Department of Radiation Oncology

Andrea Facciabene

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Andrea Facciabene, Ph.D.

Research Assistant Professor of Radiation Oncology
Department: Radiation Oncology

Contact information
University of Pennsylvania Perelman School of Medicine
Department of Radiation Oncology
Smilow Center for Translational Research Rm. 8-133
3400 Civic Center Blvd., Bldg 421
Philadelphia, PA 19104
Office: 215-746-7071
Fax: 215-898-0090
BS (Pharmaceutical Biotechnology Science (summa cum laude))
University of Bologna, Italy (Thesis: Centre of Drug Discovery, L'Aquila, Italy) Summa Cum Laude, 2000.
PhD (Cancer Rsrch & Molecular Biol & Biotechnology)
Univ of Perugia in collaboration with the Univ of California San Diego, San Diego, CA (coursework 11/01-5/05 in Italy; exam in CA 2/06), 2006.
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Description of Research Expertise

Dr. Andrea Facciabene’s laboratory is focussed on immunotherapy and investigation of the network of immune responses to tumors, combining basic research and clinical investigation. Our goals are to advance understanding of tumor immunology and to use new findings to develop efficacious new therapies. Our basic research includes the development of two new vaccination strategies: one uses mitochondria isolated from tumors, the other utilizes new tumor vasculature antigen. We also study regulation of immune surveillance and the tumor microenvironment by the gut microbiome. Our clinic research includes the development of new preclinical immunotherapies.

Selected Publications

Janos Tanyi, Mark Morgan, Andrea Facciabene: book chapter: Impact of gut microbiota on Ovarian Cancer Springer. Erle Robertson (eds.). Mar 2018.

Uribe-Herranz M, Bittinger K, Rafail S, Guedan S, Pierini S, Tanes C, Ganetsky A, Morgan MA, Gill S, Tanyi JL, Bushman FD, June CH, Facciabene A.: Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12. JCI Insight. 3(4), Feb 2018.

De Sanctis F, Ugel S, Facciponte J, Facciabene A: The dark side of tumor-associated endothelial cells. Semin Immunol. Feb 2018.

Lei J, Xie L, Zhao H, Gard C, Clemens JL, McLane MW, Feller MC, Ozen M, Novak C1, Alshehri W1, Alhejaily N, Shabi Y, Rosenzweig JM, Facciabene A, Burd I.: Maternal CD8+ T-cell depletion alleviates intrauterine inflammation-induced perinatal brain injury. Am J Reprod Immunol. 10, Dec 2017.

Pierini S, Perales-Linares R, Uribe-Herranz M, Pol JG, Zitvogel L, Kroemer G, Facciabene A, Galluzzi L.: Trial watch: DNA-based vaccines for oncological indications. Oncoimmunology 6(12), Nov 2017.

Stefano Pierini, Renzo Perales-Linares, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvogel, Guido Kroemer, Andrea Facciabene & Lorenzo Galluzzi ... show less Stefano Pierini, Renzo LOinares-Parales, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvoge, Guido Kormer, Andrea Facciabene and Lorenzo Galluzzi. : Trial Watch: DNA-based vaccines for oncological indications. Oncoimmunology Oct 2017 Notes: Co-Corresponding and Co-Last author.

Lei J, Rosenzweig JM, Mishra MK, Alshehri W, Brancusi F, McLane M, Almalki A, Bahabry R, Arif H, Rozzah R, Alyousif G, Shabi Y, Alhehaily N, Zhong W1 Facciabene A, Kannan S, Kannan RM, Burd I.: Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury. Scientific Report 7: 1-12, Jul 2017.

Facciabene A, De Sanctis F, Pierini S, Reis E, Balint K, Router J, Facciponte J, De Angelis R, Magotti P, Lambris J, Coukos G.: Local Endothelial Complement Activation Reverses Endothelial Quiescence, Enabling T-cell Homing and Tumor Control during T-cell Immunotherapy. Oncoimmunology 6(9), Jun 2017.

Facciabene A, De Sanctis F, Pierini S, Reis ES, Balint K, Facciponte J, Rueter J, Kagabu M, Magotti P, Lanitis E, DeAngelis RA, Buckanovich RJ, Song WC, Lambris JD, Coukos G.: Local endothelial complement activation reverses endothelial quiescence, enabling t-cell homing, and tumor control during t-cell immunotherapy. Oncoimmunology 6(9), Jun 2017.

Monk BJ, Facciabene A,(Equal Contribution) Brady WE, Aghajanian C, Fracasso PM, Walker J, Lankes HA, Manjarrez KL, Danet-Desnoyers G, Bell-McGuinn KM, McCourt CK, Malykhin A, Hershberg RM, Coukos G. *Contributed Equally : Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemo-immunotherapy. Clin Cancer Res. AACR, 23(8): 1955-1966, Apr 2017.

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Last updated: 03/15/2018
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