Perelman School of Medicine at the University of Pennsylvania
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Keith A. Cengel

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Keith A. Cengel, MD, PhD

Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Smilow Center for Translational Research, Room 8-136
Univ of Pennsylvania, Perelman School of Medicine
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
Office: 215-898-1035
Fax: 215-349-5445
Lab: 215-898-0838
Education:
BS (Biochemistry)
University of Illinois at Urbana-Champaign, 1991.
BS (Biology)
University of Illinois at Urbana-Champaign, 1991.
MS (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1993.
PhD (Cellular/Molecular Biology)
University of Illinois at Urbana-Champaign, 1998.
MD (Medical)
University of Illinois at Urbana-Champaign, 2001.
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Description of Research Expertise

1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.

2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.

3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.

Description of Clinical Expertise

Photodynamic Therapy
Radiation therapy for neuroendocrine and thoracic tumors

Selected Publications

Sanzari JK, Wan XS, Wroe AJ, Rightnar S, Cengel KA, Diffenderfer ES, Krigsfeld GS, Gridley DS, Kennedy AR: Acute Hematological Effects of Solar Particle Event Proton Radiation in the Porcine Model. Radiat Res. 180(1): 7-16, Jul 2013.

Whaley JT, Kirk M, Cengel K, McDonough J, Bekelman J, Christodouleas JP: Protective Effect of Transparent Film Dressing on Proton Therapy Induced Skin Reactions. Radiat Oncol. 8: 19, Jan 24 2013.

Cengel KA, Sanzari J, Billings P, Diffenderfer ES, Kennedy AR: Evaluating Radiation Repose And Countermeasures For Exposure To Solar Particle Events With Differing Energy-Fluence Profiles. Heavy Ion in Therapy and Space Radiation Symposium 2013, Chiba, Japan 2013.

Cengel KA, Sanzari J, Billings P, Diffenderfer ES, Kennedy AR: Determining The Whole Body Radiation Repose To Solar Particle Events With Differing Energy-fluence Profiles. NASA Human Research Program Investigator's Workshop, Galveston, TX 2013.

Cengel KA, Kennedy AR: NSBRI Center For Acute Radiation Research: Dosimetric and Practical Considerations for Simulating Solar Particle Event Exposure for Earth Based Model Systems. National Space Biomedical Research Institute Radiation Effects Team 2013.

Chandra A, Lan S, Zhu J, Lin T, Zhang X, Siclari VA, Altman AR, Cengel KA, Liu XS, Qin L.: PTH prevents the adverse effects of focal radiation on bone architecture in young rats. Bone. 55(2): 449-57, Aug 2013.

Pietrofesa R, Turowski J, Tyagi S, Dukes F, Arguiri E, Busch TM, Gallagher-Colombo SM, Solomides CC, Cengel KA, Christofidou-Solomidou M: Radiation mitigating properties of the lignan component in flaxseed. BMC Cancer. 13: 179, Apr 4 2013.

Edmonds C, Hagan S, Gallagher-Colombo SM, Busch TM, Cengel KA: Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer. Cancer Biol Ther. 13(14): 1463-70, Dec 1 2012.

Cengel K, Yendamuri S, Demmy T, Culligan M, Schofield M, Smith D, Punekar S, Sterman D, Stevenson J, Busch T, Glatstein E, Hahn S, Friedberg J : Qualitative And Quantitative Differences in the Toxicity Of HPPH-Mediated PDT with a 24 Versus 48-Hour Drug Light Interval: Moving from the Bedside to the Bench and Back. SPIE Photonics West, San Francisco, CA 2012.

Machtay M, Scherpereel A, Santiago J, Lee J, McDonough J, Kinniry P, Arguiri E, Shuvaev VV, Sun J, Cengel K, Solomides CC, Christofidou-Solomidou M: Systemic polyethylene glycol-modified (PEGylated) superoxide dismutase and catalase mixture attenuates radiation pulmonary fibrosis in the C57/bl6 mouse. Radiother Oncol. 81(2): 196-205, Nov 2006.

Lee JC, Krochak R, Blouin A, Kanterakis S, Chatterjee S, Arguiri E, Vachani A, Solomides CC, Cengel KA, Christofidou-Solomidou M: Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury. Cancer Biol Ther. 8(1): 43-9, Jan 2008.

Hill-Kayser CE, Avery S, Mesina CF, James P, Friedberg JS, Cengel K, Lin LL, Hahn SM, Rengan R: Hemithoracic radiotherapy after extrapleural pneumonectomy for malignant pleural mesothelioma: a dosimetric comparison of two well-described techniques. J Thorac Oncol. 4(11): 1431-7, Nov 2009.

Lee JC, Kinniry PA, Arguiri E, Serota M, Kanterakis S, Chatterjee S, Solomides CC, Javvadi P, Koumenis C, Cengel KA, Christofidou-Solomidou M: Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res. 173(5): 590-601, May 2010.

Wilson JM, Sanzari JK, Diffenderfer ES, Yee SS, Seykora JT, Maks C, Ware JH, Litt HI, Reetz JA, McDonough J, Weissman D, Kennedy AR, Cengel KA: Acute Biological Effects of Simulating the Whole Body Radiation Dose Distribution from a Solar Particle Event Using a Porcine Model. Radiat Res. 176(5): 649-59, Nov 2011.

Christofidou-Solomidou M, Tyagi S, Tan KS, Hagan S, Pietrofesa R, Dukes F, Arguiri E, Heitjan DF, Solomides CC, Cengel KA: Dietary flaxseed administered post-thoracic radiation treatment improves survival and mitigates radiation-induced Pneumonopathy in mice. BMC Cancer. 11: 269, Jun 24 2011.

York JM, Blevins NA, Meling DD, Peterlin MB, Gridley DS, Cengel KA, Freund GG: The Biobehavioral and Neuroimmune Impact of Low-Dose Ionizing Radiation. Brain Behav Immun. 26(2): 218-27, Feb 2012.

Fishbein L, Bonner L, Torigian DA, Nathanson KL, Cohen DL, Pryma D, Cengel KA: External Beam Radiation Therapy (EBRT) for Patients with Malignant Pheochromocytoma and Non-Head and Neck Paraganglioma: Combination with 131I-MIBG. Horm Metab Res. 44(5): 405-10, May 2012.

Allen AM, Pawlicki T, Dong L, Fourkal E, Buyyounouski M, Cengel K, Plastaras J, Bucci MK, Yock TI, Bonilla L, Price R, Harris EE, Konski AA: An Evidence Based Review of Proton Beam Therapy: The Report of ASTRO's Emerging Technology Committee. Radiother Oncol. 103(1): 8-11, Apr 2012.

Christofidou-Solomidou M, Tyagi S, Pietrofesa R, Dukes F, Arguiri E, Turowski J, Grieshaber PA, Solomides CC, Cengel KA: Radioprotective Role In Lung Of The Flaxseed Lignan Complex Enriched In The Phenolic Secoisolaricresinol Diglucoside (SDG). Radiat Res. 178(6): 568-80, Dec 2012.

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Last updated: 06/13/2014
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