaswamy Vijay, Hawes Debra, Yang Fusheng, Dunham Christopher, Yip Stephen, Hukin Juliette, Sun Yilun, Schipper Matthew J, Chavez Lukas, Margol Ashley, Pekmezci Melike, Chung Chan, Banda Adam, Bayliss Jill M, Curry Sarah J, Santi Mariarita, Rodriguez Fausto J, Snuderl Matija, Karajannis Matthias A, Saratsis Amanda M, Horbinski Craig M, Carret Anne-Sophie, Wilson Beverly, Johnston Donna, Lafay-Cousin Lucie, Zelcer Shayna, Eisenstat David, Silva Marianna, Scheinemann Katrin, Jabado Nada, McNeely P Daniel, Kool Marcel, Pfister Stefan M, Taylor Michael D, Hawkins Cynthia, Korshunov Andrey, Judkins Alexander R, Venneti Sriram: Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome. Acta neuropathologica 134(5): 705-714, Nov 2017.

Abath Neto O, Moreno CAM, Malfatti E, Donkervoort S, Böhm J, Guimarães JB, Foley AR, Mohassel P, Dastgir J, Bharucha-Goebel DX, Monges S, Lubieniecki F, Collins J, Medne L, Santi M, Yum S, Banwell B, Salort-Campana E, Rendu J, Fauré J, Yis U, Eymard B, Cheraud C, Schneider R, Thompson J, Lornage X, Mesrob L, Lechner D, Boland A, Deleuze JF, Reed UC, Oliveira ASB, Biancalana V, Romero NB, Bönnemann CG, Laporte J, Zanoteli E.: Common and variable clinical, histological, and imaging findings of recessive RYR1-related centronuclear myopathy patients. Neuromuscul Disord. 27(11): 975-985, Nov 2017.

Majzner Robbie G, Simon Jason S, Grosso Joseph F, Martinez Daniel, Pawel Bruce R, Santi Mariarita, Merchant Melinda S, Geoerger Birgit, Hezam Imene, Marty Virginie, Vielh Phillippe, Daugaard Mads, Sorensen Poul H, Mackall Crystal L, Maris John M: Assessment of programmed death-ligand 1 expression and tumor-associated immune cells in pediatric cancer tissues. Cancer 123(19): 3807-3815, Oct 2017.

Bosse Kristopher R, Raman Pichai, Zhu Zhongyu, Lane Maria, Martinez Daniel, Heitzeneder Sabine, Rathi Komal S, Kendsersky Nathan M, Randall Michael, Donovan Laura, Morrissy Sorana, Sussman Robyn T, Zhelev Doncho V, Feng Yang, Wang Yanping, Hwang Jennifer, Lopez Gonzalo, Harenza Jo Lynne, Wei Jun S, Pawel Bruce, Bhatti Tricia, Santi Mariarita, Ganguly Arupa, Khan Javed, Marra Marco A, Taylor Michael D, Dimitrov Dimiter S, Mackall Crystal L, Maris John M: Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. Cancer cell 32(3): 295-309.e12, Sep 2017.

Majzner R, Simon JS, Gross JF, Martinez D, Pawel B, Santi M, Merchant M, Geoerger B, Hezam I, Marty V, Vielh P, Daugaard M, Sorensen P, Mackall C and Maris J.: Assessment of PD-L1 expression and tumor associated immune cells in pediatric cancer tissue. Cancer Epub ahead of print , June 2017.

Xu T, Zhang H, Park SS, Venneti S, Kuick R, Ha K, Michael LE, Santi M, Uchida C, Uchida T, Srinivasan A, Olson JM, Dlugosz AA, Camelo-Piragua S, Rual JF: Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis. Neoplasia 19(3): 216-225, February 2017.

Bayliss J, Mukherjee P, Lu C, Jain SU, Chung C, Martinez D, Sabari B, Margol AS, Panwalkar P, Parolia A, Pekmezci M, McEachin RC, Cieslik M, Tamrazi B, Garcia BA, La Rocca G, Santi M, Lewis PW, Hawkins C, Melnick A, David Allis C, Thompson CB, Chinnaiyan AM, Judkins AR, Venneti S.: Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas. Sci Transl Med. 8(366): 366ra161, November 2016.

Barth PG1,2, Aronica E2, Fox S3, Fluiter K4, Weterman MA4, Poretti A5, Miller DC6, Boltshauser E7, Harding B8, Santi M8, Baas F4.: Deregulated expression of EZH2 in congenital brainstem disconnection. Neuropathol Appl Neurobiol In press, November 2016.

Ramaswamy V, Hielscher T, Mack S, Lassaletta A, Lin T, Pajtler K, Jones DTW, Luu B, Cavalli FMG, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon R, Lipp ES, Dunham C, Hukin J, Eisenstat D, Fulton D, Van Landeghem F, Santi M, Van Veelen-Vincent M-L, Van Meir E, Osuka S, Fan X, Muraszko K, Tirapelli D, Oba-Shinjo S, Marie S, Carlotti C, Lee JY, Rao AN, Giannini C, Faria C, Nunes S, Mora J, Hamilton R, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognar I, Klekner A, Hortobàgyi T, Leary S, Ermoian R, Olson J, Leonard J, Gardner C, Grajkowska W, Chambless L, Cain J, Eberhart C, Adsan S, Massimino M, Giangaspero F, Buttarelli F, Packer RJ, Emery L, Yong W, Soto H, Liau L, Everson R, Grossbach A, Shalaby T, Groszer M, Karajannis M, Zagzag D, Wheeler H, Von Hoff K, Alonso M, Tuñon T, Schűller U, Zitterbart K, Sterba J, Chan J, Guzman M, Elbabaa S, Colman H, Dhall G, Fisher P, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro A, Pollack I, Prados M, Robins HI, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins C, Rutka J, Dirks P, Pfister S, Merchant T, Gilbert M, Armstrong TS, Korshunov A, Ellison D, and Taylor MD: Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis. Journal of Clinical Oncology. doi: 10.1200/jco.2015.65.7825, 34(21), July 2016.

Roth JJ, Fierst TM, Waander A, Yimei L, Biegel JA, Santi M: Whole chromosome 7 gain predicts higher risk of recurrence in pediatric pilocytic astrocytomas independently from KIAA1549-BRAF fusion status. Journal of Neuropathology and Experimental Neurology 75(4): 306-315, April 2016 Notes: doi: 10.1093/jnen/nlw001.

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Last updated: 11/09/2017
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