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Toshinori Hoshi, PhD

Toshinori Hoshi, PhD

faculty photo
Professor of Physiology
Department: Physiology
Graduate Group Affiliations

Contact information
605 CRB
415 Curie Blvd
Department of Physiology
Philadelphia, PA 19104
Office: 215-573-7305
Education:
B.A. (Psychology)
University of New Hampshire, 1981.
Ph.D. (Physiology)
Yale University, 1985.
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Description of Research Expertise

RESEARCH INTERESTS
Ion channel modulation such as calcium-dependent potassium channels by heme, heme breakdown products such as CO, and lipid messengers including PIP2 and omega-3 fatty acids

KEY WORDS:
neuronal excitability, ion channel gating, oxidation, methionine, aging, blood, heme, CO, brain hemorrhage, lipids, PIP2, omega-3 fatty acids, fish oil, BK channel, Slo1, KCNMA1, KCNMB, KCa1.1, LRRC, potassium channels, voltage sensor, Shaker channels, EAG, Kv, KCNH

RESEARCH TECHNIQUES
Electrophysiology (patch clamp, voltage-clamp, extracellular recording, optical recording); molecular biology; tissue culture; vascular smooth muscle physiology; physiology and behavior.

RESEARCH SUMMARY
We study modulation of ion channels such as large-conductance calcium- and voltage-gated potassium channels and EAG channels by different signaling molecules. The modulators/modulatory processes being examined include: oxidation/reduction of amino acids, carbon monoxide, heme, bilirubin oxidation end products, PIP2 and omega-3 fatty acids.

Selected Publications

Hoshi, T., Wissuwa, B., Tian, Y., Tajima, N., Xu, R., Bauer, M., Heinemann, S. H., Hou, S: Omega-3 Fatty Acids Lower Blood Pressure by Directly Activating Large-Conductance Ca2+-Dependent K+ Channels. Proc Natl Acad Sci U S A 110: 4816-4821, 2013.

Hoshi, T., Xu, R., Hou, S., Heinemann, S. H., Tian, Y: A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. J Gen Physiol 142: 507-522, 2013.

Hoshi, T., Tian, Y., Xu, R., Heinemann, S. H., Hou, S: Mechanism of the Modulation of BK Potassium Channel Complexes with Different Auxiliary Subunit Compositions by the Omega-3 Fatty Acid DHA. Proc Natl Acad Sci U S A 110: 4822-1877, 2013.

Hoshi T, Pantazis A, Olcese R.: Transduction of voltage and Ca2+ signals by Slo1 BK channels. Physiology (Bethesda) 28: 172-189, 2013.

Hoshi T, Armstrong CM.: C-type inactivation of voltage-gated K+ channels: pore constriction or dilation? J Gen Physiol. 141: 151-160, 2013.

Sahoo, N., Goradia, N., Ohlenschlager, O., Schonherr, R., Friedrich, M., Plass, W., Kappl, R., Hoshi, T., Heinemann, S. H.: Heme impairs the ball-and-chain inactivation of potassium channels. Proc Natl Acad Sci U S A 110: E4036-4044, 2013.

Sahoo, N., Hoshi, T., Heinemann, S. H: Oxidative modulation of voltage-gated potassium channels. Antioxidants & redox signaling 2013/09/18 2013.

Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA, Jr. : Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. Am J Respir Cell Mol Biol. 46: 132-138, 2012.

Damera G, Druey KM, Cooper PR, Krymskaya VP, Soberman RJ, Amrani Y, Hoshi T, Brightling CE, Panettieri RA, Jr.: An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma. PLoS One 7: e28504, 2012.

Hoshi T, Armstrong CM. : Initial steps in the opening of a Shaker potassium channel. Proc Natl Acad Sci U S A. 109, 2012.

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Last updated: 03/07/2014
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