Jonathan W. Tanner, M.D., Ph.D.
Jonathan W. Tanner, M.D., Ph.D.
Assistant Professor of Clinical Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Contact information
Dulles Building, Room 777
3400 Spruce Street
Philadelphia, PA 19104
3400 Spruce Street
Philadelphia, PA 19104
Office: 215 662 7053
Fax: 215 615 3898
Fax: 215 615 3898
Email:
tannerj@uphs.upenn.edu
tannerj@uphs.upenn.edu
Education:
B.A. (Mathematics)
Harvard University, Summa Cum Laude, 1985.
M.D.-Ph.D. (Physiology)
University of Pennsylvania, 1992.
Permanent linkB.A. (Mathematics)
Harvard University, Summa Cum Laude, 1985.
M.D.-Ph.D. (Physiology)
University of Pennsylvania, 1992.
Description of Research Expertise
depth of sedation monitoring, sedation for gastrointestinal endoscopy, mechanism of inhalational anesthetic agents, calorimetryDescription of Clinical Expertise
anesthesia for procedures outside the operating rooms (gastrointestinal endoscopy, radiology, electrophysiology, and electroconvulsive procedures) and for orthopedic, gynecologic, and/or ambulatory surgerySelected Publications
Jonathan W. Tanner: Using isothermal titration calorimetry for thermodynamic parameter determination of weak binding: chloroform to serum albumin. Biophysical Journal 86: 359a-360a, 2004.Jonathan W. Tanner: Weak binding thermodynamic parameter determination using isothermal titration calorimetry: a general method. Presented at the Current Trends in Microcalorimetry Conference, Boston / published in proceedings on www.microcalorimetry.com 2003.
Tanner, J.W., Valentine, K.G. Valentine, Lucchese, A.M., Meng, Q.C., A. Joshua Wand: "Isoflurane does not induce major structural changes in the pore-lining segment of a ligand-gated ion channel" Anesthesiology 96: A98, 2002.
Eckenhoff, R.G., Tanner, J.W., Liebman, P.A.: Cooperative binding of inhaled anesthetics and ATP to firefly luciferase. Proteins: Structure, Function and Genetics 42: 436-441, 2001.
Tanner, J.W., Johansson, J.S., Liebman, P.A., Eckenhoff, R.G.: Predictability of weak binding from x-ray crystallography: inhaled anesthetics and myoglobin. Biochemistry 40: 5075-5080, 2001.
Tanner, Jonathan W.: Destabilization of proteins by millimolar halothane correlates with their heat capacity change for unfolding. Presented at the Biocalorimetry Conference, Philadelphia / published in proceedings on www.microcalorimetry.com 2001.
Johansson, J.S., Tanner, J.W: Perturbation of lipid and protein structure by general anesthetics: How little is too little? Letter (In Reply). Anesthesiology 92: 1492-1494, 2000.
Eckenhoff, R.G., Tanner, J.W., Liebman, P.A.: Mechanism of anesthetic-induced destabilization of soluble proteins. Progress in Anesthetic Mechanism 6: 154-164, 2000.
Tanner, J.W.: Mechanism of inhalational anesthetics. Current Anesthesiology Reports 2: 347-352, 2000.
Eckenhoff, R.G., Tanner, J.W., Liebman, P.A.: Firefly luciferase is stabilized by anesthetics only in the presence of ATP. Biophysical Journal 78: 296A, 2000.