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Ethan M. Goldberg, M.D., Ph.D.

Assistant Professor of Neurology
Instructor A of Neurology, The Perelman School of Medicine at The University of Pennsylvania
Department: Neurology

Contact information
The Children's Hospital of Philadelphia
Division of Neurology
Abramson Research Center, Room 502A
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6894
Fax: 215-590-1771
Lab: 215-590-5671
Graduate Group Affiliations
Education:
B.A. (Neurobiology)
Harvard University, 1999.
Ph.D. (Physiology & Neuroscience)
New York University School of Medicine, 2006.
M.D.
New York University School of Medicine, 2008.
Post-Graduate Training
Intern in Pediatrics, The Children's Hospital of Philadelphia, 2008-2009.
Resident in Pediatrics, The Children's Hospital of Philadelphia, 2009-2010.
Resident, Adult and Child Neurology, The Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia, 2010-2013.
Post-doctoral Epilepsy Research, Douglas A. Coulter, PhD Laboratory, The Children's Hospital of Philadelphia, 2013-2015.
Certifications
American Board of Psychiatry and Neurology (ABPN), 2013.
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Description of Clinical Expertise

Pediatric Neurology; Neurology; Epilepsy; Neurogenetics; Epiepsy Neurogenetics; Developmental Delay and Autism.

Description of Research Expertise

Epilepsy; Neurobiology of Disease; Physiology; Ion channels; Two-photon imaging.

Selected Publications

Zaman, T., Helbig, I., Božović, I.B., DeBrosse, S.D., Bergqvist, A.C., Wallis, K., Medne, L., Maver, A., Peterlin, B., Helbig, K.L., Zhang, X., Goldberg, E.M.: Mutations in SCN3A cause early infantile epileptic encephalopathy. Annals of Neurology 83(4): 703-717, February 2018.

Tran, C.H., Vaiana, M., Goldstein, N., Muldoon, S.F., and Goldberg, E.M.: In vivo two-photon calcium imaging shows cell type-specific activity during seizure propagation in a model of Dravet syndrome (1.014). Poster presentation at the American Epilepsy Society Annual Meeting, Washington, D.C. December 2017.

Vaiana, M., Goldberg, E.M., and Muldoon, S.F.: Real-time, automatic calcium image segmentation via topology (721.15). Poster presentation at the Society for Neuroscience Annual Meeting, Washington, D.C. November 2017.

Favero, M., Casey, C., and Goldberg, E.M.: Developmental trajectory of interneuron dysfunction in a mouse model of Dravet syndrome (560.15). Poster presentation at the Society for Neuroscience Annual Meeting, Washington, D.C. November 2017.

Platzer, K., Hongjie, Y., Schütz, H., Winschel, A., Chen, W., Hu, C., Kusumoto, H., Heyne, H.O., Helbig, K.L., Tang, S., Willing, M.C., Tinkle, B.T., Adams, D.J., Depienne, C., Keren, B., Mignot, C., Frengen, E., Strømme, P., Biskup, S., Döcker, D., Strom, T.M., Mefford, H.C., Myers, C.T., Muir, A.M., LaCroix A., Sadleir, L., Scheffer, I.E., Brilstra, E., van Haelst, M.M., van der Smagt, J.J., Bok Levinus, A., Møller, R.,S., Jensen, U.B., Millichap, J.J., Berg, A.T., Goldberg, E.M., De Bie, I., Fox, S., Major, P., Jones, J.R., Zackai, E.H., Abou, J.R., Rolfs, A., Leventer, R.J., Lawson, J.A., Roscioli, T., Jansen, F.E., Ranza, E., Korff, C.M., Lehesjoki, A.E., Courage, C., Linnankivi, T., Smith, D.R., Stanley, C., Mintz, M., McKnight, D., Decker, A., Tan, W.-H., Tarnopolsky, M.A., Brady , L.I., Wolff, M., Dondit, L., Pedro, H.F., Parisotto, S.E., Jones, K.L., Patel, A.D., Anup D., Franz, D.N., Vanzo, R., Marco, E., Ranells, J.D., Di Donato, N., Dobyns, W.B., Laube, B., Traynelis, S.F., Lemke, J.R.: GRIN2B encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects. Journal of medical genetics 54(7): 460-470, July 2017.

Shen, D., Hernandez, C.C., Shen, W., Hu, N., Poduri, A., Shiedley, B., Rotenberg, A., Datta, A.N., Leiz, S., Patzer, S., Boor, R., Ramsey, K., Goldberg, E., Helbig, I., Ortiz-Gonzalez, X.R., Lemke, J.R., Marsh, E.D., Macdonald, R.L.: De novo GABRG2 mutations associated with epileptic encephalopathies. Brain 140: 49-67, January 2017.

Goldberg, E.M.: "Simultaneous twophoton calcium imaging and optogenetics using GCaMP6 and ChrimsonR" (92.28) Poster presentation at the Society for Neuroscience Annual Meeting in San Diego, CA. November 2016.

Tian, G., Cristancho, A.G., Dubbs, H.A., Liu, G.T,. Cowan, N.J., Goldberg, E.M.: A patient with lissencephaly, developmental delay, and infantile spasms, due to de novo heterozygous mutation of KIF2A. Molecular Genetics & Genomic Medicine 4(6): 599-603, November 2016.

de Kovel, C.G.F., Syrbe, S., Brilstra, E.H., Verbeek, N., Kerr, B., Dubbs, H., Bayat, A., Desai, S., Naidu, S., Srivastava, S., Cagaylan, H., Yis, U., Saunders, C., Rook, M., Plugge, S., Muhle, H., Afawi, Z., Klein, K.M., Jayaraman, V., Rajagopalan, R., Goldberg, E., Marsh, E., Kessler, S., Bergqvist, C., Conlin, L.K., Krok, B.L., Thiffault, I., Pendziwiat, M., Helbig, I., Polster, T., Borggraefe, I., Lemke, J.R., van den Boogaardt, M.J., Møller, R.S., Koeleman, B.P.C.: Neurodevelopmental Disorders Caused by De Novo Variants in KCNB1 Genotypes and Phenotypes. JAMA Neurology 74(10): 1228, October 2016.

Natan, R.G., Briguglio, J.J., Mwilambwe-Tshilobo, L., Jones, S., Aizenberg, M., Goldberg, E.M., Geffen, M.N.: Complementary control of sensory adaptation by two types of cortical interneurons. eLife 4: e09868, November 2015.

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Last updated: 05/01/2018
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