Perelman School of Medicine at the University of Pennsylvania
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Sydney M. Evans

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Sydney M. Evans VMD, MS

Professor of Radiation Oncology
Department: Radiation Oncology

Contact information
187 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-898-0074
Education:
BS (Pre-Veterinary Medicine)
Rutgers University, Douglas College, 1973.
VMD (Veterinary Medicine)
University of Pennsylvania, School of Veterinary Medicine , 1977.
MS (Comparative Medical Sciences)
University of Pennsylvania, School of Veterinary Medicine , 1986.
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Description of Research Expertise

KEYWORDS:
Measuring hypoxia in vivo; Animal Models of human disease; Cancer physiology, proliferation; Cancer physiology; tumor vasculature

RESEARCH INTERESTS:
The primary emphasis of the work in the Evans laboratory is to determine causes of treatment resistance in human cancer. The treatment resistance factor that is emphasized is hypoxia. The presence, level and distribution of hypoxia is measured using a 2-nitroimidazole agent, EF5, developed by Dr. Cameron Koch, also from the Department of Radiation Oncology, at PENN. EF5 can be used for in vitro or in vivo studies. The majority of studies in the Evans laboratory involve in vivo studies in animals or humans. Given intravenously, this agent is reduced and bound in hypoxic cells. The adducts thus formed are recognized by a specific fluorescent monoclonal antibody. Tumor tissue or cells are studied either using immunohistochemistry or flow cytometry. This fluorescence can be measured and converted into tissue pO2 based upon previously published in vitro studies. We have performed studies using EF5 in animal models of cancer and, since 1998 have been performing clinical trials to evaluate the presence and level of hypoxia in various human cancers. We are currently funded by the NIH to perform studies in human brain tumors, head and neck cancers, sarcomas, cervix, and intraperitoneal cancers. We have shown that hypoxia, as measured by EF5 binding correlates to the level of tumor aggression in glial brain tumors, soft tissue sarcomas and head/neck squamous cell cancers. We have recently been able to produce [F-18]-EF5, which can be analyzed with positron emission tomography, PET imaging. Grants to study EF5 binding, with both immunohistochemical and PET endpoints in patients with brain tumors and head and neck cancer have been funded by the NIH.

Description of Clinical Expertise

Measuring hypoxia and predicting treatment response in brain tumors
Measuring hypoxia and predicting treatment responsein cervix cancer
Measuring hypoxia and predicting treatment responsein head and neck squamous cell carcinoma
Measuring hypoxia and predicting treatment responsein carcinomatosis and sarcomatosis
Measuring hypoxia and predicting treatment responsein pleural cancers
Measuring hypoxia and predicting treatment response in soft tissue sarcomas

Description of Other Expertise

Mentoring junior faculty
Mentoring women

Selected Publications

Koch CJ, Evans SM: Optimizing Hypoxia Detection and Treatment Strategies. Semin Nucl Med 45(2): 163-76, Mar 2015.

Koch CJ, Lustig RA, Yang XY, Jenkins WT, Wolf RL, Martinez-Lage M, Desai A, Williams D, Evans SM: Microvesicles as a Biomarker for Tumor Progression versus Treatment Effect in Radiation/Temozolomide-Treated Glioblastoma Patients. Transl Oncol 7(6): 752-8, Dec 2014.

Koch CJ, Jenkins WT, Jenkins KW, Yang XY, Shuman AL, Pickup S, Riehl1 CR, Paudya R, Poptani H, Evans SM: Mechanisms of Blood Flow and Hypoxia Production in Rat 9L Epigastric Tumors. Tumor Microenvironment and Therapy 1(1): 1-13, Jan 2013.

Sood, N Jenkins, WT Yang, X-Y Shah, NN Katz, JS Koch, CJ Frail, PR Therein, MJ Hammer, DA Evans, SM: Biodegradable polymersomes for the delivery of Gemcitabine to Panc-1 cells. Journal of Pharmaceutics (on line). Hindawi Publishing Company, 2013(932797), 2013.

Lilie L Lin, LL Antti Silvoniemi James B Stubbs Ramesh Rengan Sami Suilamo Olof Solin Chaitanya Divgi Olli Eskola Jonathan M. Sorger Michael G. Stabin Alexander Kachur Stephen M. Hahn Tove Grönroos Sarita Forsback Sydney M Evans Cameron J. Koch Heikki Minn: Radiation Dosimetry and Biodistribution of the Hypoxia Tracer 18F-EF5 in Oncologic Patients. Cancer Biotherapy & Radiopharmaceuticals 27(7): 412-9, Sep 2012.

Marotta D, Karar J, Jenkins WT, Kumanova M, Tobias JW, Baldwin D, Hadjigeorgiou A, Alexiou P, Evans SM, Alarcon R, Maity A, Koch CJ, Koumenis C: In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer Research (eds.). 71(3): 779-89, Feb 2011

Evans SM, Jenkins KW, Chen HI, Jenkins WT, Judy KD, Hwang W-T, Lustig RA, Judkins AR, Grady MS, Hahn SM, Koch CJ: The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study. Translational Oncology 3(3): 160–9, Jun 1 2010

Koch CJ, Scheuermann JS, Divgi C, Judy KD, Kachur A, Freifelder R, Saffer J, Karp J, Stubbs JM, Hahn SM, Driesbaugh J, Smith D, Prendergast S, Evans SM: Biodistribution and dosimetry of 18F-EF5 in cancer patients with preliminary comparison of 18F-EF5 uptake versus EF5 binding in human glioblastoma. European Journal of Nuclear medicine and Molecular Imaging 37(11): 2048-59, Nov 2010.

Koch CJ, Shuman AL, Jenkins WT, Kachur AV, Karp JS, Freifelder R, Dolbier WR, Evans SM: The radiation response of cells from 9L gliosarcoma tumors is correlated with [F18]-EF5 uptake. International Journal of Radiation Biology 85(12): 1137-47, Dec 2009

Cerniglia G, Pore N, Tsai JH, Schultz S, Mick R, Regine C, Xiaoman X, Durduran T, Yodh AG, Evans SM, Koch CJ, Hahn SM, Quon H, Sehgal CM, Lee W M-F, Maity A: Epidermal growth factor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy. PloS one 4(8): e6539, Aug 2009.

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Last updated: 05/13/2015
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