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George M. Shaw, M.D., Ph.D.

George M. Shaw, M.D., Ph.D.

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Perelman School of Medicine
University of Pennsylvania
409 Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-8514
Fax: 215-573-8976
Education:
B.A.
Dartmouth College, 1975.
Ph.D. (Pharmacology)
The Ohio State University, 1979.
M.D.
The Ohio State University, 1980.
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Description of Research Expertise

My laboratory has a longstanding interest in human and simian immunodeficiency virus (HIV/SIV) molecular biology and pathogenesis and hepatitis C virus (HCV). Previous highlights of this work include the first molecular clones of HIV-1 (Shaw et al., Science 1984); recognition of the quasispecies nature of HIV-1 in vivo (Saag et al., Nature 1988); discovery of the dynamic and persistent nature of viral replication in vivo (Clark et al., N Engl J Med 1991; Piatak et al., Science 1993; Wei et al., Nature 1995); mechanisms of virus persistence in the face of evolving cellular and humoral immune responses (Borrow et al., Nature Medicine 1997; Wei et al., Nature 2003); and molecular identification and biological characterization of transmitted HIV-1 genomes and their progeny (Keele et al., Proc Natl Acad Sci USA 2008; Salazar et al., J Exp Med 2009; Li et al., PLoS Pathogens 2010). More recently, we have extended the work to SIV infection of rhesus macaque monkeys (Keele et al., J Exp Med 2009) and HCV infection of humans (Li et al., CROI 2011).

Current projects in the laboratory include:

1. Molecular studies of HIV-1 transmission, persistence and pathogenesis. This project area includes a molecular and biological analysis of HIV-1 viruses responsible for transmission and productive clinical infection resulting from heterosexual, homosexual and intravenous exposures and their subsequent evolution. The long-range goal is to develop effective vaccine strategies to prevent infection.

2. Molecular studies of SIV transmission, persistence and pathogenesis. This project area aims to develop more relevant SIV-rhesus macaque mucosal infection models and a clearer understanding of viral-host events responsible for transmission and productive clinical infection. A practical application of this work is in HIV/SIV vaccine design and assessment.

3. Molecular studies of HCV transmission, persistence and pathogenesis. This project area aims to leverage our recent discoveries in HIV-1 and SIV transmission biology based on single genome amplification and sequencing of plasma virion RNA to elucidate HCV transmission and early virus evolution. A major goal of this work will be to gain insights into immunopathogenic mechanisms of virus containment and persistence relevant to therapeutics and vaccine design. A second major goal is the development of novel strategies for identifying and characterizing full-length infectious molecular clones of HCV representing the seven major pandemic genotypes for use in in vitro and in vivo modeling and analyses.

Members of the Shaw Lab

Current members of the Shaw lab, with the month and the year they joined the lab, and a brief description of their projects (updated summer 2011):

Research Assistant Professors:
Fred Bibollet-Ruche, Ph.D.
(07/98) Molecular evolution and pathogenesis of SIV.
Hui Li, M.D. (07/03) HIV, SIV and hepatitis C virus transmission biology and pathogenesis.

Research Associate:
Shuyi Wang, M.D.
(06/01) Single genome amplification and sequencing of HIV/SIV/HCV.

Post-doctoral Research Fellow:
Ranjit Warrier, Ph.D.
(07/10) Molecular analysis of SIV transmission and vaccine prevention.

Graduate Students:
Rui Kong
(05/07) Neutralization of HIV-2 in vitro and in vivo.
Joshua Baalwa, M.D. (08/07) Molecular pathogenesis of HIV-1 clade A, C and D viruses.
Michael Lopker (09/09) Molecular pathogenesis of transmitted/founder SIVsmE660 and SIVmac251 viruses.
Mark Stoddard (09/10) Molecular identification and pathogenesis of transmitted/founder hepatitis C viruses.

Lab Manager:
Erica Parrish
(10/10) HIV/SIV biology; BSL 2+ tissue culture core facility.

Selected Publications

281. Liu W, Y Li, KS Shaw, GH Learn, L Plenderleith, JA Malenke, SA Sundararaman, MA Ramirez, PA Crystal, AG Smith, F Bibollet-Ruche, A Ayouba, S Locatelli, A Esteban, F Mouacha, E Guichet, C Butel, S Ahuka-Mundeke, B-I Inogwabini, J-BN Ndjango, S Speede, CM Sanz, DB Morgan, MK Gonder, PJ Kranzusch, PD Walsh, AV Georgiev, MN Muller, AK Piel, FA Stewart, ML Wilson, AE Pusey, L Cui, Z Wang, A Färnert, CJ Sutherland, D Nolder, JA Hart, TB Hart, P Bertolani, A Gillis, M LeBreton, B Tafon, J Kiyang, CF Djoko, BS Schneider, ND Wolfe, E Mpoudi-Ngole, E Delaporte, R Carter, RL Culleton, GM Shaw, JC Rayner, M Peeters, BH Hahn and PM Sharp: African origin of the malaria parasite Plasmodium vivax. Nat Commun 5: 3346, Feb 2014.

