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Delia Maria Talos,

Delia Maria Talos

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Research Assistant Professor of Neurology
Department: Neurology

Contact information
University of Pennsylvania
Perelman School of Medicine
263 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104
Office: 215-573-8328
Fax: 215-662-3362
Education:
MD (Medicine)
University of Cologne, Germany, 1992.
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Description of Research Expertise

There is increasing evidence from animal models that activation of innate and adaptive immunity may contribute to the development of epilepsy. In addition, studies of surgical tissue removed from patients with uncontrolled seizures demonstrate persistent inflammation despite treatment with conventional antiepileptic drugs, suggesting that this process may be a target for novel therapies. Our laboratory is investigating the potential role of cytokines and chemokines in modulating neuronal excitability. Specifically, we have found that several pro-inflammatory cytokines are highly upregulated in both rodent and human epileptic brain. Interestingly, we have also found that the expression of these cytokines at baseline vary with age. Certain cytokines peak during adolescence, while others demonstrate elevated levels with advancing age, suggesting specific age windows of vulnerability that may predispose to brain inflammation. Currently, we are assessing the acute and chronic effects of these cytokines on neuronal function in vitro in order to begin to elucidate their mechanisms of action. In parallel, our laboratory uses several epilepsy mouse models to test the efficacy of new therapies that suppress inflammation to improve both the occurrence of seizures and the development of chronic epilepsy.

Selected Publications

Jantzie LL, Talos DM, Jackson MC, Park HK, Graham DA, Lechpammer M, Folkerth RD, Volpe JJ, Jensen FE: Developmental Expression of N-Methyl-D-Aspartate (NMDA) Receptor Subunits in Human White and Gray Matter: Potential Mechanism of Increased Vulnerability in the Immature Brain. Cereb Cortex 25(2): 482-95, 2015.

Ruppe V, Dilsiz P, Reiss CS, Carlson C, Devinsky O, Zagzag D, Weiner HL, Talos DM: Developmental brain abnormalities in tuberous sclerosis complex: A comparative tissue analysis of cortical tubers and perituberal cortex. Epilepsia 55(4): 539-50, 2014.

Talos, DM, Ruppe, V, Dilsiz, P, Coley A, Gill, AJ, Kolson, DL, Jensen, FE, Sun, H: Elevated neuroinflammatory responses in a mouse model of Tuberous Sclerosis Complex (TSC) American Academy of Neurology, Philadelphia, PA 2014 Notes: Poster.

Coley AA, Sun H, Soldan SS, Jensen FE, Talos DM: Increased neuroinflammation in a mouse model of Tuberous sclerosis. American Epilepsy Society Annual Meeting, Seattle, WA, Abstract Viewer: 3.041 2014 Notes: Poster.

Sun, H, Talos DM, Goto, J, Juul H, Coley, A, Kwiatkowski, DJ, Jensen, FE : Bumetanide attenuates neuronal network hyperexcitability and improves survival in a mouse model of tuberous sclerosis. American Academy of Neurology, Philadelphia, PA 2014 Notes: Poster.

Di Nardo A, Wertz MH, Kwiatkowski E, Tsai PT, Leech JD, Greene-Colozzi E, Goto J, Dilsiz P, Talos DM, Clish CB, Kwiatkowski DJ, Sahin M: Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Hum Mol Genet 23(14): 3865-74, 2014.

Loddenkemper T, Talos DM, Cleary RT, Joseph A, Sánchez Fernández I, Alexopoulos A, Kotagal P, Najm I, Jensen FE: Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus. Epilepsy Res 108(4): 605-15, 2014.

Butler T, Zaborszky L, Pirraglia E, Li J, Wang XH, Li Y, Tsui W, Talos DM, Devinsky O, Kuchna I, Nowicki K, French J, Kuzniecky R, Wegiel J, Glodzik L, Rusinek H, Deleon MJ, Thesen T: Comparison of human septal nuclei MRI measurements using automated segmentation and a new manual protocol based on histology Neuroimage 97: 245-51, 2014.

Cleary R, Huynh T, Manning SM, Sun H, Li Y, Rotenberg A, Talos DM, Jackson MC, Rakhade SN, Berry G Jensen FE: Synergistic Anticonvulsant Efficacy of Combination Treatment by Phenobarbital and NKCCI Inhibitor Bumetanide in a Rat Model of Neonatal Seizures. PLoS One 8(3): e57148, 2013.

Talos DM, Chang M, Kosaras B, Fitzgerald BC, Murphy A, Folkerth RD, Jensen FE: Anti-epileptic Effects of Levetiracetam in a Rodent Neonatal Seizure Model. Pediatr Res 73(1): 24-30, 2013.

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Last updated: 04/13/2015
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