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Delia Maria Talos,

Delia Maria Talos

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Research Assistant Professor of Neurology
Department: Neurology

Contact information
New York University
Langone Medical Center
100 Washington Square East
Brown Building, Room 753
New York, NY 10003
Education:
MD (Medicine)
University of Cologne, Germany, 1992.
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Description of Research Expertise

There is increasing evidence from animal models that activation of innate and adaptive immunity may contribute to the development of epilepsy. In addition, studies of surgical tissue removed from patients with uncontrolled seizures demonstrate persistent inflammation despite treatment with conventional antiepileptic drugs, suggesting that this process may be a target for novel therapies. Our laboratory is investigating the potential role of cytokines and chemokines in modulating neuronal excitability. Specifically, we have found that several pro-inflammatory cytokines are highly upregulated in both rodent and human epileptic brain. Interestingly, we have also found that the expression of these cytokines at baseline vary with age. Certain cytokines peak during adolescence, while others demonstrate elevated levels with advancing age, suggesting specific age windows of vulnerability that may predispose to brain inflammation. Currently, we are assessing the acute and chronic effects of these cytokines on neuronal function in vitro in order to begin to elucidate their mechanisms of action. In parallel, our laboratory uses several epilepsy mouse models to test the efficacy of new therapies that suppress inflammation to improve both the occurrence of seizures and the development of chronic epilepsy.

Selected Publications

Cleary R, Huynh T, Manning SM, Sun H, Li Y, Rotenberg A, Talos DM, Jackson MC, Rakhade SN, Berry G Jensen FE: Synergistic Anticonvulsant Efficacy of Combination Treatment by Phenobarbital and NKCCI Inhibitor Bumetanide in a Rat Model of Neonatal Seizures. PLoS One 8(3): e57148, 2013.

Talos DM, Chang M, Kosaras B, Fitzgerald BC, Murphy A, Folkerth RD, Jensen FE: Anti-epileptic Effects of Levetiracetam in a Rodent Neonatal Seizure Model. Pediatr Res 73(1): 24-30, 2013.

Butler T, Zaborszky L, Talos DM, Dilsiz P, Wang X, McDonald CR, Blackmon K, DuBois J, Carlson C, Burr WB, French J, Kuzniecky R, Halgren E, Devinsky O, Thesen T: MRI and Immunohistochemical Evidence of Septo-Hippocampal Cholinergic System Augmentation in Human Temporal Lobe Epilepsy. American Epilepsy Society Meeting, San Diego, CA, Abstract Viewer 2.031 2012 Notes: Poster.

Dilsiz P, Ruppe V, Weiner H, Shoshkes Reiss C, Najjar S, French J, Devinsky O, Talos DM: Evidence of Increased Neuroinflammation in Human Tuberous Sclerosis Complex: Potential Implications for Neurological Dysfunction. American Epilepsy Society Meeting, San Diego, CA, Abstract Viewer 3.046 2012 Notes: Poster.

Talos DM, Sun H, Kosaras B, Joseph A, Folkerth RD, Poduri A, Madsen JR, Black PM, Jensen FE: Altered Inhibition in Tuberous Sclerosis and Type IIb Cortical Dysplasia. Ann Neurol 71 (4): 539-551, 2012.

Ruppe V, Dilsiz P, Carlson C, Shoshkes Reiss C, Zagzag D, Devinsky O, Weiner H, Talos DM: Developmental Abnormalities in Epileptogenic Tuberous Sclerosis Complex Lesions: A Comparison Analysis of Cortical Tubers and Peri-Tuberal Brain. American Epilepsy Society Meeting, San Diego, CA, Abstract Viewer 1.036 2012 Notes: Poster.

Salah A, Dilsiz P, Frecska-Horvath, Ruppe V, Shoshkes Reiss C, Carlson C, Doyle W, Devinsky O, Talos DM: Altered NMDA and AMPA Receptor Subunit Expression in Cortical Tissue From Autism and Treatment-Resistant Temporal Lobe Epilepsy. American Epilepsy Society Meeting, San Diego, CA, Abstract Viewer 3.052 2012 Notes: Poster.

Talos DM, Sun H, Zhou X, Fitzgerald BC, Jackson MC, Klein PM, Lan VI, Joseph A, Jensen FE: The Interaction Between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTORCI) Pathway. PLoS One 7(5): e35885, 2012.

Dilsiz P, Mikolaenko I, Carlson C, Doyle W, Devinsky O, Talos DM: Comparison Analysis of Glutamate Receptor Subunit Expression in Cortical Tissue From Autism Versus Treatment-Resistant Chronic Epilepsy Patients. Society for Neuroscience Meeting, New Orleans, LA Neuroscience Meeting Planner. Program No. 160.04/M4 2012 Notes: Poster.

Ruppe V, Dilsiz P, Weiner H, Shoshkes Reiss C, French J, Devinsky O, Talos DM: Potential Role of Neuroinflammation in the Epileptogenicity of uman Tuberous Sclerosis Complex Cortical Lesions. Society for Neuroscience Meeting, Washington DC Neuroscience Meeting Planner. Program No. 458.10/Y6 2011 Notes: Poster.

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Last updated: 05/14/2014
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