Fenton-May AE, O Dibben, T Emmerich, H Ding, K Pfafferott, MM Aasa-Chapman, P Pellegrino, I Williams, MS Cohen, F Gao, GM Shaw, BH Hahn, C Ochsenbauer, JC Kappes, and P Borrow: Relative resistance of HIV-1 founder viruses to control by interferon-alpha. Retrovirology 10: 146, Dec 2013.

Li H, L Blair, Y Chen, G Learn, K Pfafferott, M John, T Bhattacharya, BH Hahn, S Mallal, GM Shaw, and KJ Bar: Molecular mechanisms of HIV type 1 prophylaxis failure revealed by single-genome sequencing. J Infect Dis 208(10): 1598-603, Sep 2013.

Klein K, RS Veazey, R Warrier, P Hraber, LA Doyle-Meyers, V Buffa, HX Liao, BF Haynes, GM Shaw, and RJ Shattock: Neutralizing IgG at the portal of infection mediates protection against vaginal SHIV challenge. J Virol Aug 2013.

Permar SR, MG Salazar, F Gao, F Cai, GH Learn, L Kalilani, BH Hahn, GM Shaw and JF Salaraz-Gonzalez: Clonal amplification and maternal-infant transmission of nevirapine-resistant HIV-1 variants in breast milk following single-dose nevirapine prophylaxis. Retrovirology 10: 88, Aug 2013.

Ping L-H, SB Joseph, JA Anderson, M-R Abrahams, JF Salazar-Gonzalez, LP Kincer, FK Treurnicht, L Arney, S Ojeda, M Zhang, J Keys, EL Potter, H Chu, P Moore, M Salazar-Gonzalez, S Iyer, C Jabara, J Kirchherr, C Mapanje, N Ngandu, C Seoighe, I Hoffman, F Gao, Y Tang, C Labranche, B Lee, A Saville, M Vermeulen, S Fiscus, L Morris, S Abdool Karim, BF Haynes, GM Shaw, BT Korber, BH Hahn, MS Cohen, D Montefiori, C Williamson, R Swanstrom, and for the CAPRISA Acute Infection Study the Center for HIV-AIDS Vaccine Immunology Consortium: Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design. J Virol 87(13): 7218-33, Jul 2013.

Lopker M, J Easlick, S Sterrett, JM Decker, H Barbian, G Learn, BF Keele, JE Robinson, H Li, BH Hahn, GM Shaw, and KJ Bar: Heterogeneity in neutralization sensitivities of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock. J Virol 87(10): 5477-92, May 2013.

Liao HX, R Lynch, T Zhou, F Gao, SM Alam, SD Boyd, AZ Fire, KM Roskin, CA Schramm, Z Zhang, J Zhu, L Shapiro; NISC Comparative Sequencing Program, JC Mullikin, S Gnanakaran, P Hraber, K Wiehe, G Kelsoe, G Yang, SM Xia, DC Montefiori, R Parks, KE Lloyd, RM Scearce, KA Soderberg, M Cohen, G Kamanga, MK Louder, LM Tran, Y Chen, F Cai, S Chen, S Moquin, X Du, MG Joyce, S Srivatsan, B Zhang, A Zheng, GM Shaw, BH Hahn, TB Kepler, BT Korber, PD Kwong, JR Mascola, BF Haynes: Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 496(7446): 469-76, Apr 2013.

Parrish NF, F Gao, H Li, EE Giorgi, HJ Barbian, EH Parrish, L Zajic, SS Iyer, JM Decker, A Kumar, B Hora, A Berg, F Cai, J Hopper, TN Denny, H Ding, C Ochsenbauer, JC Kappes, RP Galimidi, AP West Jr., PJ Bjorkman, CB Wilen, RW Doms, M O’Brien, N Bhardwaj, P Borrow, BF Haynes, M Muldoon, JP Theiler, B Korber, GM Shaw, and BH Hahn: Phenotypic properties of transmitted founder HIV-1. Proc Natl Acad Sci U S A 110(17): 6626-33, Apr 2013.

Sundararaman SA, W Liu, BF Keele, GH Learn, K Bittinger, F Mouacha, S Ahuka-Mundeke, M Manske, S Sherrill-Mix, Y Li, JA Malenke, E Delaporte, C Laurent, E Mpoudi Ngole, DP Kwiatkowski, GM Shaw, JC Rayner, M Peeters, PM Sharp, FD Bushman, and BH Hahn: Plasmodium falciparum-like parasites infecting wild apes in southern Cameroon do not represent a recurrent source of human malaria. Proc Natl Acad Sci U S A 110(17): 7020-5, Apr 2013.

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Last updated: 07/21/2014
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