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Delia Maria Talos, MD

Delia Maria Talos, MD

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Research Assistant Professor of Neurology
Department: Neurology

Contact information
University of Pennsylvania
Perelman School of Medicine
263 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-8328
Fax: 215-662-3362
Education:
MD (Medicine)
University of Cologne, Germany, 1992.
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Description of Research Expertise

There is increasing evidence from animal models that activation of innate and adaptive immunity may contribute to the development of epilepsy. In addition, studies of surgical tissue removed from patients with uncontrolled seizures demonstrate persistent inflammation despite treatment with conventional antiepileptic drugs, suggesting that this process may be a target for novel therapies. Our laboratory is investigating the potential role of cytokines and chemokines in modulating neuronal excitability. Specifically, we have found that several pro-inflammatory cytokines are highly upregulated in both rodent and human epileptic brain. Interestingly, we have also found that the expression of these cytokines at baseline vary with age. Certain cytokines peak during adolescence, while others demonstrate elevated levels with advancing age, suggesting specific age windows of vulnerability that may predispose to brain inflammation. Currently, we are assessing the acute and chronic effects of these cytokines on neuronal function in vitro in order to begin to elucidate their mechanisms of action. In parallel, our laboratory uses several epilepsy mouse models to test the efficacy of new therapies that suppress inflammation to improve both the occurrence of seizures and the development of chronic epilepsy.

Selected Publications

Sun H, Talos DM, Jensen FE: Impairment of homeostatic synaptic scaling in epileptic immature brain. Society for Neuroscience Meeting, San Diego, CA Neuroscience Meeting Planner. Program No. 406.02 / J3 2016 Notes: Poster.

K Yu, D Kuzum, S-W Hwang, B Kim, H Juul, N Kim, S Won, K Chiang, M Trumpis, A Richardson, H Cheng, H Fang, M Thompson, H Bink, D Talos, K J Seo, H Lee, S-K Kang, J H Kim, J Lee, Y Huang, F Jensen, M Dichter, T Lucas, J Viventi, B Litt, and J Rogers. : Bioresorbable Silicon Electronics for Transient Spatio-temporal Mapping of Electrical Activity from the Cerebral Cortex. Nat Mater. 15(7): 782-91, 2016.

Butler T, Li Y, Tsui W, Friedman D, Maoz A, Wang X, Harvey P, Tanzi E, Morim S, Kang Y, Mosconi L, Talos D, Kuzniecky R, Vallhabjosula S, Thesen T, Glodzik L, Ichise M, Silbersweig D, Stern E, de Leon MJ, French J: Transient and chronic seizure-induced inflammation in human focal epilepsy. Epilepsia 57(9): 191-4, 2016.

Salah A, Devinsky O, Talos DM, Tsien RW: Increased spontaneous activity and seizure susceptibility in a mouse model of Timothy Syndrome Society for Neuroscience Meeting, San Diego, CA Neuroscience Meeting Planner. Program No. 680.26 / F6 2016 Notes: Poster.

Jacobs L, Choudhury K, Sun H, Talos DM : Early Astrocyte-Mediated Inflammatory Responses in a Mouse Model of Tuberous Sclerosis. American Epilepsy Society Annual Meeting, Houston, TX, Abstract Viewer: 3.025 2016 Notes: Poster.

Jacobs LM, Coto CA, Juul H, Dichter MA, Jensen FE, Talos DM: Increased brain expression of tau and hyperphosphorylated tau in human therapy-resistant epilepsy Society for Neuroscience Meeting, San Diego, CA Neuroscience Meeting Planner. Program No. 691.02 / M9 2016 Notes: Poster.

Jantzie LL, Talos DM, Jackson MC, Park HK, Graham DA, Lechpammer M, Folkerth RD, Volpe JJ, Jensen FE: Developmental Expression of N-Methyl-D-Aspartate (NMDA) Receptor Subunits in Human White and Gray Matter: Potential Mechanism of Increased Vulnerability in the Immature Brain. Cereb Cortex 25(2): 482-95, 2015.

Coto CA, Jacobs LM, Balu R, Lucas T, Martinez-Lage M, Davis K, Talos DM, Jensen FE. : Evidence for altered glutamate homeostasis in human temporal lobe epilepsy. American Epilepsy Society Annual Meeting, Philadelphia, PA, Abstract Viewer: 3.076 2015 Notes: Poster.

Jacobs LM, Coto CA, Sun H, Lucas T, Martinez-Lage M, Davis K, Jensen FE, Talos DM: Overactivation of mTOR signaling pathway in human therapy-resistant temporal lobe epilepsy. American Epilepsy Society Annual Meeting, Philadelphia, PA, Abstract Viewer: 3.070 2015 Notes: Poster.

Ruppe V, Dilsiz P, Reiss CS, Carlson C, Devinsky O, Zagzag D, Weiner HL, Talos DM: Developmental brain abnormalities in tuberous sclerosis complex: A comparative tissue analysis of cortical tubers and perituberal cortex. Epilepsia 55(4): 539-50, 2014.

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Last updated: 06/19/2017
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